Compile Data Set for Download or QSAR
Report error Found 507 of affinity data for UniProtKB/TrEMBL: P00811
TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50274047(CHEMBL3613796)
Affinity DataKi:  0.0500nMAssay Description:Inhibition of Escherichia coli AmpC using CENTA as substrate by spectrometry based Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM466971(2-fluoro-2-(((2S,5R)-3-methyl-7-oxo-2-((pyrazin-2-...)
Affinity DataIC50: 1.80nMAssay Description:A buffer consisting of 0.1 M sodium phosphate (pH 7.0), 10 mM NaHCO3, and 0.005% Triton X-100 was used for all enzymes. The chromogenic substrate nit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM466985((2S)-2-fluoro-2-[[(2S,5R)-3-methyl-7-oxo-2-(pyrazi...)
Affinity DataIC50: 2nMAssay Description:A buffer consisting of 0.1 M sodium phosphate (pH 7.0), 10 mM NaHCO3, and 0.005% Triton X-100 was used for all enzymes. The chromogenic substrate nit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50149467((5R,6Z)-6-(6,7-dihydro-5H-cyclopenta-[d]imidazo[2,...)
Affinity DataIC50: 2nMAssay Description:In vitro inhibitory activity against Class C (Amp-C) beta-LactamasesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50149466(Sodium; (R)-6-[1-(5,6-dihydro-4H-pyrrolo[1,2-b]pyr...)
Affinity DataIC50: 2nMAssay Description:In vitro inhibitory activity against Class C (Amp-C) beta-LactamasesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM466999((2S)-2-fluoro-2-[[(2S,5R)-3-methyl-7-oxo-2-[(sulfa...)
Affinity DataIC50: 2.10nMAssay Description:A buffer consisting of 0.1 M sodium phosphate (pH 7.0), 10 mM NaHCO3, and 0.005% Triton X-100 was used for all enzymes. The chromogenic substrate nit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM466998((2S)-2-fluoro-2-[[(2S,5R)-2-(acetamidomethylcarbam...)
Affinity DataIC50: 3.10nMAssay Description:A buffer consisting of 0.1 M sodium phosphate (pH 7.0), 10 mM NaHCO3, and 0.005% Triton X-100 was used for all enzymes. The chromogenic substrate nit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM466979((2S)-2-fluoro-2-[[(2S,5R)-3-methyl-7-oxo-2-(2-sulf...)
Affinity DataIC50: 4.10nMAssay Description:A buffer consisting of 0.1 M sodium phosphate (pH 7.0), 10 mM NaHCO3, and 0.005% Triton X-100 was used for all enzymes. The chromogenic substrate nit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM466987((2S)-2-[[(2S,5R)-2-[(3-amino-3-oxo-propyl)carbamoy...)
Affinity DataIC50: 4.40nMAssay Description:A buffer consisting of 0.1 M sodium phosphate (pH 7.0), 10 mM NaHCO3, and 0.005% Triton X-100 was used for all enzymes. The chromogenic substrate nit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50149468(Sodium; (R)-6-[1-(5,6-dihydro-8H-imidazo[2,1-c][1,...)
Affinity DataIC50: 5nMAssay Description:In vitro inhibitory activity against Class C (Amp-C) beta-LactamasesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50149469(Sodium; (R)-7-oxo-6-[1-(5,6,7,8-tetrahydro-imidazo...)
Affinity DataIC50: 6nMAssay Description:In vitro inhibitory activity against Class C (Amp-C) beta-LactamasesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM466983((2S)-2-fluoro-2-[[(2S,5R)-2-[2-(methanesulfonamido...)
Affinity DataIC50: 7.30nMAssay Description:A buffer consisting of 0.1 M sodium phosphate (pH 7.0), 10 mM NaHCO3, and 0.005% Triton X-100 was used for all enzymes. The chromogenic substrate nit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50114518(Sodium; (R)-3-methanesulfonyl-5,5,8-trioxo-7-[1-py...)
Affinity DataIC50: 7.60nMAssay Description:Inhibitory activity against class A TEM-1 beta-lactamaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50114514(Sodium; (R)-3-[(E)-2-(2-guanidino-ethylcarbamoyl)-...)
Affinity DataIC50: 8.30nMAssay Description:Inhibitory activity against class A TEM-1 beta-lactamaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM466970(2-(((2S,5R)-2-(2-acetylhydrazinecarbonyl)-3-methyl...)
Affinity DataIC50: 8.30nMAssay Description:A buffer consisting of 0.1 M sodium phosphate (pH 7.0), 10 mM NaHCO3, and 0.005% Triton X-100 was used for all enzymes. The chromogenic substrate nit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM466984((2S)-2-fluoro-2-[[(2S,5R)-3-methyl-2-(oxazol-2-ylm...)
Affinity DataIC50: 9.30nMAssay Description:A buffer consisting of 0.1 M sodium phosphate (pH 7.0), 10 mM NaHCO3, and 0.005% Triton X-100 was used for all enzymes. The chromogenic substrate nit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50114516(Sodium; (R)-3-benzenesulfonyl-5,5,8-trioxo-7-[1-py...)
Affinity DataIC50: 9.40nMAssay Description:Inhibitory activity against class A TEM-1 beta-lactamaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM466989((2S)-2-fluoro-2-[[(2S,5R)-3-methyl-7-oxo-2-[2-(5-o...)
Affinity DataIC50: 10nMAssay Description:A buffer consisting of 0.1 M sodium phosphate (pH 7.0), 10 mM NaHCO3, and 0.005% Triton X-100 was used for all enzymes. The chromogenic substrate nit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM466965((2R)-{[(2S,5R)-2-carbamoyl-3-methyl-7-oxo-1,6-diaz...)
Affinity DataIC50: 11nMAssay Description:A buffer consisting of 0.1 M sodium phosphate (pH 7.0), 10 mM NaHCO3, and 0.005% Triton X-100 was used for all enzymes. The chromogenic substrate nit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM466967({[(2S,5R)-2-carbamoyl-3-methyl-7-oxo-1,6-diazabicy...)
Affinity DataIC50: 12nMAssay Description:A buffer consisting of 0.1 M sodium phosphate (pH 7.0), 10 mM NaHCO3, and 0.005% Triton X-100 was used for all enzymes. The chromogenic substrate nit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50114521(Sodium; (R)-5,5,8-trioxo-3-phenylsulfanyl-7-[1-pyr...)
Affinity DataIC50: 12nMAssay Description:Inhibitory activity against class A TEM-1 beta-lactamaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM466996((2S)-2-fluoro-2-[[(2S,5R)-2-(cyanomethylcarbamoyl)...)
Affinity DataIC50: 14nMAssay Description:A buffer consisting of 0.1 M sodium phosphate (pH 7.0), 10 mM NaHCO3, and 0.005% Triton X-100 was used for all enzymes. The chromogenic substrate nit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM466991((2S)-2-fluoro-2-[[(2S,5R)-3-methyl-7-oxo-2-[2-(sul...)
Affinity DataIC50: 14nMAssay Description:A buffer consisting of 0.1 M sodium phosphate (pH 7.0), 10 mM NaHCO3, and 0.005% Triton X-100 was used for all enzymes. The chromogenic substrate nit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50021959(antibiotic MM 14151 | CHEMBL777 | MM 14151 | clavu...)
Affinity DataIC50: 15nMAssay Description:Inhibitory activity against Escherichia coli TEM-3 Beta-lactamaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM466997((2S)-2-fluoro-2-[[(2S,5R)-2-(hydroxymethylcarbamoy...)
Affinity DataIC50: 17nMAssay Description:A buffer consisting of 0.1 M sodium phosphate (pH 7.0), 10 mM NaHCO3, and 0.005% Triton X-100 was used for all enzymes. The chromogenic substrate nit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50115618(2-[(2-Amino-thiazol-4-yl)-(dihydroxyboranylmethyl-...)
Affinity DataKi:  20nMAssay Description:Binding affinity towards AmpC beta-lactamase binding site from Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM39816(Acylglycineboronic acid, 15)
Affinity DataKi:  20nMpH: 7.0Assay Description:Enzyme inhibition assay using AmpC or TEM-1 from escherichia coli.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2011
Entry Details Article
PubMed
TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM466966({[(2S,5R)-2-carbamoyl-3-methyl-7-oxo-1,6-diazabicy...)
Affinity DataIC50: 20nMAssay Description:A buffer consisting of 0.1 M sodium phosphate (pH 7.0), 10 mM NaHCO3, and 0.005% Triton X-100 was used for all enzymes. The chromogenic substrate nit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM466974((2R)-2-(((2S,5R)-2-carbamoyl-3-cyclopropyl-7-oxo-1...)
Affinity DataIC50: 22nMAssay Description:A buffer consisting of 0.1 M sodium phosphate (pH 7.0), 10 mM NaHCO3, and 0.005% Triton X-100 was used for all enzymes. The chromogenic substrate nit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM466990((2S)-2-fluoro-2-[[(2S,5R)-3-methyl-7-oxo-2-(3-sulf...)
Affinity DataIC50: 22nMAssay Description:A buffer consisting of 0.1 M sodium phosphate (pH 7.0), 10 mM NaHCO3, and 0.005% Triton X-100 was used for all enzymes. The chromogenic substrate nit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM26139(Phenylboronic acid, 11 | 1-benzothiophen-2-ylboran...)
Affinity DataKi:  27nMAssay Description:Binding affinity towards AmpC beta-lactamase binding site from Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM26139(Phenylboronic acid, 11 | 1-benzothiophen-2-ylboran...)
Affinity DataKi:  27nMAssay Description:Inhibitory activity against Escherichia coli AmpC beta-lactamase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50067053(Sodium; (1S,5R)-2-benzyloxycarbonyl-4-[1-carbamoyl...)
Affinity DataIC50: 31nMAssay Description:Inhibitory activity against Escherichia coli TEM-3 Beta-lactamaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM39812(Acylglycineboronic acid, 10)
Affinity DataKi:  33nMpH: 7.0Assay Description:Enzyme inhibition assay using AmpC or TEM-1 from escherichia coli.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2011
Entry Details Article
PubMed
TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50067066(Sodium; (1S,4R,5S)-2-benzyloxycarbonyl-4-(1-methyl...)
Affinity DataIC50: 35nMAssay Description:Inhibitory activity against Escherichia coli TEM-3 Beta-lactamaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM467000(2-(((2S,5R)-2-carbamoyl-4-methyl-7-oxo-1,6-diazabi...)
Affinity DataIC50: 36nMAssay Description:A buffer consisting of 0.1 M sodium phosphate (pH 7.0), 10 mM NaHCO3, and 0.005% Triton X-100 was used for all enzymes. The chromogenic substrate nit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM466981((2S)-2-(((2S,5R)-2-((((S)-4,4-difluoropyrrolidin-2...)
Affinity DataIC50: 40nMAssay Description:A buffer consisting of 0.1 M sodium phosphate (pH 7.0), 10 mM NaHCO3, and 0.005% Triton X-100 was used for all enzymes. The chromogenic substrate nit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM466988((2S)-2-fluoro-2-[[(2S,5R)-3-methyl-7-oxo-2-[(5-oxo...)
Affinity DataIC50: 53nMAssay Description:A buffer consisting of 0.1 M sodium phosphate (pH 7.0), 10 mM NaHCO3, and 0.005% Triton X-100 was used for all enzymes. The chromogenic substrate nit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50114515(Sodium; (R)-3-[(E)-3-(4-methyl-piperazin-1-yl)-3-o...)
Affinity DataIC50: 53nMAssay Description:Inhibitory activity against class A TEM-1 beta-lactamaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM466982((2S)-2-fluoro-2-[[(2S,5R)-3-methyl-2-(oxetan-3-ylc...)
Affinity DataIC50: 54nMAssay Description:A buffer consisting of 0.1 M sodium phosphate (pH 7.0), 10 mM NaHCO3, and 0.005% Triton X-100 was used for all enzymes. The chromogenic substrate nit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM39849(Amide and sulfonamide derivatives, 33)
Affinity DataKi:  60nMpH: 7.0Assay Description:Inhibition assay against beta lactamase enzymes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2011
Entry Details Article
PubMed
TargetBeta-lactamase [1-20](Escherichia coli)
Basilea Pharmaceutica International

Curated by ChEMBL
LigandPNGBDBM50240480(CHEMBL158 | (2S,3S)-3-({(2Z)-2-(2-ammonio-1,3-thia...)
Affinity DataIC50: 60nMAssay Description:Inhibition of Escherichia coli ATCC 25922 AmpCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50076671((4R,6S)-3-{(2R,3R)-2-[((S)-1-Carboxy-2-methyl-prop...)
Affinity DataIC50: 68nMAssay Description:Inhibitory activity against AmpC (class C) beta-lactamaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50114524(Sodium; (R)-3-[(E)-2-(2-hydroxy-ethylcarbamoyl)-vi...)
Affinity DataIC50: 70nMAssay Description:Inhibitory activity against class A TEM-1 beta-lactamaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM39815(Acylglycineboronic acid, 14)
Affinity DataKi:  70nMpH: 7.0Assay Description:Enzyme inhibition assay using AmpC or TEM-1 from escherichia coli.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2011
Entry Details Article
PubMed
TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM466964((2S)-{[(2S,5R)-2-carbamoyl-3-methyl-7-oxo-1,6-diaz...)
Affinity DataIC50: 71nMAssay Description:A buffer consisting of 0.1 M sodium phosphate (pH 7.0), 10 mM NaHCO3, and 0.005% Triton X-100 was used for all enzymes. The chromogenic substrate nit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50149467((5R,6Z)-6-(6,7-dihydro-5H-cyclopenta-[d]imidazo[2,...)
Affinity DataIC50: 72nMAssay Description:In vitro inhibitory activity against Class A (Imi-1) beta-LactamasesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50114513(Sodium; (R)-5,5,8-trioxo-7-[1-pyridin-2-yl-meth-(Z...)
Affinity DataIC50: 78nMAssay Description:Inhibitory activity against class A TEM-1 beta-lactamaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50115616(Amide and sulfonamide derivatives, 2 | Aza-boronic...)
Affinity DataKi:  80nMAssay Description:Apparent inhibition constant against Escherichia coli AmpC beta-lactamaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-lactamase(Escherichia coli (strain K12))
Ucl School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50115616(Amide and sulfonamide derivatives, 2 | Aza-boronic...)
Affinity DataKi:  80nMpH: 7.0Assay Description:Inhibition assay against beta lactamase enzymes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
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