Compile Data Set for Download or QSAR
Report error Found 332 of affinity data for UniProtKB/TrEMBL: P06536
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM141379(US8916600, 13 | US9738632, Example 13)
Affinity DataIC50: 0.100nMAssay Description:Transrepression of glucocorticoid receptor in Wistar rat PBMC assessed as inhibition of LPS induced TNF alpha release preincubated for 45 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2019
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM86689(CAS_84371-65-3 | NSC_55245 | RU-486)
Affinity DataKi:  0.100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50250112(CHEMBL4072756)
Affinity DataIC50: 0.140nMAssay Description:Transrepression of glucocorticoid receptor in Wistar rat PBMC assessed as inhibition of LPS induced TNF alpha release preincubated for 45 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50354849(Flovent hfa | Cutivate | Flovent | Flovent diskus ...)
Affinity DataIC50: 0.140nMAssay Description:Transrepression of glucocorticoid receptor in Wistar rat PBMC assessed as inhibition of LPS induced TNF alpha release preincubated for 45 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2019
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50577704(CHEMBL4863316)
Affinity DataIC50: 0.158nMAssay Description:Agonist activity at glucocorticoid receptor in rat INS-1 832/13 cells transfected with CCL2-promoter luciferase plasmid construct assessed as reducti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50577694(CHEMBL4877227)
Affinity DataIC50: 0.200nMAssay Description:Agonist activity at glucocorticoid receptor in rat INS-1 832/13 cells transfected with CCL2-promoter luciferase plasmid construct assessed as reducti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50153512((9R,10S,11S,13S,14S,16R,17R)-9-Fluoro-11,17-dihydr...)
Affinity DataEC50:  0.200nMAssay Description:Repression of AP1-luciferase reporter activity in TPA-stimulated U2OS cells expressing rat glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50153512((9R,10S,11S,13S,14S,16R,17R)-9-Fluoro-11,17-dihydr...)
Affinity DataEC50:  0.200nMAssay Description:Effective concentration against MMTV in transactivation assay in U2OS cells expressing rat GRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM19235(2-{5-[4-({[(2,4-difluorophenyl)methyl](3-methanesu...)
Affinity DataIC50: 0.200nMpH: 8.0 T: 2°CAssay Description:For compounds able to displace the radiolabeled ligand (competitor) from the receptor an IC50 value (the concentration required to inhibit 50% of the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2007
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM19205((1R)-1-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4...)
Affinity DataIC50: 0.251nMAssay Description:Agonist activity at glucocorticoid receptor in rat INS-1 832/13 cells transfected with CCL2-promoter luciferase plasmid construct assessed as reducti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM86690(A-348441 | A 348441)
Affinity DataKi:  0.270nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2017
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM141378(US8916600, 12 | US9738632, Example 12)
Affinity DataIC50: 0.290nMAssay Description:Transrepression of glucocorticoid receptor in Wistar rat PBMC assessed as inhibition of LPS induced TNF alpha release preincubated for 45 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2019
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM141372(US8916600, 6 | US9738632, Example 6)
Affinity DataIC50: 0.300nMAssay Description:Transrepression of glucocorticoid receptor in Wistar rat PBMC assessed as inhibition of LPS induced TNF alpha release preincubated for 45 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2019
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50153512((9R,10S,11S,13S,14S,16R,17R)-9-Fluoro-11,17-dihydr...)
Affinity DataEC50:  0.300nMAssay Description:Repression of NF-kappaB-luciferase reporter activity in TPA stimulated U2OS cells expressing rat glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50594611(CHEMBL5196090)
Affinity DataIC50: 0.316nMAssay Description:Agonist activity at glucocorticoid receptor in rat INS-1 832/13 cells transfected with CCL2-promoter luciferase plasmid construct assessed as reducti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM141368(US8916600, 3 | US8916600, 2 | US9738632, Example 2)
Affinity DataIC50: 0.340nMAssay Description:Transrepression of glucocorticoid receptor in Wistar rat PBMC assessed as inhibition of LPS induced TNF alpha release preincubated for 45 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2019
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50577695(CHEMBL4853394)
Affinity DataEC50:  0.398nMAssay Description:Agonist activity at glucocorticoid receptor in rat INS-1 832/13 cells transfected with 3XGRE-promoter luciferase plasmid construct assessed as induct...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50594604(CHEMBL5173367)
Affinity DataEC50:  0.501nMAssay Description:Agonist activity at glucocorticoid receptor in rat INS-1 832/13 cells transfected with 3XGRE-promoter luciferase plasmid construct assessed as induct...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50250124(CHEMBL4099639)
Affinity DataIC50: 0.560nMAssay Description:Transrepression of glucocorticoid receptor in Wistar rat PBMC assessed as inhibition of LPS induced TNF alpha release preincubated for 45 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2019
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50594601(CHEMBL5181366)
Affinity DataIC50: 0.631nMAssay Description:Agonist activity at glucocorticoid receptor in rat INS-1 832/13 cells transfected with CCL2-promoter luciferase plasmid construct assessed as reducti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50153502(1-[(4aR,5S)-1-(4-Fluoro-phenyl)-4a-methyl-4,4a,5,6...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition against U2OS cells expressing rat Glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50354849(Flovent hfa | Cutivate | Flovent | Flovent diskus ...)
Affinity DataEC50:  0.760nMAssay Description:Transactivation activity at glucocorticoid receptor in rat H4II-E cells assessed as induction of tyrosine amino transferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50014432(CHEMBL3261407)
Affinity DataIC50: 0.900nMAssay Description:Agonist activity at glucocorticoid receptor in rat PBMC assessed as inhibition of LPS-stimulated TNF-alpha releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM19234(4-{[4-(3-{4-[(Benzyl{2-methyl-3-[(methylsulfonyl)a...)
Affinity DataIC50: 1nMpH: 8.0 T: 2°CAssay Description:For compounds able to displace the radiolabeled ligand (competitor) from the receptor an IC50 value (the concentration required to inhibit 50% of the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2007
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM18207(dexamethasone (tetramethyl-rhodamine conjugated ) ...)
Affinity DataIC50: 1.30nMAssay Description:Agonist activity at glucocorticoid receptor in rat INS-1 832/13 cells transfected with CCL2-promoter luciferase plasmid construct assessed as reducti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50153512((9R,10S,11S,13S,14S,16R,17R)-9-Fluoro-11,17-dihydr...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition against U2OS cells expressing rat Glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM18627(Mifeprex | (10S,11S,14S,15S,17R)-17-[4-(dimethylam...)
Affinity DataIC50: 1.40nMpH: 8.0 T: 2°CAssay Description:For compounds able to displace the radiolabeled ligand (competitor) from the receptor an IC50 value (the concentration required to inhibit 50% of the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2007
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50054959((4aS,4bR,5S,6aS,6bR,9aR)-4b-Fluoro-5-hydroxy-4a,6a...)
Affinity DataIC50: 1.60nMAssay Description:Steroid binding against the rat thymus glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50594607(CHEMBL5185246)
Affinity DataEC50:  1.60nMAssay Description:Agonist activity at glucocorticoid receptor in rat INS-1 832/13 cells transfected with 3XGRE-promoter luciferase plasmid construct assessed as induct...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50153501((4-Fluoro-phenyl)-[(4aR,5S)-1-(4-fluoro-phenyl)-4a...)
Affinity DataEC50:  1.70nMAssay Description:Repression of AP1-luciferase reporter activity in TPA-stimulated U2OS cells expressing rat glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50054966((4aS,4bR,5S,6aS,6bR,8R,9aR)-4b-Fluoro-5-hydroxy-4a...)
Affinity DataIC50: 1.70nMAssay Description:Steroid binding against the rat thymus glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50407988(CHEMBL2112857)
Affinity DataIC50: 1.80nMAssay Description:Steroid binding against the rat thymus glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50153508(Benzo[b]thiophen-3-yl-[(4aR,5S)-1-(4-fluoro-phenyl...)
Affinity DataEC50:  1.80nMAssay Description:Repression of AP1-luciferase reporter activity in TPA-stimulated U2OS cells expressing rat glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50153508(Benzo[b]thiophen-3-yl-[(4aR,5S)-1-(4-fluoro-phenyl...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition against U2OS cells expressing rat Glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM19238(2-{2-chloro-5-[4-({[(2,4-difluorophenyl)methyl](3-...)
Affinity DataIC50: 1.90nMpH: 8.0 T: 2°CAssay Description:For compounds able to displace the radiolabeled ligand (competitor) from the receptor an IC50 value (the concentration required to inhibit 50% of the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2007
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM18627(Mifeprex | (10S,11S,14S,15S,17R)-17-[4-(dimethylam...)
Affinity DataIC50: 1.90nMAssay Description:Antagonist activity against glucocorticoid receptor in rat H4-IIE cells assessed as inhibition of dexamethasone-induced receptor transactivation pre-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50577691(CHEMBL4850526)
Affinity DataIC50: 2nMAssay Description:Agonist activity at glucocorticoid receptor in rat INS-1 832/13 cells transfected with CCL2-promoter luciferase plasmid construct assessed as reducti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM18207(dexamethasone (tetramethyl-rhodamine conjugated ) ...)
Affinity DataEC50:  2nMAssay Description:Agonist activity at glucocorticoid receptor in rat INS-1 832/13 cells transfected with 3XGRE-promoter luciferase plasmid construct assessed as induct...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50054953((4aS,4bR,5S,6aS,6bR,8R,9aR)-4b-Fluoro-5-hydroxy-4a...)
Affinity DataIC50: 2.10nMAssay Description:Steroid binding against the rat thymus glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM19237(2-[4-(4-{[benzyl(3-methanesulfonamido-2-methylphen...)
Affinity DataIC50: 2.10nMpH: 8.0 T: 2°CAssay Description:For compounds able to displace the radiolabeled ligand (competitor) from the receptor an IC50 value (the concentration required to inhibit 50% of the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2007
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50054964((4aS,4bR,5S,6aS,6bR,8R,9aR,12S)-4b,12-Difluoro-6b-...)
Affinity DataIC50: 2.20nMAssay Description:Steroid binding against the rat thymus glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50054961((4aS,4bR,5S,6aS,6bR,9aR,12S)-4b,12-Difluoro-5-hydr...)
Affinity DataIC50: 2.20nMAssay Description:Steroid binding against the rat thymus glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50054955((4aS,4bR,5S,6aS,6bR,8R,9aR,12S)-4b,12-Difluoro-5-h...)
Affinity DataIC50: 2.20nMAssay Description:Steroid binding against the rat thymus glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50153504([(4aR,5S)-1-(4-Fluoro-phenyl)-4a-methyl-4,4a,5,6,7...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition against U2OS cells expressing rat Glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50369181(TIPREDANE)
Affinity DataIC50: 2.30nMAssay Description:Steroid binding against the rat thymus glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50153507([(4aR,5S)-1-(4-Fluoro-phenyl)-4a-methyl-4,4a,5,6,7...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition against U2OS cells expressing rat Glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM19233((2R,10S,11S,14S,15S)-14-hydroxy-15-methyl-2-[(4-me...)
Affinity DataIC50: 2.40nMpH: 8.0 T: 2°CAssay Description:For compounds able to displace the radiolabeled ligand (competitor) from the receptor an IC50 value (the concentration required to inhibit 50% of the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2007
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50054960((4aS,4bR,5S,6aS,6bR,8R,9aR,12S)-4b,12-Difluoro-5-h...)
Affinity DataIC50: 2.40nMAssay Description:Steroid binding against the rat thymus glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50153519([(4aR,5S)-1-(4-Fluoro-phenyl)-4a-methyl-4,4a,5,6,7...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition against U2OS cells expressing rat Glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM18627(Mifeprex | (10S,11S,14S,15S,17R)-17-[4-(dimethylam...)
Affinity DataEC50:  2.5nMAssay Description:Binding affinity to rat glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
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