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TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50582787(CHEMBL5088895)
Affinity DataKd:  0.0300nMAssay Description:Binding affinity of SARS-COV2 S-RBD by BLI assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50582782(CHEMBL5088125)
Affinity DataKd:  13nMAssay Description:Binding affinity to recombinant SARS-COV2 S-RBD incubated for 5 mins by microscale thermophoresis analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50568790(CHEMBL4869623)
Affinity DataKd:  23nMAssay Description:Binding affinity to SARS-CoV-2 spike glycoprotein S RBD at 25 degreeC by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50580230(CHEMBL5079992)
Affinity DataKd:  29nMAssay Description:Binding affinity to SARS-CoV-2 spike protein receptor-binding domain by biolayer interferometry (BLI) assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50580228(CHEMBL5085069)
Affinity DataKd:  31nMAssay Description:Binding affinity to SARS-CoV-2 spike protein receptor-binding domain by biolayer interferometry (BLI) assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50568789(Hypocrellin A | Rel-Hypocrellin A)
Affinity DataKd:  38nMAssay Description:Binding affinity to SARS-CoV-2 spike glycoprotein S RBD at 25 degreeC by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50568789(Hypocrellin A | Rel-Hypocrellin A)
Affinity DataIC50: 38nMAssay Description:Inhibition of spike glycoprotein S in SARS-CoV-2 pseudovirus infected in human 293T/ACE2 cells assessed as inhibition of viral infection pretreated t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50582783(CHEMBL5093610)
Affinity DataKd:  46nMAssay Description:Binding affinity to recombinant SARS-COV2 S-RBD incubated for 5 mins by microscale thermophoresis analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50422742(CHEMBL5274408)
Affinity DataIC50: 100nMAssay Description:Binding affinity of SARS-COV2 S-RBD by BLI assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50582779(CHEMBL5081573)
Affinity DataKd:  102nMAssay Description:Binding affinity to recombinant SARS-COV2 S-RBD incubated for 5 mins by microscale thermophoresis analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50580229(CHEMBL5078219)
Affinity DataKd:  105nMAssay Description:Binding affinity to SARS-CoV-2 spike protein receptor-binding domain by biolayer interferometry (BLI) assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50582778(CHEMBL5081268)
Affinity DataKd:  106nMAssay Description:Binding affinity to recombinant SARS-COV2 S-RBD incubated for 5 mins by microscale thermophoresis analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50568790(CHEMBL4869623)
Affinity DataIC50: 120nMAssay Description:Inhibition of spike glycoprotein S in SARS-CoV-2 pseudovirus infected in human 293T/ACE2 cells assessed as inhibition of viral infection pretreated t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM22985(Aralen | Chlorochin | CHLOROQUINE PHOSPHATE | Chlo...)
Affinity DataIC50: 160nMAssay Description:Inhibition of spike glycoprotein S in SARS-CoV-2 pseudovirus infected in human 293T/ACE2 cells assessed as inhibition of viral infection pretreated t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50568791(CHEMBL4861894)
Affinity DataIC50: 170nMAssay Description:Inhibition of spike glycoprotein S in SARS-CoV-2 pseudovirus infected in human 293T/ACE2 cells assessed as inhibition of viral infection pretreated t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM571393(4-chloro-N-(4-(((3aR,6aS)-tetrahydro-1H-furo[3,4-c...)
Affinity DataIC50: 200nMAssay Description:After infection, supernatants were removed, and cells were fixed with 4% formaldehyde for 24 hours prior to being removed from the BSL-3 facility. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM571394(4-chloro-N-(4-((4-hydroxypiperidin-1-yl)methyl)phe...)
Affinity DataIC50: 200nMAssay Description:After infection, supernatants were removed, and cells were fixed with 4% formaldehyde for 24 hours prior to being removed from the BSL-3 facility. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50582780(CHEMBL5091821)
Affinity DataKd:  245nMAssay Description:Binding affinity to recombinant SARS-COV2 S-RBD incubated for 5 mins by microscale thermophoresis analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM430624(NHC | EIDD-1931 | N4-Hydroxycytidine | Uridine, 4-...)
Affinity DataEC50:  300nMAssay Description:Determination of the inhibitory activity of compounds on the replication of 2019 novel coronavirus (SARS-CoV-2): anti-novel coronavirus activity test...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2024
Entry Details
US Patent

TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50571531(Gs 441524 | Gs-441524 | Gs441524 | US20240140975, ...)
Affinity DataEC50:  460nMAssay Description:Determination of the inhibitory activity of compounds on the replication of 2019 novel coronavirus (SARS-CoV-2): anti-novel coronavirus activity test...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2024
Entry Details
US Patent

TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50571531(Gs 441524 | Gs-441524 | Gs441524 | US20240140975, ...)
Affinity DataEC50:  470nMAssay Description:Determination of the inhibitory activity of compounds on the replication of 2019 novel coronavirus (SARS-CoV-2): anti-novel coronavirus activity test...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2024
Entry Details
US Patent

TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50582781(CHEMBL5078837)
Affinity DataKd:  541nMAssay Description:Binding affinity to recombinant SARS-COV2 S-RBD incubated for 5 mins by microscale thermophoresis analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50619251(CHEMBL5400898)
Affinity DataKd:  570nMAssay Description:Binding affinity to biotinylated recombinant SARS-CoV-2 spike protein RBD assessed as dissociation constant measured after 240 secs by biolayer inter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50421867(CHEMBL216826)
Affinity DataIC50: 600nMAssay Description:Inhibition of SARS-COV2 spike protein mediated infection of human ACE2 expressing cells at 50 uM by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM571386(N-(4-((1,4-oxazepan-4-yl)methyl)phenyl)-4-chlorobe...)
Affinity DataIC50: 600nMAssay Description:Cells were seeded in 24-well plates at a concentration of 7.5×104 cells/well. The following day, serial dilutions were performed in serum-free MEM me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM571390(N-(4-((7-oxa-2-azaspiro[3.5]nonan-2-yl)methyl)phen...)
Affinity DataIC50: 700nMAssay Description:After infection, supernatants were removed, and cells were fixed with 4% formaldehyde for 24 hours prior to being removed from the BSL-3 facility. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM571386(N-(4-((1,4-oxazepan-4-yl)methyl)phenyl)-4-chlorobe...)
Affinity DataIC50: 700nMAssay Description:After infection, supernatants were removed, and cells were fixed with 4% formaldehyde for 24 hours prior to being removed from the BSL-3 facility. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM571396(4-chloro-N-(4-((4-methylpiperazin-1-yl)methyl)phen...)
Affinity DataIC50: 700nMAssay Description:After infection, supernatants were removed, and cells were fixed with 4% formaldehyde for 24 hours prior to being removed from the BSL-3 facility. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50591871(CHEMBL5195094)
Affinity DataKd:  780nMAssay Description:Binding affinity to SARS-CoV-2 Spike trimer protein by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM571387(N-(4-((2-oxa-6-azaspiro[3.3]heptan-6-yl)methyl)phe...)
Affinity DataIC50: 1.00E+3nMAssay Description:The SARS-CoV-2 isolate BetaCoV/France/IDF0372/2020 (SARS-CoV-2 Paris) was supplied by the National Reference Centre for Respiratory Viruses hosted by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM571389(2-chloro-N-(4-(morpholinomethyl)phenyl)pyrimidine-...)
Affinity DataIC50: 1.20E+3nMAssay Description:After infection, supernatants were removed, and cells were fixed with 4% formaldehyde for 24 hours prior to being removed from the BSL-3 facility. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM571387(N-(4-((2-oxa-6-azaspiro[3.3]heptan-6-yl)methyl)phe...)
Affinity DataIC50: 1.20E+3nMAssay Description:After infection, supernatants were removed, and cells were fixed with 4% formaldehyde for 24 hours prior to being removed from the BSL-3 facility. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM571393(4-chloro-N-(4-(((3aR,6aS)-tetrahydro-1H-furo[3,4-c...)
Affinity DataIC50: 1.30E+3nMAssay Description:Cells were seeded in 24-well plates at a concentration of 7.5×104 cells/well. The following day, serial dilutions were performed in serum-free MEM me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50582786(CHEMBL5094988)
Affinity DataKd:  1.30E+3nMAssay Description:Binding affinity of SARS-COV2 S-RBD by BLI assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM571390(N-(4-((7-oxa-2-azaspiro[3.5]nonan-2-yl)methyl)phen...)
Affinity DataIC50: 1.40E+3nMAssay Description:The SARS-CoV-2 isolate BetaCoV/France/IDF0372/2020 (SARS-CoV-2 Paris) was supplied by the National Reference Centre for Respiratory Viruses hosted by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM571394(4-chloro-N-(4-((4-hydroxypiperidin-1-yl)methyl)phe...)
Affinity DataIC50: 1.60E+3nMAssay Description:Cells were seeded in 24-well plates at a concentration of 7.5×104 cells/well. The following day, serial dilutions were performed in serum-free MEM me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM571386(N-(4-((1,4-oxazepan-4-yl)methyl)phenyl)-4-chlorobe...)
Affinity DataIC50: 1.80E+3nMAssay Description:The SARS-CoV-2 isolate BetaCoV/France/IDF0372/2020 (SARS-CoV-2 Paris) was supplied by the National Reference Centre for Respiratory Viruses hosted by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50640006(CHEMBL5559840)
Affinity DataKd:  1.87E+3nMAssay Description:Binding affinity to RBD domain of SARS-CoV-2 spike protein assessed as dissociation constant by Isothermal Titration CalorimetryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50582784(CHEMBL5094981)
Affinity DataKd:  2.00E+3nMAssay Description:Inhibition of SARS-COV2 spike protein mediated infection of human ACE2 expressing cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50582786(CHEMBL5094988)
Affinity DataKd:  2.00E+3nMAssay Description:Inhibition of SARS-COV2 spike protein mediated infection of human ACE2 expressing cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM571390(N-(4-((7-oxa-2-azaspiro[3.5]nonan-2-yl)methyl)phen...)
Affinity DataIC50: 2.10E+3nMAssay Description:Cells were seeded in 24-well plates at a concentration of 7.5×104 cells/well. The following day, serial dilutions were performed in serum-free MEM me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM571394(4-chloro-N-(4-((4-hydroxypiperidin-1-yl)methyl)phe...)
Affinity DataIC50: 2.10E+3nMAssay Description:The SARS-CoV-2 isolate BetaCoV/France/IDF0372/2020 (SARS-CoV-2 Paris) was supplied by the National Reference Centre for Respiratory Viruses hosted by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50640000(CHEMBL5568325)
Affinity DataKd:  2.11E+3nMAssay Description:Binding affinity to RBD domain of SARS-CoV-2 spike protein assessed as dissociation constant by Isothermal Titration CalorimetryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50582787(CHEMBL5088895)
Affinity DataKd:  2.20E+3nMAssay Description:Binding affinity to biotinylated recombinant SARS-COV2 S-RBD by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50604261(CHEMBL5183417)
Affinity DataKd:  2.52E+3nMAssay Description:Binding affinity to SARS-CoV-2 spike protein assessed as Kd by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM571396(4-chloro-N-(4-((4-methylpiperazin-1-yl)methyl)phen...)
Affinity DataIC50: 2.70E+3nMAssay Description:The SARS-CoV-2 isolate BetaCoV/France/IDF0372/2020 (SARS-CoV-2 Paris) was supplied by the National Reference Centre for Respiratory Viruses hosted by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM571393(4-chloro-N-(4-(((3aR,6aS)-tetrahydro-1H-furo[3,4-c...)
Affinity DataIC50: 2.80E+3nMAssay Description:The SARS-CoV-2 isolate BetaCoV/France/IDF0372/2020 (SARS-CoV-2 Paris) was supplied by the National Reference Centre for Respiratory Viruses hosted by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM571391(N-(4-((1-oxa-7-azaspiro[4.4]nonan-7-yl)methyl)phen...)
Affinity DataIC50: 2.90E+3nMAssay Description:Cells were seeded in 24-well plates at a concentration of 7.5×104 cells/well. The following day, serial dilutions were performed in serum-free MEM me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50590308(CHEMBL5201689)
Affinity DataKi:  3.02E+3nMAssay Description:Competitive inhibition of biotinylated heparin binding to His-tagged wild type SARS-COV-2 spike protein assessed inhibition constant incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetSpike glycoprotein(2019-nCoV)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM571392(N-(4-(((1R,5S)-3-oxa-7-azabicyclo[3.3.1]nonan-7-yl...)
Affinity DataIC50: 3.10E+3nMAssay Description:Cells were seeded in 24-well plates at a concentration of 7.5×104 cells/well. The following day, serial dilutions were performed in serum-free MEM me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

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