BDBM430624 Beta-D-N4-hydroxycytidine::EIDD-1931::N(4)-Hydroxycytidine::N4-Hydroxycytidine::NHC::US20240034730, Compound EIDD-1931::Uridine, 4-oxime

SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ccc(NO)nc1=O

InChI Key InChIKey=XCUAIINAJCDIPM-XVFCMESISA-N

Data  4 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 430624   

TargetOrf1a protein(MERS-CoV)
University of North Carolina At Chapel Hill

LigandPNGBDBM430624(Beta-D-N4-hydroxycytidine | EIDD-1931 | N(4)-Hydro...)
Affinity DataIC50:  150nMAssay Description:At 48 hours prior to infection, Calu-3 2B4 cells were plated in a 96-well black-walled clear bottom plate at 5x104 cells/well. A 10 mM stock of NHC w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of North Carolina At Chapel Hill

LigandPNGBDBM430624(Beta-D-N4-hydroxycytidine | EIDD-1931 | N(4)-Hydro...)
Affinity DataIC50:  300nMAssay Description:Vero E6 cells were plated at 20,000 cells/well in a 96-well plate. 24hr later, medium containing a dose response of NHC was added concurrent with SAR...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of North Carolina At Chapel Hill

LigandPNGBDBM430624(Beta-D-N4-hydroxycytidine | EIDD-1931 | N(4)-Hydro...)
Affinity DataEC50:  300nMAssay Description:To evaluate the anti-HSV activity of 1, 17 or Brequinar by plaque reduction assays (PRA), Vero cells were seeded in 24-well plates at a density of 70...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetReplicase polyprotein 1ab(2019-nCoV)
University of North Carolina At Chapel Hill

LigandPNGBDBM430624(Beta-D-N4-hydroxycytidine | EIDD-1931 | N(4)-Hydro...)
Affinity DataIC50:  90nMAssay Description:Calu-3 2B4 cells were adsorbed with MOI 0.1 PFU/cell of SARS-CoV-2 (2019-nCoV/USA-WA1/2020 strain) at 37°C. Plates were manually rocked every 10 min ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of North Carolina At Chapel Hill

LigandPNGBDBM430624(Beta-D-N4-hydroxycytidine | EIDD-1931 | N(4)-Hydro...)
Affinity DataIC50:  80nMAssay Description:Calu-3 2B4 cells were adsorbed with MOI 0.1 PFU/cell of SARS-CoV-2 (2019-nCoV/USA-WA1/2020 strain) at 37°C. Plates were manually rocked every 10 min ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed