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Report error Found 102 of affinity data for UniProtKB/TrEMBL: P21761
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50072394(PROTIRELIN | ABBOTT-38579 | A-38579 | 1-[3-(1H-4-i...)
Affinity DataEC50:  0.490nMAssay Description:Ability to activate thyroliberin endocrine receptor (TRH-R) using AtT-20 mouse pituitary tumor cells prelabelled with myo-[3H] inositolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50072394(PROTIRELIN | ABBOTT-38579 | A-38579 | 1-[3-(1H-4-i...)
Affinity DataEC50:  0.680nMAssay Description:Effective concentration required to activate TRH-R receptor in AtT-20 mouse pituitary tumor cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2012
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50072394(PROTIRELIN | ABBOTT-38579 | A-38579 | 1-[3-(1H-4-i...)
Affinity DataEC50:  1nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50072394(PROTIRELIN | ABBOTT-38579 | A-38579 | 1-[3-(1H-4-i...)
Affinity DataEC50:  1nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as induction of changes in intracellular Ca2+ level by FLIPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50050531(1-[3-(1-methyl-4-imidazolyl)-2-[2-oxo-(5S)-dihydro...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity against TRH-R receptor in AtT-20 mouse pituitary tumor cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2012
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50072394(PROTIRELIN | ABBOTT-38579 | A-38579 | 1-[3-(1H-4-i...)
Affinity DataIC50: 2.60nMAssay Description:Displacement of [3H]-1-MeHis-TRH from mouse TRH-R1 expressed in HEK293 cells incubated up to 4 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50072394(PROTIRELIN | ABBOTT-38579 | A-38579 | 1-[3-(1H-4-i...)
Affinity DataEC50:  3.20nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50158418(CHEMBL3780746)
Affinity DataEC50:  3.40nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50158395(CHEMBL3782037)
Affinity DataEC50:  4.90nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50158394(CHEMBL3780645)
Affinity DataEC50:  5.90nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50072394(PROTIRELIN | ABBOTT-38579 | A-38579 | 1-[3-(1H-4-i...)
Affinity DataKi:  10nMAssay Description:Binding affinity against TRH-R receptor in AtT-20 mouse pituitary tumor cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2012
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50158409(CHEMBL3779931)
Affinity DataEC50:  12nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50158395(CHEMBL3782037)
Affinity DataEC50:  13nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50158401(CHEMBL3780549)
Affinity DataEC50:  15nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM86214(NSC_32281 | CAS_32281 | TRH | Phe2TRH)
Affinity DataKi:  15nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2012
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50109028(CHEMBL3600447)
Affinity DataEC50:  17nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as induction of changes in intracellular Ca2+ level by FLIPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50072394(PROTIRELIN | ABBOTT-38579 | A-38579 | 1-[3-(1H-4-i...)
Affinity DataKi:  23nMAssay Description:Ability to bind thyroliberin endocrine receptor (TRH-R) using AtT-20 mouse pituitary tumor cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50072394(PROTIRELIN | ABBOTT-38579 | A-38579 | 1-[3-(1H-4-i...)
Affinity DataIC50: 26nMAssay Description:Displacement of [3H]-Me-His-TRH from mouse TRH-R1 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50158396(CHEMBL3781773)
Affinity DataEC50:  27nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50158418(CHEMBL3780746)
Affinity DataEC50:  28nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50158394(CHEMBL3780645)
Affinity DataEC50:  31nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50158404(CHEMBL3780373)
Affinity DataEC50:  32nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50158401(CHEMBL3780549)
Affinity DataEC50:  53nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50109039(CHEMBL3600454)
Affinity DataEC50:  77nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as induction of changes in intracellular Ca2+ level by FLIPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50050532(1-[2-[2-oxo-(5S)-dihydro-2H-5-pyrrolylcarboxamido]...)
Affinity DataEC50:  110nMAssay Description:Effective concentration required to activate TRH-R receptor in AtT-20 mouse pituitary tumor cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2012
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50109027(CHEMBL3600446)
Affinity DataEC50:  150nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as induction of changes in intracellular Ca2+ level by FLIPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50158418(CHEMBL3780746)
Affinity DataIC50: 170nMAssay Description:Displacement of [3H]-Me-His-TRH from mouse TRH-R1 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50158399(CHEMBL3780802)
Affinity DataEC50:  170nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50158399(CHEMBL3780802)
Affinity DataEC50:  249nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50158398(CHEMBL3780633)
Affinity DataEC50:  272nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50109040(CHEMBL3601782)
Affinity DataEC50:  287nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as induction of changes in intracellular Ca2+ level by FLIPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50050529((S)-1-[2-((5R,7R)-2,6-Dioxo-1,7-diaza-spiro[4.4]no...)
Affinity DataEC50:  290nMAssay Description:Effective concentration required to activate TRH-R receptor in AtT-20 mouse pituitary tumor cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2012
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50158532(CHEMBL3781522)
Affinity DataEC50:  320nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50158394(CHEMBL3780645)
Affinity DataIC50: 324nMAssay Description:Displacement of [3H]-Me-His-TRH from mouse TRH-R1 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50158396(CHEMBL3781773)
Affinity DataEC50:  339nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50109022(CHEMBL3601785)
Affinity DataEC50:  340nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as induction of changes in intracellular Ca2+ level by FLIPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50072395(1-[3-cyclohexyl-2-(5-oxotetrahydro-1H-2-pyrrolylca...)
Affinity DataEC50:  430nMAssay Description:Ability to activate thyroliberin endocrine receptor (TRH-R) using AtT-20 mouse pituitary tumor cells prelabelled with myo-[3H] inositolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50109041(CHEMBL3601781)
Affinity DataEC50:  498nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as induction of changes in intracellular Ca2+ level by FLIPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50109025(CHEMBL3600444)
Affinity DataEC50:  740nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as induction of changes in intracellular Ca2+ level by FLIPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50158400(CHEMBL3780191)
Affinity DataEC50:  780nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50158532(CHEMBL3781522)
Affinity DataEC50:  790nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50109034(CHEMBL3600449)
Affinity DataEC50:  940nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as induction of changes in intracellular Ca2+ level by FLIPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50109026(CHEMBL3600445)
Affinity DataEC50:  980nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as induction of changes in intracellular Ca2+ level by FLIPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50109035(CHEMBL3600450)
Affinity DataEC50:  1.00E+3nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as induction of changes in intracellular Ca2+ level by FLIPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50158395(CHEMBL3782037)
Affinity DataIC50: 1.18E+3nMAssay Description:Displacement of [3H]-Me-His-TRH from mouse TRH-R1 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2017
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50109017(CHEMBL3601783)
Affinity DataEC50:  1.41E+3nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as induction of changes in intracellular Ca2+ level by FLIPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50072396(7-cyclohexyl-6-(2,6-dioxo-1,7-diazaspiro[4.4]non-7...)
Affinity DataKi:  1.50E+3nMAssay Description:Ability to bind thyroliberin endocrine receptor (TRH-R) using AtT-20 mouse pituitary tumor cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50050532(1-[2-[2-oxo-(5S)-dihydro-2H-5-pyrrolylcarboxamido]...)
Affinity DataKi:  1.50E+3nMAssay Description:Binding affinity against TRH-R receptor in AtT-20 mouse pituitary tumor cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2012
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50109033(CHEMBL3600448)
Affinity DataEC50:  1.56E+3nMAssay Description:Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as induction of changes in intracellular Ca2+ level by FLIPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Mouse)
Washington University

Curated by ChEMBL
LigandPNGBDBM50072396(7-cyclohexyl-6-(2,6-dioxo-1,7-diazaspiro[4.4]non-7...)
Affinity DataEC50:  1.80E+3nMAssay Description:Ability to activate thyroliberin endocrine receptor (TRH-R) using AtT-20 mouse pituitary tumor cells prelabelled with myo-[3H] inositolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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