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Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50240412(3-(4-{7-[4-(5-carbamoyl-1H-3-indolyl)-3-cyclohexen...)
Affinity DataIC50: 0.0500nMAssay Description:Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50240412(3-(4-{7-[4-(5-carbamoyl-1H-3-indolyl)-3-cyclohexen...)
Affinity DataIC50: 0.0500nMAssay Description:Inhibitory activity against 5-hydroxytryptamine 1D receptor subtypeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50413549(CHEMBL513715)
Affinity DataKi:  0.0501nMAssay Description:Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50413549(CHEMBL513715)
Affinity DataKi:  0.0501nMAssay Description:Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50417409(CHEMBL1290487)
Affinity DataKi:  0.0794nMAssay Description:Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50413560(CHEMBL469374)
Affinity DataKi:  0.0794nMAssay Description:Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50054988(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-N-[4-(4-{2-...)
Affinity DataKi:  0.0900nMAssay Description:Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50417420(CHEMBL1290486)
Affinity DataKi:  0.100nMAssay Description:Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50083658(4-Benzyl-1-[3-(5-[1,2,4]triazol-4-yl-1H-indol-3-yl...)
Affinity DataIC50: 0.100nMAssay Description:Ability to displace [3H]-5-HT from recombinant human 5-hydroxytryptamine 1D receptor stably expressed in CHO cells determined in vitroMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50060440(3-[3-(4-Benzyl-piperazin-1-yl)-propyl]-5-[1,2,4]tr...)
Affinity DataIC50: 0.100nMAssay Description:Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50074186(3-{3-[4-(4-Fluoro-benzyl)-piperazin-1-yl]-propyl}-...)
Affinity DataIC50: 0.100nMAssay Description:Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50060440(3-[3-(4-Benzyl-piperazin-1-yl)-propyl]-5-[1,2,4]tr...)
Affinity DataEC50:  0.100nMAssay Description:Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50077807(3-{3-[4-Fluoro-4-(2-fluoro-benzyl)-piperidin-1-yl]...)
Affinity DataIC50: 0.100nMAssay Description:Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50413550(CHEMBL469345)
Affinity DataKi:  0.100nMAssay Description:Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50060440(3-[3-(4-Benzyl-piperazin-1-yl)-propyl]-5-[1,2,4]tr...)
Affinity DataEC50:  0.100nMAssay Description:Agonist induced [35S]GTP-gamma-S, binding in CHO cells expressing 5-HT 1d receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50413077(CHEMBL522257)
Affinity DataKi:  0.100nMAssay Description:Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50285314(3-(4-{8-[4-(5-carbamoyl-1H-3-indolyl)-3-cyclohexen...)
Affinity DataIC50: 0.110nMAssay Description:Inhibitory activity against 5-hydroxytryptamine 1D receptor subtypeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50054981(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-N-(4-{2-[3-...)
Affinity DataKi:  0.110nMAssay Description:Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50054974(2-(5-{4-[3-(2-Amino-ethyl)-1H-indol-5-yloxymethyl]...)
Affinity DataKi:  0.110nMAssay Description:Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50054974(2-(5-{4-[3-(2-Amino-ethyl)-1H-indol-5-yloxymethyl]...)
Affinity DataKi:  0.110nMAssay Description:Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1D receptor expressed in CHOK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM79215(SMR001230745 | N-[4-methoxy-3-(4-methylpiperazin-1...)
Affinity DataKi:  0.120nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM79215(SMR001230745 | N-[4-methoxy-3-(4-methylpiperazin-1...)
Affinity DataKi:  0.126nMAssay Description:Binding affinity against 5-hydroxytryptamine 1D receptor betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50417411(CHEMBL1290715)
Affinity DataKi:  0.126nMAssay Description:Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50417424(CHEMBL1289394)
Affinity DataKi:  0.126nMAssay Description:Antagonist activity at human 5-HT1D receptor expressed in CHO cells assessed as inhibition of GTPgammaS binding by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50280055(7-Methyl-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-...)
Affinity DataKi:  0.130nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50280055(7-Methyl-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-...)
Affinity DataKi:  0.130nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2011
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50060440(3-[3-(4-Benzyl-piperazin-1-yl)-propyl]-5-[1,2,4]tr...)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of human 5HT1D expressed in CHO cells by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50060440(3-[3-(4-Benzyl-piperazin-1-yl)-propyl]-5-[1,2,4]tr...)
Affinity DataIC50: 0.140nMAssay Description:Displacement of specific [3H]5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50060440(3-[3-(4-Benzyl-piperazin-1-yl)-propyl]-5-[1,2,4]tr...)
Affinity DataIC50: 0.140nMAssay Description:Displacement of [3H]-5-HT from human 5HT-1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2016
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50413084(CHEMBL521506)
Affinity DataKi:  0.158nMAssay Description:Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50413555(CHEMBL469568)
Affinity DataKi:  0.158nMAssay Description:Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50412441(SB-744185 | CHEMBL490417)
Affinity DataKi:  0.158nMAssay Description:Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50413078(CHEMBL491839)
Affinity DataKi:  0.158nMAssay Description:Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50054987(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-1-(4-{2-[3-...)
Affinity DataKi:  0.160nMAssay Description:Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50054976(2-[3-(2-Amino-ethyl)-1H-indol-5-yloxy]-N-{2-[3-(2-...)
Affinity DataKi:  0.180nMAssay Description:Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1D receptor in CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50413698(CHEMBL459282)
Affinity DataKi:  0.200nMAssay Description:Displacement of 3H]5HT from human 5HT1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50412441(SB-744185 | CHEMBL490417)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]5HT from human cloned 5HT1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50413085(CHEMBL485491)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50413087(CHEMBL497980)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50074205(N-(3-{4-[3-(5-[1,2,4]Triazol-4-yl-1H-indol-3-yl)-p...)
Affinity DataEC50:  0.200nMAssay Description:Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50413079(CHEMBL444398)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50060440(3-[3-(4-Benzyl-piperazin-1-yl)-propyl]-5-[1,2,4]tr...)
Affinity DataEC50:  0.200nMAssay Description:Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50413553(CHEMBL472290)
Affinity DataKi:  0.200nMAssay Description:Antagonist activity at human 5HT1D assessed as GTPgammaS binding by scintillation proximity assay in presence of 5-HTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50074188(2-Phenyl-2-{4-[3-(5-[1,2,4]triazol-4-yl-1H-indol-3...)
Affinity DataIC50: 0.200nMAssay Description:Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50060440(3-[3-(4-Benzyl-piperazin-1-yl)-propyl]-5-[1,2,4]tr...)
Affinity DataIC50: 0.200nMAssay Description:Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50074205(N-(3-{4-[3-(5-[1,2,4]Triazol-4-yl-1H-indol-3-yl)-p...)
Affinity DataIC50: 0.200nMAssay Description:Displacement of [3H]5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50077814(3-{3-[4-Fluoro-4-(2-trifluoromethyl-benzyl)-piperi...)
Affinity DataEC50:  0.200nMAssay Description:Agonist-induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50413075(CHEMBL489394)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]5HT from human 5HT1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50074188(2-Phenyl-2-{4-[3-(5-[1,2,4]triazol-4-yl-1H-indol-3...)
Affinity DataEC50:  0.200nMAssay Description:Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the human 5-hydroxytryptamine 1D receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Theravance

Curated by ChEMBL
LigandPNGBDBM50060440(3-[3-(4-Benzyl-piperazin-1-yl)-propyl]-5-[1,2,4]tr...)
Affinity DataIC50: 0.200nMAssay Description:Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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