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Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM35247(3-(phenylsulfonyl)-1H-indole, 18i)
Affinity DataAssay Description:IC50 Values were obtained from inhibition of norepinephrine uptake in MDCK-Net6 cells, stably transfected with the human NET. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM255474(US9481688, 1 | US9481688, 3)
Affinity DataEC50: >1.00E+4nMAssay Description:Further, the compounds of the invention may be tested in binding assays and functional activity assays by well known methods for other physiologicall...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2017
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM50373192(CHEMBL405519 | US10729710, Compound (I) | US202403...)
Affinity DataEC50:  2.90E+3nMAssay Description:Evaluation of the affinity of compounds for the human 5-HT2B receptor was determined in a radioligand binding assay at Eurofins/Cerep (France). Membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2025
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM453276(US10729710, Compound (Ia) | US20240352055, Compoun...)
Affinity DataEC50: >6.00E+3nMAssay Description:Evaluation of the affinity of compounds for the human 5-HT2B receptor was determined in a radioligand binding assay at Eurofins/Cerep (France). Membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2025
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM453277(US10729710, Compound (Ib) | US20240352055, Compoun...)
Affinity DataEC50:  3.80nMAssay Description:Evaluation of the affinity of compounds for the human 5-HT2B receptor was determined in a radioligand binding assay at Eurofins/Cerep (France). Membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2025
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM50373192(CHEMBL405519 | US10729710, Compound (I) | US202403...)
Affinity DataEC50:  2.90E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM763779(US12384765, Compound (Ia))
Affinity DataEC50: >6.00E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM453277(US10729710, Compound (Ib) | US20240352055, Compoun...)
Affinity DataEC50:  3.80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM50459707(CHEMBL4208452 | US10836764, Compound 115)
Affinity DataEC50:  115nMAssay Description:Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM50459709(CHEMBL4209052 | US10836764, Compound 137)
Affinity DataEC50:  4.02E+3nMAssay Description:Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM50459712(CHEMBL4218374 | US10836764, Compound 173)
Affinity DataEC50:  1.29E+3nMAssay Description:Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM50459713(CHEMBL4213447 | US10836764, Compound 176)
Affinity DataEC50:  165nMAssay Description:Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM50459711(CHEMBL4217846)
Affinity DataEC50:  779nMAssay Description:Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM50459717(CHEMBL4209572)
Affinity DataEC50:  61nMAssay Description:Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM50459715(CHEMBL4213971)
Affinity DataEC50:  489nMAssay Description:Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM50459710(CHEMBL4212834 | US10836764, Compound 128)
Affinity DataEC50:  307nMAssay Description:Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM50459718(CHEMBL4213379 | US10836764, Compound 106)
Affinity DataEC50:  758nMAssay Description:Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM50459708(CHEMBL4206126 | US10836764, Compound 152)
Affinity DataEC50:  1.29E+3nMAssay Description:Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM50459714(CHEMBL4204710 | US10836764, Compound 149)
Affinity DataEC50:  22nMAssay Description:Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM50459716(CHEMBL4217787 | US10836764, Compound 121)
Affinity DataEC50:  478nMAssay Description:Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataEC50:  4.5nMAssay Description:Agonist activity at human 5-HT2BR expressed in CHO cells assessed as induction of IP1 accumulation after 30 mins by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM50161641((1R,S)-7,8-dichloro-2,3,4,5-tetrahydro-1-methyl-1H...)
Affinity DataEC50:  50nMAssay Description:Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM50161636((1S)-8,9-dichloro-2,3,4,5-tetrahydro-1-methyl-1H-3...)
Affinity DataEC50:  1.26E+3nMAssay Description:Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM50161646((R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  794nMAssay Description:Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM50161638((1R,S)-8-chloro-7-methoxy-2,3,4,5-tetrahydro-1-met...)
Affinity DataEC50:  63nMAssay Description:Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM50161649(1-Methyl-8-trifluoromethyl-2,3,4,5-tetrahydro-1H-b...)
Affinity DataEC50:  794nMAssay Description:Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM50161648(6,8-Dichloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  794nMAssay Description:Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM50161633(8-Chloro-7-fluoro-1-methyl-2,3,4,5-tetrahydro-1H-b...)
Affinity DataEC50:  316nMAssay Description:Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM50161629(8,9-Dichloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[...)
Affinity DataEC50:  1.59E+3nMAssay Description:Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM50161645(7-Chloro-2,3,4,5-tetrahydro-1H-benzo[d]azepine | C...)
Affinity DataEC50:  1.00E+3nMAssay Description:Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM50161647((1S)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...)
Affinity DataEC50:  1.26E+3nMAssay Description:Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM50161642((1R,S)-7-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-b...)
Affinity DataEC50:  501nMAssay Description:Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM50161625(1-Methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine | C...)
Affinity DataEC50:  3.98E+3nMAssay Description:Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM50161621(6-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]az...)
Affinity DataEC50: <1.00E+4nMAssay Description:Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM50161622(8-Bromo-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]aze...)
Affinity DataEC50:  2.00E+3nMAssay Description:Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM50161634((1R)-8,9-dichloro-2,3,4,5-tetrahydro-1-methyl-1H-3...)
Affinity DataEC50: <1.00E+4nMAssay Description:Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM50477830(CHEMBL253806)
Affinity DataEC50:  398nMAssay Description:Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM50477831(CHEMBL253591)
Affinity DataEC50:  40nMAssay Description:Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM50477832(CHEMBL254215)
Affinity DataEC50:  794nMAssay Description:Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM50477827(CHEMBL253809)
Affinity DataEC50:  251nMAssay Description:Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM50144841((S)-1-(6-chloro-5-fluoro-1H-indol-1-yl)propan-2-am...)
Affinity DataEC50:  1.60nMAssay Description:Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM10755([3H]-5-HT | 5-Hydroxy Tryptamine | 2-imino-1-methy...)
Affinity DataEC50:  25nMAssay Description:Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM50477834(CHEMBL398926)
Affinity DataEC50: <1.00E+4nMAssay Description:Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM50161628(8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]az...)
Affinity DataEC50:  1.00E+3nMAssay Description:Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM50477829(CHEMBL400600)
Affinity DataEC50:  40nMAssay Description:Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM50477836(CHEMBL253155)
Affinity DataEC50: <1.00E+4nMAssay Description:Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM50161639(8-Chloro-9-fluoro-1-methyl-2,3,4,5-tetrahydro-1H-b...)
Affinity DataEC50:  2.51E+3nMAssay Description:Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM85530(Norfenfluramine (+) | Norfenfluramine | Nor-dexfen...)
Affinity DataEC50:  16nMAssay Description:Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM50477835(CHEMBL254009)
Affinity DataEC50:  501nMAssay Description:Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Wyeth Research

LigandPNGBDBM50161644(7-methoxy-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]a...)
Affinity DataEC50: <1.00E+4nMAssay Description:Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
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