Compile Data Set for Download or QSAR
Report error Found 2631 for UniProtKB: P54750
LigandPNGBDBM168129(US9073936, 4 | US9598426, 4)
Affinity DataKi:  0.100nMAssay Description:Assay: The following phosphodiesterase enzymes may be used: 3′,5′-cyclic-nucleotide-specific bovine brain phosphodiesterase (Sigma, St. L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

LigandPNGBDBM168129(US9073936, 4 | US9598426, 4)
Affinity DataKi:  0.100nM ΔG°:  -58.0kJ/molepH: 7.5 T: 2°CAssay Description:Materials: All chemicals are available from Sigma-Aldrich (St. Louis, Mo.) except for IMAP reagents (reaction buffer, binding buffer, FL-GMP and IMAP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2016
Entry Details
US Patent

LigandPNGBDBM580557(US11491140, Example 132 | 5-(2-ethoxy-3-pyridyl)-3...)
Affinity DataIC50: 0.140nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
US Patent

LigandPNGBDBM501502(5-(2-ethoxy-3-pyridyl)-3-methyl-N-[1- methylimidaz...)
Affinity DataIC50: 0.140nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM279101(5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1-methylimidaz...)
Affinity DataIC50: 0.140nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
US Patent

LigandPNGBDBM279101(5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1-methylimidaz...)
Affinity DataIC50: 0.140nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

LigandPNGBDBM279101(5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1-methylimidaz...)
Affinity DataIC50: 0.140nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
US Patent

LigandPNGBDBM279101(5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1-methylimidaz...)
Affinity DataIC50: 0.140nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2020
Entry Details
US Patent

LigandPNGBDBM279101(5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1-methylimidaz...)
Affinity DataIC50: 0.140nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
US Patent

LigandPNGBDBM168126(US9073936, 1 | US9598426, 1)
Affinity DataKi:  0.200nMAssay Description:Assay: The following phosphodiesterase enzymes may be used: 3′,5′-cyclic-nucleotide-specific bovine brain phosphodiesterase (Sigma, St. L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

LigandPNGBDBM168126(US9073936, 1 | US9598426, 1)
Affinity DataKi:  0.200nM ΔG°:  -56.3kJ/molepH: 7.5 T: 2°CAssay Description:Materials: All chemicals are available from Sigma-Aldrich (St. Louis, Mo.) except for IMAP reagents (reaction buffer, binding buffer, FL-GMP and IMAP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2016
Entry Details
US Patent

LigandPNGBDBM528351(US11180503, Example 9 | 9-([1,1'- Bi(cyclopropan)]...)
Affinity DataIC50: 0.214nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent

LigandPNGBDBM279111(1-isopropyl-3-methyl-N-[(1-methylimidazol-4-yl)met...)
Affinity DataIC50: 0.260nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

LigandPNGBDBM279111(1-isopropyl-3-methyl-N-[(1-methylimidazol-4-yl)met...)
Affinity DataIC50: 0.260nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
US Patent

LigandPNGBDBM501512(1-isopropyl-3-methyl-N-[(1-methylimidazol-4- yl)me...)
Affinity DataIC50: 0.260nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM279111(1-isopropyl-3-methyl-N-[(1-methylimidazol-4-yl)met...)
Affinity DataIC50: 0.260nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
US Patent

LigandPNGBDBM279111(1-isopropyl-3-methyl-N-[(1-methylimidazol-4-yl)met...)
Affinity DataIC50: 0.260nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
US Patent

LigandPNGBDBM279111(1-isopropyl-3-methyl-N-[(1-methylimidazol-4-yl)met...)
Affinity DataIC50: 0.260nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2020
Entry Details
US Patent

LigandPNGBDBM279111(1-isopropyl-3-methyl-N-[(1-methylimidazol-4-yl)met...)
Affinity DataIC50: 0.260nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
US Patent

LigandPNGBDBM528352(US11180503, Example 10 | 9-([1,1'-bi(cyclopropan)]...)
Affinity DataIC50: 0.260nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent

LigandPNGBDBM168128(US9073936, 3 | US9598426, 3)
Affinity DataKi:  0.300nMAssay Description:Assay: The following phosphodiesterase enzymes may be used: 3′,5′-cyclic-nucleotide-specific bovine brain phosphodiesterase (Sigma, St. L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

LigandPNGBDBM168128(US9073936, 3 | US9598426, 3)
Affinity DataKi:  0.300nM ΔG°:  -55.3kJ/molepH: 7.5 T: 2°CAssay Description:Materials: All chemicals are available from Sigma-Aldrich (St. Louis, Mo.) except for IMAP reagents (reaction buffer, binding buffer, FL-GMP and IMAP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2016
Entry Details
US Patent

LigandPNGBDBM528349(US11180503, Example 7 | 9-([1,1'- Bi(cyclopropan)]...)
Affinity DataIC50: 0.343nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent

LigandPNGBDBM279100(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50: 0.350nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

LigandPNGBDBM279100(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50: 0.350nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
US Patent

LigandPNGBDBM501501(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1- methylpropyl...)
Affinity DataIC50: 0.350nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM279100(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50: 0.350nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
US Patent

LigandPNGBDBM279100(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50: 0.350nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
US Patent

LigandPNGBDBM580556(US11491140, Example 131 | 5-(2-ethoxy-3-pyridyl)-3...)
Affinity DataIC50: 0.350nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
US Patent

LigandPNGBDBM279100(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50: 0.350nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2020
Entry Details
US Patent

LigandPNGBDBM528331(US11180503, Example 1 | 9-([1,1'-bi(cyclopropan)]-...)
Affinity DataIC50: 0.366nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent

LigandPNGBDBM279017(5-(2-ethoxypyridin-3-yl)-1-isopropyl-3-methyl-N-((...)
Affinity DataIC50: 0.390nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
US Patent

LigandPNGBDBM279024(N-[(1,5-dimethylpyrazol-3-yl)methyl]-5-(2-ethoxy-3...)
Affinity DataIC50: 0.390nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
US Patent

LigandPNGBDBM279024(N-[(1,5-dimethylpyrazol-3-yl)methyl]-5-(2-ethoxy-3...)
Affinity DataIC50: 0.390nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2020
Entry Details
US Patent

LigandPNGBDBM279024(N-[(1,5-dimethylpyrazol-3-yl)methyl]-5-(2-ethoxy-3...)
Affinity DataIC50: 0.390nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
US Patent

LigandPNGBDBM279024(N-[(1,5-dimethylpyrazol-3-yl)methyl]-5-(2-ethoxy-3...)
Affinity DataIC50: 0.390nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM279024(N-[(1,5-dimethylpyrazol-3-yl)methyl]-5-(2-ethoxy-3...)
Affinity DataIC50: 0.390nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

LigandPNGBDBM279024(N-[(1,5-dimethylpyrazol-3-yl)methyl]-5-(2-ethoxy-3...)
Affinity DataIC50: 0.390nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
US Patent

LigandPNGBDBM168129(US9073936, 4 | US9598426, 4)
Affinity DataKi:  0.400nM ΔG°:  -54.5kJ/molepH: 7.5 T: 2°CAssay Description:Materials: All chemicals are available from Sigma-Aldrich (St. Louis, Mo.) except for IMAP reagents (reaction buffer, binding buffer, FL-GMP and IMAP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2016
Entry Details
US Patent

LigandPNGBDBM279114(1-isopropyl-3-methyl-N-[(1-methyl-1,2,4-triazol-3-...)
Affinity DataIC50: 0.410nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2020
Entry Details
US Patent

LigandPNGBDBM279114(1-isopropyl-3-methyl-N-[(1-methyl-1,2,4-triazol-3-...)
Affinity DataIC50: 0.410nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
US Patent

LigandPNGBDBM279114(1-isopropyl-3-methyl-N-[(1-methyl-1,2,4-triazol-3-...)
Affinity DataIC50: 0.410nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
US Patent

LigandPNGBDBM279114(1-isopropyl-3-methyl-N-[(1-methyl-1,2,4-triazol-3-...)
Affinity DataIC50: 0.410nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

LigandPNGBDBM279114(1-isopropyl-3-methyl-N-[(1-methyl-1,2,4-triazol-3-...)
Affinity DataIC50: 0.410nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
US Patent

LigandPNGBDBM279114(1-isopropyl-3-methyl-N-[(1-methyl-1,2,4-triazol-3-...)
Affinity DataIC50: 0.410nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM279114(1-isopropyl-3-methyl-N-[(1-methyl-1,2,4-triazol-3-...)
Affinity DataIC50: 0.410nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
US Patent

LigandPNGBDBM278972(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-...)
Affinity DataIC50: 0.460nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

LigandPNGBDBM278972(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-...)
Affinity DataIC50: 0.460nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
US Patent

LigandPNGBDBM278972(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-...)
Affinity DataIC50: 0.460nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM278972(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-...)
Affinity DataIC50: 0.460nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
US Patent

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