Compile Data Set for Download or QSAR
maximum 50k data
Report error Found 130 for UniProtKB: Q92800
TargetHistone-lysine N-methyltransferase EZH1(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50246967(CHEMBL4080228 | US10570121, Example 81)
Affinity DataKi:  70nMAssay Description:Binding affinity to EZH1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed

LigandPNGBDBM50287072(CHEMBL4159112 | US10759787, Example 12 | US1105981...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50287050(CHEMBL4161265)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone-lysine N-methyltransferase EZH1(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM588052((2R)-7-chloro-2-[trans-4-(dimethylamino)cyclohexyl...)
Affinity DataIC50:  0.440nMAssay Description:Inhibition of EZH1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPurchase
In DepthDetails ArticlePubMed

TargetHistone-lysine N-methyltransferase EZH1(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50594132(CHEMBL5197386)
Affinity DataIC50:  0.470nMAssay Description:Inhibition of EZH1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

LigandPNGBDBM50287052(CHEMBL4165937)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50287284(CHEMBL4160111)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50287068(CHEMBL4172576 | US10759787, Example 30 | US1105981...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50287071(CHEMBL4164687 | US10759787, Example 29 | US1105981...)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50287125(CHEMBL4170327 | US10759787, Example 19 | US1105981...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50287049(CHEMBL4162316)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50287283(CHEMBL4177454)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM172038(BDBM190183 | US10155002, Compound 44 | US10647700,...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50287054(CHEMBL4174176)
Affinity DataIC50:  4nMAssay Description:Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50287048(CHEMBL4162499 | US10759787, Example 9 | US11059811...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50287277(CHEMBL4170753 | US10759787, Example 18 | US1105981...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50287058(CHEMBL4169191)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50287276(CHEMBL4162406)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50287051(CHEMBL4169368)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50287056(CHEMBL4169598 | US10759787, Example 20 | US1105981...)
Affinity DataIC50:  5.90nMAssay Description:Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50287306(CHEMBL4167587)
Affinity DataIC50:  6nMAssay Description:Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50287119(CHEMBL4169762)
Affinity DataIC50:  6.10nMAssay Description:Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50287053(CHEMBL4161444 | US10759787, Example 1 | US11059811...)
Affinity DataIC50:  6.40nMAssay Description:Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50287047(CHEMBL4176373)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone-lysine N-methyltransferase EZH1(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50594116(CHEMBL5185991)
Affinity DataIC50:  7nMAssay Description:Inhibition of EZH1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

LigandPNGBDBM50287307(CHEMBL4176554 | US10759787, Example 6 | US11059811...)
Affinity DataIC50:  7.80nMAssay Description:Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone-lysine N-methyltransferase EZH1(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM588043((R)-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-y...)
Affinity DataIC50:  8.31nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent


TargetHistone-lysine N-methyltransferase EZH1(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM588052((2R)-7-chloro-2-[trans-4-(dimethylamino)cyclohexyl...)
Affinity DataIC50:  8.40nMAssay Description:Inhibition of human EZH1 by radiometric analysisMore data for this Ligand-Target Pair
Ligand InfoPurchase
In DepthDetails ArticlePubMed

TargetHistone-lysine N-methyltransferase EZH1(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM588042(6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-yl)me...)
Affinity DataIC50:  12nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent


TargetHistone-lysine N-methyltransferase EZH1(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM588044((R)-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-y...)
Affinity DataIC50:  12nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent


TargetHistone-lysine N-methyltransferase EZH1(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50075054(CHEMBL3414574)
Affinity DataIC50:  13nMAssay Description:Inhibition of EZH1 (unknown origin) using dimethylated H3K27 as substrate in presence of SAM by biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone-lysine N-methyltransferase EZH1(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM588047((R)-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-y...)
Affinity DataIC50:  14nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent


TargetHistone-lysine N-methyltransferase EZH1(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM588031(9-chloro-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridi...)
Affinity DataIC50:  15nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent


TargetHistone-lysine N-methyltransferase EZH1(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM588041(9-bromo-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin...)
Affinity DataIC50:  15nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent


TargetHistone-lysine N-methyltransferase EZH1(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM588032(9-chloro-2-(4- (dimethylamino)bicyclo[2.2.2]octan-...)
Affinity DataIC50:  17nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent


TargetHistone-lysine N-methyltransferase EZH1(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM588050((R)-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-y...)
Affinity DataIC50:  18nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent


LigandPNGBDBM50149895(CHEMBL3770000)
Affinity DataIC50:  20nMAssay Description:Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone-lysine N-methyltransferase EZH1(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM588048((R)-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-y...)
Affinity DataIC50:  20nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent


TargetHistone-lysine N-methyltransferase EZH1(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50590375(CHEMBL5187396)
Affinity DataIC50:  21nMAssay Description:Inhibition of EZH1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetHistone-lysine N-methyltransferase EZH1(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM588046((R)-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-y...)
Affinity DataIC50:  22nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent


TargetHistone-lysine N-methyltransferase EZH1(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM588049((R)-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-y...)
Affinity DataIC50:  22nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent


TargetHistone-lysine N-methyltransferase EZH1(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM588052((2R)-7-chloro-2-[trans-4-(dimethylamino)cyclohexyl...)
Affinity DataIC50:  23nMAssay Description:Inhibition of wildtype EZH1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPurchase
In DepthDetails ArticlePubMed

TargetHistone-lysine N-methyltransferase EZH1(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50590376(CHEMBL5193486)
Affinity DataIC50:  23nMAssay Description:Inhibition of EZH1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetHistone-lysine N-methyltransferase EZH1(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM588052((2R)-7-chloro-2-[trans-4-(dimethylamino)cyclohexyl...)
Affinity DataIC50:  31.5nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand InfoPurchase
In DepthDetails US Patent


TargetHistone-lysine N-methyltransferase EZH1(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM588045((R)-6-((4,6-dimethyl-2-oxo-1,2- dihydropyridin-3-y...)
Affinity DataIC50:  32nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent


TargetHistone-lysine N-methyltransferase EZH1(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50075051(CHEMBL3360855 | EPZ005687 | US10273223, Compound C...)
Affinity DataIC50:  45nMAssay Description:Inhibition of EZH1 in PRC2 complex (unknown origin) using biotinylated peptide as substrate in presence of S-adenosylmethionineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone-lysine N-methyltransferase EZH1(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50594130(CHEMBL5196227)
Affinity DataIC50:  45nMAssay Description:Inhibition of EZH1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetHistone-lysine N-methyltransferase EZH1(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50075071(CHEMBL3414619)
Affinity DataIC50:  45nMAssay Description:Inhibition of human recombinant full length EZH1 measured after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone-lysine N-methyltransferase EZH1(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50075071(CHEMBL3414619)
Affinity DataIC50:  45nMAssay Description:Inhibition of wildtype EZH1 expressed in human MCF-10A cells assessed as reduction in H3K27me3 level incubated for 1 hr by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM225230(EED226 | US11013745, Compound EED226)
Affinity DataIC50:  50nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

Displayed 1 to 50 (of 130 total ) | Next | Last >>
Jump to: