BindingDB PrimarySearch_ki

Report error Found 332 of affinity data for UniProtKB/TrEMBL: Q9C0B1

Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM589235(US11555009, Compound 15 | US11555009, Compound 29)

IC50: 60nMAssay Description:Inhibition of FTO (unknown origin) mediated m6A methylation by HPLC analysisMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

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3D Structure (crystal)

Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM589235(US11555009, Compound 15 | US11555009, Compound 29)

IC50: 60nMAssay Description:Inhibition of FTO (unknown origin) demethylation activity using m6A7-Broccoli RNA as substrate incubated for 3 mins under shaking condition and measu...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

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3D Structure (crystal)

Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM589235(US11555009, Compound 15 | US11555009, Compound 29)

IC50: 60nMAssay Description:The present invention provides a novel class of demethylase FTO inhibitors which inhibit FTO protein activity at very low concentration (typically IC...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

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PDB

3D Structure (crystal)

Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50599021(CHEMBL5195767)

IC50: 70nMAssay Description:Inhibition of recombinant FTO (unknown origin) using m6A Broccoli as substrate incubated for 2 hrsMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM624871(US20230322715, Compound TR-FTO-35)

IC50: 70nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details US Patent

Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50606681(CHEMBL5219846)

IC50: 80nMAssay Description:Inhibition of recombinant full length N-terminal hexahistidine-tagged human FTO expressed in Escherichia coli BL21 (DE3) incubated for 10 mins using ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

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3D Structure (crystal)

Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50596052(CHEMBL5196484)

IC50: 87nMAssay Description:Inhibition of FTO (unknown origin) demethylation activity by HPLC assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

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Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50599012(CHEMBL5200892 | US20230322715, Compound TR-FTO-11)

IC50: 110nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details US Patent

Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50599012(CHEMBL5200892 | US20230322715, Compound TR-FTO-11)

IC50: 110nMAssay Description:Inhibition of recombinant FTO (unknown origin) using m6A Broccoli as substrate incubated for 2 hrsMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50624049(CHEMBL5410889)

IC50: 120nMAssay Description:Inhibition of FTO (unknown origin) using (5'-AUUGUCA(M6A)CAGCAGC-3') as substrate incubated for 2 hrs by dot-blot assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50599025(CHEMBL5207866 | US20230322715, Compound TR-FTO-40)

IC50: 160nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details US Patent

Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50599025(CHEMBL5207866 | US20230322715, Compound TR-FTO-40)

IC50: 160nMAssay Description:Inhibition of recombinant FTO (unknown origin) using m6A Broccoli as substrate incubated for 2 hrsMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50594333(CHEMBL5174419)

IC50: 200nMAssay Description:Inhibition of N-terminal His-tagged human FTO expressed in Escherichia coli BL21(DE3) by PAGE based assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM624873(US20230322715, Compound TR-FTO-38)

IC50: 270nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details US Patent

Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50599023(CHEMBL5194680)

IC50: 270nMAssay Description:Inhibition of recombinant FTO (unknown origin) using m6A Broccoli as substrate incubated for 2 hrsMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50606682(CHEMBL5220094)

IC50: 330nMAssay Description:Inhibition of recombinant full length N-terminal hexahistidine-tagged human FTO expressed in Escherichia coli BL21 (DE3) incubated for 10 mins using ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50485565(CHEMBL465179)

IC50: 340nMAssay Description:Inhibition of FTO (unknown origin) demethylation activity using m6A7-Broccoli RNA as substrate incubated for 3 mins under shaking condition and measu...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

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Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50599019(CHEMBL5207797 | US20230322715, Compound TR-FTO-30)

IC50: 350nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details US Patent

Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50599011(CHEMBL5204291 | US20230322715, Compound TR-FTO-09)

IC50: 350nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details US Patent

Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50599019(CHEMBL5207797 | US20230322715, Compound TR-FTO-30)

IC50: 350nMAssay Description:Inhibition of recombinant FTO (unknown origin) using m6A Broccoli as substrate incubated for 2 hrsMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50599011(CHEMBL5204291 | US20230322715, Compound TR-FTO-09)

IC50: 350nMAssay Description:Inhibition of recombinant FTO (unknown origin) using m6A Broccoli as substrate incubated for 2 hrsMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM589235(US11555009, Compound 15 | US11555009, Compound 29)

IC50: 400nMAssay Description:Inhibition of FTO (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

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3D Structure (crystal)

Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM589238(US11555009, Compound 26)

IC50: 400nMAssay Description:The present invention provides a novel class of demethylase FTO inhibitors which inhibit FTO protein activity at very low concentration (typically IC...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details US Patent

Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM589235(US11555009, Compound 15 | US11555009, Compound 29)

IC50: 400nMAssay Description:Inhibition of N-terminal His-tagged human FTO expressed in Escherichia coli BL21(DE3) by PAGE based assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

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3D Structure (crystal)

Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50606686(CHEMBL5219336)

IC50: 430nMAssay Description:Inhibition of recombinant full length N-terminal hexahistidine-tagged human FTO expressed in Escherichia coli BL21 (DE3) incubated for 10 mins using ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50599013(CHEMBL5199622 | US20230322715, Compound TR-FTO-44)

IC50: 440nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details US Patent

Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50599029(CHEMBL5203668)

IC50: 440nMAssay Description:Inhibition of recombinant FTO (unknown origin) using m6A Broccoli as substrate incubated for 2 hrsMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM85848(CAS_172307 | Fiduxosin | NSC_172307)

IC50: 490nMAssay Description:Inhibition of FTO (unknown origin) demethylation activity using m6A7-Broccoli RNA as substrate incubated for 3 mins under shaking condition and measu...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

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Details Article PubMed

Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM589236(US11555009, Compound 17)

IC50: 500nMAssay Description:Inhibition of N-terminal His-tagged human FTO expressed in Escherichia coli BL21(DE3) by PAGE based assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50417150(CHEMBL4461072)

IC50: 500nMAssay Description:Inhibition of FTO (unknown origin) demethylation activityMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

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Details Article PubMed

Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50596051(CHEMBL5183243)

IC50: 570nMAssay Description:Inhibition of FTO (unknown origin) demethylation activity by HPLC assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

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Details Article PubMed

Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50594336(CHEMBL5176527)

IC50: 600nMAssay Description:Inhibition of N-terminal His-tagged human FTO expressed in Escherichia coli BL21(DE3) by PAGE based assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50599018(CHEMBL5186890 | US20230322715, Compound TR-FTO-27)

IC50: 670nMAssay Description:Inhibition of recombinant FTO (unknown origin) using m6A Broccoli as substrate incubated for 2 hrsMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50599018(CHEMBL5186890 | US20230322715, Compound TR-FTO-27)

IC50: 670nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details US Patent

Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM477000(US11555009, Compound 1)

IC50: 700nMAssay Description:The present invention provides a novel class of demethylase FTO inhibitors which inhibit FTO protein activity at very low concentration (typically IC...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details US Patent

Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50417861(CHEMBL4435048)

IC50: 700nMAssay Description:Inhibition of FTO (unknown origin) demethylation activityMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

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3D Structure (crystal)

Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50594337(CHEMBL5176730)

IC50: 700nMAssay Description:Inhibition of FTO (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50594337(CHEMBL5176730)

IC50: 700nMAssay Description:Inhibition of N-terminal His-tagged human FTO expressed in Escherichia coli BL21(DE3) by PAGE based assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50417859(CHEMBL5268705)

IC50: 750nMAssay Description:Inhibition of FTO (unknown origin) demethylation activityMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

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Details Article PubMed

Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50624048(CHEMBL5397077)

IC50: 800nMAssay Description:Inhibition of FTO (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50606684(CHEMBL5220148)

IC50: 800nMAssay Description:Inhibition of recombinant full length N-terminal hexahistidine-tagged human FTO expressed in Escherichia coli BL21 (DE3) incubated for 10 mins using ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50599022(CHEMBL5181285 | US20230322715, Compound TR-FTO-37)

IC50: 810nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details US Patent

Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50599022(CHEMBL5181285 | US20230322715, Compound TR-FTO-37)

IC50: 810nMAssay Description:Inhibition of recombinant FTO (unknown origin) using m6A Broccoli as substrate incubated for 2 hrsMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50596053(CHEMBL5173876)

IC50: 810nMAssay Description:Inhibition of human full length FTO expressed in Escherichia coli BL21 (DE3) Rosetta T1R cells using 3-methylthymidine as substrate incubated for 1 h...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed PDB

3D Structure (crystal)

Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50599013(CHEMBL5199622 | US20230322715, Compound TR-FTO-44)

IC50: 830nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details US Patent

Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50599013(CHEMBL5199622 | US20230322715, Compound TR-FTO-44)

IC50: 830nMAssay Description:Inhibition of recombinant FTO (unknown origin) using m6A Broccoli as substrate incubated for 2 hrsMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50017226((R)-2-Amino-7-phosphono-heptanoic acid | 2-Amino-7...)

IC50: 850nMAssay Description:Inhibition of FTO (unknown origin) demethylation activity using m6A7-Broccoli RNA as substrate incubated for 3 mins under shaking condition and measu...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

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Details Article PubMed

Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50599015(CHEMBL5177222 | US20230322715, Compound TR-FTO-14)

IC50: 870nMAssay Description:Inhibition of recombinant FTO (unknown origin) using m6A Broccoli as substrate incubated for 2 hrsMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50599015(CHEMBL5177222 | US20230322715, Compound TR-FTO-14)

IC50: 870nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details US Patent

Alpha-ketoglutarate-dependent dioxygenase FTO(Human)
China Pharmaceutical University

Curated by ChEMBL

PNG

BDBM50599030(CHEMBL5182180 | US20230322715, Compound TR-FTO-45)

IC50: 900nMAssay Description:Inhibition of recombinant FTO (unknown origin) using m6A Broccoli as substrate incubated for 2 hrsMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Displayed 1 to 50 (of 332 total ) | Next | Last >>

Filter my 332 hits

Targets 2▿
- Alpha-ketoglutarate-dependent dioxygenase FTO 331
- Alpha-ketoglutarate-dependent dioxygenase FTO [31-505] 1
Publications 15▿
- J Med Chem 64: 16974-17003 (2021) 83
- US Patent US20230322715 (2023) 61
- J Med Chem 56: 3680-8 (2013) 33
- J Med Chem 64: 16609-16625 (2021) 31
- J Med Chem 65: 10920-10937 (2022) 30
- J Med Chem 66: 15944-15959 (2023) 20
- J Med Chem 65: 10638-10654 (2022) 19
- US Patent US11555009 (2023) 19
- J Med Chem 66: 9731-9752 (2023) 15
- Eur J Med Chem 196: (2020) 8
- ACS Med Chem Lett 14: 1551-1557 (2023) 4
- J Med Chem 64: 15810-15824 (2021) 4
- Eur J Med Chem 238: (2022) 2
- J Med Chem 58: 7341-8 (2015) 2
- Biochemistry 55: 1516-22 (2016) 1
Institutions 13▿
- University College London 83
- University of Oxford 64
- The Regents of The University of California 61
- University of California San Diego 30
- China Pharmaceutical University 28
- Chinese Academy of Sciences 19
- Shanghai Institute of Material Medica, Chinese Academy of Sciences 19
- University of Chinese Academy of Sciences 15
- Nanjing Normal University 4
- Kyoto Prefectural University of Medicine 4
- Nankai University 2
- Zhengzhou University 2
- Basic Medical College of Zhengzhou University 1
Affinity: 28 to 1.0E+6 nM▿
- IC50 326
- Kd 6
- Affinity ≤ nM
Xtal structures: 20
Docked structures: 0
Catalog Cmpds: 64