Compile Data Set for Download or QSAR
Report error Found 565 of affinity data for UniProtKB/TrEMBL: Q9C0B1
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50596052BDBM50596052(CHEMBL5196484)
Affinity DataKd:  28nMAssay Description:Binding affinity to FTO (unknown origin) assessed as dissociation constant at 180 uM by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665050BDBM50665050(CHEMBL6170540)
Affinity DataIC50: 31nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 589235BDBM589235(US11555009, Compound 15 | US11555009, Compound 29)
Affinity DataIC50: 60nMAssay Description:Inhibition of FTO (unknown origin) mediated m6A methylation by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 589235BDBM589235(US11555009, Compound 15 | US11555009, Compound 29)
Affinity DataIC50: 60nMAssay Description:Inhibition of FTO (unknown origin) demethylation activity using m6A7-Broccoli RNA as substrate incubated for 3 mins under shaking condition and measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 589235BDBM589235(US11555009, Compound 15 | US11555009, Compound 29)
Affinity DataIC50: 60nMAssay Description:The present invention provides a novel class of demethylase FTO inhibitors which inhibit FTO protein activity at very low concentration (typically IC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2023
Entry Details
US Patent

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791092BDBM791092((Z)-3-(3-chloro-5-cyano-4- hydroxyphenyl)-2-cyano-...)
Affinity DataIC50: 60nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/17/2026
Entry Details US Patent

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 589235BDBM589235(US11555009, Compound 15 | US11555009, Compound 29)
Affinity DataIC50: 60nMAssay Description:Inhibition of N-terminal FTO (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791104BDBM791104((Z)-2-cyano-3-(3,5-dichloro-4- hydroxyphenyl)-N-(2...)
Affinity DataIC50: 60nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/17/2026
Entry Details US Patent

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50599021BDBM50599021(CHEMBL5195767)
Affinity DataIC50: 70nMAssay Description:Inhibition of recombinant FTO (unknown origin) using m6A Broccoli as substrate incubated for 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 624871BDBM624871(US20230322715, Compound TR-FTO-35)
Affinity DataIC50: 70nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791105BDBM791105((Z)-2-cyano-N-(5-cyano-2-fluorobenzyl)- 3-(3,5-dic...)
Affinity DataIC50: 70nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/17/2026
Entry Details US Patent

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791125BDBM791125((Z)-N-(2-(2-chlorophenoxy)ethyl)-2- cyano-3-(3-cya...)
Affinity DataIC50: 80nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/17/2026
Entry Details US Patent

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50606681BDBM50606681(CHEMBL5219846)
Affinity DataIC50: 80nMAssay Description:Inhibition of recombinant full length N-terminal hexahistidine-tagged human FTO expressed in Escherichia coli BL21 (DE3) incubated for 10 mins using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791097BDBM791097((Z)-N-(5-chloro-2-fluorobenzyl)-2-cyano- 3-(3-cyan...)
Affinity DataIC50: 80nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/17/2026
Entry Details US Patent

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791131BDBM791131(ethyl (Z)-2-cyano-3-hydroxy-3-(4-hydroxy-3-methoxy...)
Affinity DataIC50: 80nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/17/2026
Entry Details US Patent

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50596052BDBM50596052(CHEMBL5196484)
Affinity DataIC50: 87nMAssay Description:Inhibition of FTO (unknown origin) demethylation activity by HPLC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791126BDBM791126((Z)-2-cyano-3-(3-cyano-5-fluoro-4- hydroxyphenyl)-...)
Affinity DataIC50: 90nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/17/2026
Entry Details US Patent

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791085BDBM791085((Z)-2-cyano-3-(3-cyano-5-fluoro-4- hydroxyphenyl)-...)
Affinity DataIC50: 90nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/17/2026
Entry Details US Patent

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791090BDBM791090((Z)-2-cyano-3-(3,5-dicyano-4- hydroxyphenyl)-N-(2-...)
Affinity DataIC50: 90nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/17/2026
Entry Details US Patent

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791141BDBM791141((Z)-N-(5-chloro-2-fluorobenzyl)-2-cyano- 3-(3-(dif...)
Affinity DataIC50: 90nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/17/2026
Entry Details US Patent

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791086BDBM791086((Z)-2-cyano-3-(3-cyano-4- hydroxyphenyl)-N-(2-fluo...)
Affinity DataIC50: 110nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/17/2026
Entry Details US Patent

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791094BDBM791094((Z)-N-(5-chloro-2-fluorobenzyl)-2-cyano- 3-(3,5-di...)
Affinity DataIC50: 110nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/17/2026
Entry Details US Patent

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50599012BDBM50599012(CHEMBL5200892 | US20230322715, Compound TR-FTO-11)
Affinity DataIC50: 110nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50599012BDBM50599012(CHEMBL5200892 | US20230322715, Compound TR-FTO-11)
Affinity DataIC50: 110nMAssay Description:Inhibition of recombinant FTO (unknown origin) using m6A Broccoli as substrate incubated for 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791106BDBM791106((Z)-2-cyano-3-(3-cyano-4- hydroxyphenyl)-N-(2-fluo...)
Affinity DataIC50: 110nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/17/2026
Entry Details US Patent

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50624049BDBM50624049(CHEMBL5410889)
Affinity DataIC50: 120nMAssay Description:Inhibition of FTO (unknown origin) using (5'-AUUGUCA(M6A)CAGCAGC-3') as substrate incubated for 2 hrs by dot-blot assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791066BDBM791066((Z)-2-cyano-N-(2-fluoro-5- methoxybenzyl)-3-hydrox...)
Affinity DataIC50: 120nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/17/2026
Entry Details US Patent

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791134BDBM791134((Z)-2-(cyclopropanecarbonyl)-3-hydroxy-3-(4-hydrox...)
Affinity DataIC50: 120nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/17/2026
Entry Details US Patent

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791099BDBM791099((Z)-N-(5-chloro-2-fluorobenzyl)-2-cyano- 3-(3-cyan...)
Affinity DataIC50: 130nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/17/2026
Entry Details US Patent

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791095BDBM791095((Z)-N-(5-chloro-2-fluorobenzyl)-3-(3- chloro-5-flu...)
Affinity DataIC50: 130nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/17/2026
Entry Details US Patent

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791091BDBM791091((Z)-2-cyano-3-(3-cyano-4-hydroxy-5- methylphenyl)-...)
Affinity DataIC50: 140nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/17/2026
Entry Details US Patent

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791139BDBM791139((Z)-3-(5-chloro-2-fluoro-4- hydroxyphenyl)-N-(5-ch...)
Affinity DataIC50: 150nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/17/2026
Entry Details US Patent

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791121BDBM791121((Z)-3-(3-chloro-4-hydroxy- 5-nitrophenyl)-2-cyano-...)
Affinity DataIC50: 150nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/17/2026
Entry Details US Patent

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791007BDBM791007((Z)-2-cyano-3-(3,4-dihydroxy-5- nitrophenyl)-3-hyd...)
Affinity DataIC50: 150nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/17/2026
Entry Details US Patent

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791093BDBM791093((Z)-2-cyano-3-(3,5-dichloro-4- hydroxyphenyl)-N-(2...)
Affinity DataIC50: 150nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/17/2026
Entry Details US Patent

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50599025BDBM50599025(CHEMBL5207866 | US20230322715, Compound TR-FTO-40)
Affinity DataIC50: 160nMAssay Description:Inhibition of recombinant FTO (unknown origin) using m6A Broccoli as substrate incubated for 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791065BDBM791065((Z)-N-(5-chloro-2-fluorobenzyl)-2-cyano- 3-hydroxy...)
Affinity DataIC50: 160nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/17/2026
Entry Details US Patent

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791063BDBM791063((Z)-2-cyano-N-(2-fluoro-5- methylbenzyl)-3-hydroxy...)
Affinity DataIC50: 160nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/17/2026
Entry Details US Patent

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50599025BDBM50599025(CHEMBL5207866 | US20230322715, Compound TR-FTO-40)
Affinity DataIC50: 160nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791089BDBM791089((Z)-2-cyano-3-(3-cyano-4-hydroxy-5- methoxyphenyl)...)
Affinity DataIC50: 160nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/17/2026
Entry Details US Patent

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665051BDBM50665051(CHEMBL6177289)
Affinity DataIC50: 180nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791098BDBM791098((Z)-N-(5-chloro-2-fluorobenzyl)-2-cyano- 3-(3-cyan...)
Affinity DataIC50: 200nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/17/2026
Entry Details US Patent

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594333BDBM50594333(CHEMBL5174419)
Affinity DataIC50: 200nMAssay Description:Inhibition of N-terminal His-tagged human FTO expressed in Escherichia coli BL21(DE3) by PAGE based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791123BDBM791123((Z)-3-(3-chloro-5-cyano-4- hydroxyphenyl)-2-cyano-...)
Affinity DataIC50: 210nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/17/2026
Entry Details US Patent

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791096BDBM791096((Z)-N-(5-chloro-2-fluorobenzyl)-2-cyano- 3-(3,5-di...)
Affinity DataIC50: 210nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/17/2026
Entry Details US Patent

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791144BDBM791144((Z)-N-(5-bromo-2-fluorobenzyl)-2- cyano-3-hydroxy-...)
Affinity DataIC50: 220nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/17/2026
Entry Details US Patent

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791100BDBM791100((Z)-N-(5-chloro-2-fluorobenzyl)-2-cyano- 3-(3-cyan...)
Affinity DataIC50: 230nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/17/2026
Entry Details US Patent

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791102BDBM791102((Z)-N-(5-chloro-2-fluorobenzyl)-2-cyano- 3-hydroxy...)
Affinity DataIC50: 250nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/17/2026
Entry Details US Patent

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791122BDBM791122((Z)-2-cyano-3-(3-cyano-4- hydroxyphenyl)-3-hydroxy...)
Affinity DataIC50: 250nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/17/2026
Entry Details US Patent

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791119BDBM791119((Z)-2-cyano-3-(3-fluoro-4-hydroxy-5- nitrophenyl)-...)
Affinity DataIC50: 250nMAssay Description:TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/17/2026
Entry Details US Patent

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