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Report error Found 352 of affinity data for UniProtKB/TrEMBL: Q9C0B1
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50596052BDBM50596052(CHEMBL5196484)
Affinity DataKd:  28nMAssay Description:Binding affinity to FTO (unknown origin) assessed as dissociation constant at 180 uM by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 589235BDBM589235(US11555009, Compound 15 | US11555009, Compound 29)
Affinity DataIC50: 60nMAssay Description:Inhibition of FTO (unknown origin) mediated m6A methylation by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 589235BDBM589235(US11555009, Compound 15 | US11555009, Compound 29)
Affinity DataIC50: 60nMAssay Description:Inhibition of FTO (unknown origin) demethylation activity using m6A7-Broccoli RNA as substrate incubated for 3 mins under shaking condition and measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 589235BDBM589235(US11555009, Compound 15 | US11555009, Compound 29)
Affinity DataIC50: 60nMAssay Description:The present invention provides a novel class of demethylase FTO inhibitors which inhibit FTO protein activity at very low concentration (typically IC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2023
Entry Details
US Patent

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 589235BDBM589235(US11555009, Compound 15 | US11555009, Compound 29)
Affinity DataIC50: 60nMAssay Description:Inhibition of N-terminal FTO (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50599021BDBM50599021(CHEMBL5195767)
Affinity DataIC50: 70nMAssay Description:Inhibition of recombinant FTO (unknown origin) using m6A Broccoli as substrate incubated for 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 624871BDBM624871(US20230322715, Compound TR-FTO-35)
Affinity DataIC50: 70nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50606681BDBM50606681(CHEMBL5219846)
Affinity DataIC50: 80nMAssay Description:Inhibition of recombinant full length N-terminal hexahistidine-tagged human FTO expressed in Escherichia coli BL21 (DE3) incubated for 10 mins using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50596052BDBM50596052(CHEMBL5196484)
Affinity DataIC50: 87nMAssay Description:Inhibition of FTO (unknown origin) demethylation activity by HPLC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50599012BDBM50599012(CHEMBL5200892 | US20230322715, Compound TR-FTO-11)
Affinity DataIC50: 110nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50599012BDBM50599012(CHEMBL5200892 | US20230322715, Compound TR-FTO-11)
Affinity DataIC50: 110nMAssay Description:Inhibition of recombinant FTO (unknown origin) using m6A Broccoli as substrate incubated for 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50624049BDBM50624049(CHEMBL5410889)
Affinity DataIC50: 120nMAssay Description:Inhibition of FTO (unknown origin) using (5'-AUUGUCA(M6A)CAGCAGC-3') as substrate incubated for 2 hrs by dot-blot assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50599025BDBM50599025(CHEMBL5207866 | US20230322715, Compound TR-FTO-40)
Affinity DataIC50: 160nMAssay Description:Inhibition of recombinant FTO (unknown origin) using m6A Broccoli as substrate incubated for 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50599025BDBM50599025(CHEMBL5207866 | US20230322715, Compound TR-FTO-40)
Affinity DataIC50: 160nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594333BDBM50594333(CHEMBL5174419)
Affinity DataIC50: 200nMAssay Description:Inhibition of N-terminal His-tagged human FTO expressed in Escherichia coli BL21(DE3) by PAGE based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 624873BDBM624873(US20230322715, Compound TR-FTO-38)
Affinity DataIC50: 270nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50599023BDBM50599023(CHEMBL5194680)
Affinity DataIC50: 270nMAssay Description:Inhibition of recombinant FTO (unknown origin) using m6A Broccoli as substrate incubated for 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50606682BDBM50606682(CHEMBL5220094)
Affinity DataIC50: 330nMAssay Description:Inhibition of recombinant full length N-terminal hexahistidine-tagged human FTO expressed in Escherichia coli BL21 (DE3) incubated for 10 mins using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50606681BDBM50606681(CHEMBL5219846)
Affinity DataKd:  340nMAssay Description:Binding affinity to recombinant full length N-terminal hexahistidine-tagged human FTO expressed in Escherichia coli BL21 by competition-based NMR bin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50485565BDBM50485565(CHEMBL465179)
Affinity DataIC50: 340nMAssay Description:Inhibition of FTO (unknown origin) demethylation activity using m6A7-Broccoli RNA as substrate incubated for 3 mins under shaking condition and measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50599019BDBM50599019(CHEMBL5207797 | US20230322715, Compound TR-FTO-30)
Affinity DataIC50: 350nMAssay Description:Inhibition of recombinant FTO (unknown origin) using m6A Broccoli as substrate incubated for 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50599011BDBM50599011(CHEMBL5204291 | US20230322715, Compound TR-FTO-09)
Affinity DataIC50: 350nMAssay Description:Inhibition of recombinant FTO (unknown origin) using m6A Broccoli as substrate incubated for 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50599019BDBM50599019(CHEMBL5207797 | US20230322715, Compound TR-FTO-30)
Affinity DataIC50: 350nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50599011BDBM50599011(CHEMBL5204291 | US20230322715, Compound TR-FTO-09)
Affinity DataIC50: 350nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 589238BDBM589238(US11555009, Compound 26)
Affinity DataIC50: 400nMAssay Description:The present invention provides a novel class of demethylase FTO inhibitors which inhibit FTO protein activity at very low concentration (typically IC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2023
Entry Details
US Patent

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 589235BDBM589235(US11555009, Compound 15 | US11555009, Compound 29)
Affinity DataIC50: 400nMAssay Description:Inhibition of FTO (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 589235BDBM589235(US11555009, Compound 15 | US11555009, Compound 29)
Affinity DataIC50: 400nMAssay Description:Inhibition of N-terminal His-tagged human FTO expressed in Escherichia coli BL21(DE3) by PAGE based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 589244BDBM589244(US11555009, Compound 32)
Affinity DataIC50: 400nMAssay Description:Inhibition of FTO (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50606686BDBM50606686(CHEMBL5219336)
Affinity DataIC50: 430nMAssay Description:Inhibition of recombinant full length N-terminal hexahistidine-tagged human FTO expressed in Escherichia coli BL21 (DE3) incubated for 10 mins using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50599013BDBM50599013(CHEMBL5199622 | US20230322715, Compound TR-FTO-44)
Affinity DataIC50: 440nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50599029BDBM50599029(CHEMBL5203668)
Affinity DataIC50: 440nMAssay Description:Inhibition of recombinant FTO (unknown origin) using m6A Broccoli as substrate incubated for 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 85848BDBM85848(CAS_172307 | NSC_172307 | Fiduxosin)
Affinity DataIC50: 490nMAssay Description:Inhibition of FTO (unknown origin) demethylation activity using m6A7-Broccoli RNA as substrate incubated for 3 mins under shaking condition and measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50417150BDBM50417150(CHEMBL4461072)
Affinity DataIC50: 500nMAssay Description:Inhibition of FTO (unknown origin) demethylation activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 589236BDBM589236(US11555009, Compound 17)
Affinity DataIC50: 500nMAssay Description:Inhibition of N-terminal His-tagged human FTO expressed in Escherichia coli BL21(DE3) by PAGE based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50596051BDBM50596051(CHEMBL5183243)
Affinity DataIC50: 570nMAssay Description:Inhibition of FTO (unknown origin) demethylation activity by HPLC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594336BDBM50594336(CHEMBL5176527)
Affinity DataIC50: 600nMAssay Description:Inhibition of N-terminal His-tagged human FTO expressed in Escherichia coli BL21(DE3) by PAGE based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50647347BDBM50647347(CHEMBL1253979)
Affinity DataIC50: 640nMAssay Description:Inhibition of FTO (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50599018BDBM50599018(CHEMBL5186890 | US20230322715, Compound TR-FTO-27)
Affinity DataIC50: 670nMAssay Description:Inhibition of recombinant FTO (unknown origin) using m6A Broccoli as substrate incubated for 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50606686BDBM50606686(CHEMBL5219336)
Affinity DataKd:  670nMAssay Description:Binding affinity to recombinant full length N-terminal hexahistidine-tagged human FTO expressed in Escherichia coli BL21 by competition-based NMR bin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50599018BDBM50599018(CHEMBL5186890 | US20230322715, Compound TR-FTO-27)
Affinity DataIC50: 670nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594337BDBM50594337(CHEMBL5176730)
Affinity DataIC50: 700nMAssay Description:Inhibition of N-terminal His-tagged human FTO expressed in Escherichia coli BL21(DE3) by PAGE based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 477000BDBM477000(US11555009, Compound 1)
Affinity DataIC50: 700nMAssay Description:The present invention provides a novel class of demethylase FTO inhibitors which inhibit FTO protein activity at very low concentration (typically IC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2023
Entry Details
US Patent

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50417861BDBM50417861(CHEMBL4435048)
Affinity DataIC50: 700nMAssay Description:Inhibition of FTO (unknown origin) demethylation activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594337BDBM50594337(CHEMBL5176730)
Affinity DataIC50: 700nMAssay Description:Inhibition of FTO (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50417859BDBM50417859(CHEMBL5268705)
Affinity DataIC50: 750nMAssay Description:Inhibition of FTO (unknown origin) demethylation activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50647348BDBM50647348(CHEMBL5597797)
Affinity DataIC50: 780nMAssay Description:Inhibition of FTO (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50624048BDBM50624048(CHEMBL5397077)
Affinity DataIC50: 800nMAssay Description:Inhibition of FTO (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50606684BDBM50606684(CHEMBL5220148)
Affinity DataIC50: 800nMAssay Description:Inhibition of recombinant full length N-terminal hexahistidine-tagged human FTO expressed in Escherichia coli BL21 (DE3) incubated for 10 mins using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50599022BDBM50599022(CHEMBL5181285 | US20230322715, Compound TR-FTO-37)
Affinity DataIC50: 810nMAssay Description:Inhibition of recombinant FTO (unknown origin) using m6A Broccoli as substrate incubated for 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50596053BDBM50596053(CHEMBL5173876)
Affinity DataIC50: 810nMAssay Description:Inhibition of human full length FTO expressed in Escherichia coli BL21 (DE3) Rosetta T1R cells using 3-methylthymidine as substrate incubated for 1 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
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