Compile Data Set for Download or QSAR
Report error Found 1110 of affinity data for UniProtKB/TrEMBL: Q9N1N9
TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM8961(CHEMBL95 | Cognex | cid_1935 | CHEMBL1337960 | 1,2...)
Affinity DataIC50: 0.0244nMAssay Description:Enzyme activity using acetylcholinesterase (AChE) and butyrylcholinesterase (BChE).More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM8977(N-[3-(1,2,3,4-Tetrahydroacridin-9-ylamino)propyl]-...)
Affinity DataKi:  0.110nMAssay Description:Inhibition of enzyme activity was measured over a substrate concentration range of 0.01-30 mM and at least six inhibitor concentrations to determine ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2006
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM8975(CHEMBL179192 | N-[3-(1,2,3,4-Tetrahydroacridin-9-y...)
Affinity DataKi:  0.230nMAssay Description:Inhibition of enzyme activity was measured over a substrate concentration range of 0.01-30 mM and at least six inhibitor concentrations to determine ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2006
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM8971(CHEMBL129108 | N-[8-(1,2,3,4-tetrahydroacridin-9-y...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of enzyme activity was measured over a substrate concentration range of 0.01-30 mM and at least six inhibitor concentrations to determine ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2006
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM86769(Nicotinamide hydrochloride analog, 6b)
Affinity DataIC50: 0.645nMAssay Description:Enzyme activity using acetylcholinesterase (AChE) and butyrylcholinesterase (BChE).More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2012
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM8976(N-Methyl-N-(1,2,3,4-tetrahydroacridin-9-yl)-N-[4-(...)
Affinity DataKi:  0.680nMAssay Description:Inhibition of enzyme activity was measured over a substrate concentration range of 0.01-30 mM and at least six inhibitor concentrations to determine ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2006
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM8986(7-chloro-1,2,3,4-tetrahydroacridin-9-amine | Tacri...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of (BChE) Butyrylcholinesterase of horse serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM8967(prop-2-en-1-ylbis[3-(1,2,3,4-tetrahydroacridin-9-y...)
Affinity DataKi:  0.760nMAssay Description:Inhibition of enzyme activity was measured over a substrate concentration range of 0.01-30 mM and at least six inhibitor concentrations to determine ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2006
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM86771(Nicotinamide hydrochloride analog, 6d)
Affinity DataIC50: 0.811nMAssay Description:Enzyme activity using acetylcholinesterase (AChE) and butyrylcholinesterase (BChE).More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2012
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM8966(ethylbis[3-(1,2,3,4-tetrahydroacridin-9-ylamino)pr...)
Affinity DataKi:  0.940nMAssay Description:Inhibition of enzyme activity was measured over a substrate concentration range of 0.01-30 mM and at least six inhibitor concentrations to determine ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2006
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM9007(7-(1,2,3,4-Tetrahydro-acridin-9-ylamino)-heptanoic...)
Affinity DataIC50: 0.950nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2006
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM227587(3-fluoro-N-[4-(1,2,3,4-tetrahydroacridin-9-ylamino...)
Affinity DataIC50: 1.02nMpH: 7.4 T: 2°CAssay Description:The test was run as described in the following procedure: stock solution of the test compounds was diluted in phosphate buffer pH 7.4 to give final c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2017
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM86770(Nicotinamide hydrochloride analog, 6c)
Affinity DataIC50: 1.13nMAssay Description:Enzyme activity using acetylcholinesterase (AChE) and butyrylcholinesterase (BChE).More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2012
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM50060470(10-azoniatetracyclo[10.2.1.02,11.04,9]pentadeca-2,...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of (BChE) Butyrylcholinesterase of horse serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM227584(2-Fluoro-N-[4-(1,2,3,4-tetrahydroacridin-9-ylamino...)
Affinity DataIC50: 1.39nMpH: 7.4 T: 2°CAssay Description:The test was run as described in the following procedure: stock solution of the test compounds was diluted in phosphate buffer pH 7.4 to give final c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2017
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM9426(N-9-(1,2,3,4-Tetrahydroacridinyl)-1,8-diamino-octa...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of equine BChE by Ellman's assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM86768(Nicotinamide hydrochloride analog, 6a)
Affinity DataIC50: 1.45nMAssay Description:Enzyme activity using acetylcholinesterase (AChE) and butyrylcholinesterase (BChE).More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2012
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM232997((S)-(-)-endo-2-norbornyl-N-n-butylcarbamate)
Affinity DataKi:  2nM ΔG°:  -49.7kJ/molepH: 7.0 T: 2°CAssay Description:BChE inhibitions by the carbamate inhibitors were assayed by the Ellman method [Ellman et al., Biochem. Pharm., 7:88-95]. BChE-catalyzed hydrolysis o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2017
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM9013(6-(1,2,3,4-Tetrahydro-acridin-9-ylamino)-hexanoic ...)
Affinity DataIC50: 2nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2006
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM8963(N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...)
Affinity DataKi:  2nM ΔG°:  -49.7kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition of enzyme activity was measured over a substrate concentration range of 0.01-30 mM and at least six inhibitor concentrations to determine ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2006
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM8963(N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...)
Affinity DataKi:  2nMAssay Description:Inhibition of enzyme activity was measured over a substrate concentration range of 0.01-30 mM and at least six inhibitor concentrations to determine ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2006
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM8964(CHEMBL75274 | N-[8-(1,2,3,4-tetrahydroacridin-9-yl...)
Affinity DataKi:  2nMAssay Description:Inhibition of enzyme activity was measured over a substrate concentration range of 0.01-30 mM and at least six inhibitor concentrations to determine ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2006
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM8969(CHEMBL131410 | N,N-bis[3-(1,2,3,4-tetrahydroacridi...)
Affinity DataKi:  2nMAssay Description:Inhibition of enzyme activity was measured over a substrate concentration range of 0.01-30 mM and at least six inhibitor concentrations to determine ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2006
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM8972(N-(1,2,3,4-Tetrahydroacridin-9-yl)-9-[(1,2,3,4-tet...)
Affinity DataKi:  2.30nMAssay Description:Inhibition of enzyme activity was measured over a substrate concentration range of 0.01-30 mM and at least six inhibitor concentrations to determine ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2006
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM9014(N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-7-(1,2,3,4-te...)
Affinity DataIC50: 2.5nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2006
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM50333767(N1-(1,2,3,4-Tetrahydroacridin-9-yl)-N6-(3,4,5-trim...)
Affinity DataIC50: 2.59nMAssay Description:Inhibition of equine BChE by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM50333763(N1-(3,4-Dimethoxybenzyl)-N6-(1,2,3,4-tetrahydroacr...)
Affinity DataIC50: 2.68nMAssay Description:Inhibition of equine BChE by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM232998(rac-(-)-endo-2-norbornyl carbamate | (R)-(+)-endo-...)
Affinity DataKi:  3nM ΔG°:  -48.6kJ/molepH: 7.0 T: 2°CAssay Description:BChE inhibitions by the carbamate inhibitors were assayed by the Ellman method [Ellman et al., Biochem. Pharm., 7:88-95]. BChE-catalyzed hydrolysis o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2017
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM8968(2-{bis[3-(1,2,3,4-tetrahydroacridin-9-ylamino)prop...)
Affinity DataKi:  3.30nMAssay Description:Inhibition of enzyme activity was measured over a substrate concentration range of 0.01-30 mM and at least six inhibitor concentrations to determine ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2006
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM50333765(N1-(1,2,3,4-Tetrahydroacridin-9-yl)-N8-(3,4,5-trim...)
Affinity DataIC50: 3.38nMAssay Description:Inhibition of equine BChE by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM9018(N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-6-(1,2,3,4-te...)
Affinity DataIC50: 3.5nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2006
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM50333766(N1-(1,2,3,4-Tetrahydroacridin-9-yl)-N7-(3,4,5-trim...)
Affinity DataIC50: 3.55nMAssay Description:Inhibition of equine BChE by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM227586(3-Fluoro-N-[3-(1,2,3,4-tetrahydroacridin-9-ylamino...)
Affinity DataIC50: 3.79nMpH: 7.4 T: 2°CAssay Description:The test was run as described in the following procedure: stock solution of the test compounds was diluted in phosphate buffer pH 7.4 to give final c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2017
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM8974(CHEMBL367067 | N-Methyl-N-(1,2,3,4-tetrahydroacrid...)
Affinity DataKi:  4.20nMAssay Description:Inhibition of enzyme activity was measured over a substrate concentration range of 0.01-30 mM and at least six inhibitor concentrations to determine ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2006
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM50333764(N1-(1,2,3,4-Tetrahydroacridin-9-yl)-N9-(3,4,5-trim...)
Affinity DataIC50: 4.73nMAssay Description:Inhibition of equine BChE by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM227585(3-Fluoro-N-[2-(1,2,3,4-tetrahydroacridin-9-ylamino...)
Affinity DataIC50: 4.76nMpH: 7.4 T: 2°CAssay Description:The test was run as described in the following procedure: stock solution of the test compounds was diluted in phosphate buffer pH 7.4 to give final c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2017
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM50194097(N,N'-bis[2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)...)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of horse serum BChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM232998(rac-(-)-endo-2-norbornyl carbamate | (R)-(+)-endo-...)
Affinity DataKi:  5nM ΔG°:  -47.4kJ/molepH: 7.0 T: 2°CAssay Description:BChE inhibitions by the carbamate inhibitors were assayed by the Ellman method [Ellman et al., Biochem. Pharm., 7:88-95]. BChE-catalyzed hydrolysis o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2017
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM50377432(CHEMBL258927)
Affinity DataIC50: 5nMAssay Description:Inhibition of equine BChE by Ellman's assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM8961(CHEMBL95 | Cognex | cid_1935 | CHEMBL1337960 | 1,2...)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of equine BChE by Ellman's assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM8961(CHEMBL95 | Cognex | cid_1935 | CHEMBL1337960 | 1,2...)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of BuChE from equine serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM50333771(N1-((7-Methoxybenzo[d][1,3]dioxol-5-yl)methyl)-N6-...)
Affinity DataIC50: 5.19nMAssay Description:Inhibition of equine BChE by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM9008(6-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]...)
Affinity DataIC50: 5.20nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2006
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM8961(CHEMBL95 | Cognex | cid_1935 | CHEMBL1337960 | 1,2...)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate after 15 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM8961(CHEMBL95 | Cognex | cid_1935 | CHEMBL1337960 | 1,2...)
Affinity DataIC50: 5.20nMpH: 8.0Assay Description:The inhibitory activity of the enzyme acetylcholinesterase (AChE) was evaluated by the Ellman method (Biochem. Pharmacol. 1961, 7, 88) using an elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2015
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM8961(CHEMBL95 | Cognex | cid_1935 | CHEMBL1337960 | 1,2...)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of (BChE) Butyrylcholinesterase of horse serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article
PDB3D3D Structure (crystal)
TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM50377431(CHEMBL258744)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of equine BChE by Ellman's assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM50333762(N1-(3,4-Dimethoxybenzyl)-N7-(1,2,3,4-tetrahydroacr...)
Affinity DataIC50: 5.51nMAssay Description:Inhibition of equine BChE by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM50333761(N1-(3,4-Dimethoxybenzyl)-N8-(1,2,3,4-tetrahydroacr...)
Affinity DataIC50: 5.57nMAssay Description:Inhibition of equine BChE by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Medical University of Lodz

LigandPNGBDBM50333760(N1-(3,4-Dimethoxybenzyl)-N9-(1,2,3,4-tetrahydroacr...)
Affinity DataIC50: 5.67nMAssay Description:Inhibition of equine BChE by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
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