Found 38 Enz. Inhib. hit(s) with Target = 'Carboxylic ester hydrolase' and Ligand = 'BDBM8961' 
Affinity DataKi: 7nM ΔG°: -46.5kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition of enzyme activity was measured over a substrate concentration range of 0.01-30 mM and at least six inhibitor concentrations to determine ...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 7nMAssay Description:Inhibition of enzyme activity was measured over a substrate concentration range of 0.01-30 mM and at least six inhibitor concentrations to determine ...More data for this Ligand-Target Pair
Affinity DataKi: 25nM ΔG°: -44.1kJ/moleT: 2°CAssay Description:AChE and BChE inhibitory activities were measured in vitro by a modified spectrophotometric method. all the inhibition studies were performed using ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0244nMAssay Description:Enzyme activity using acetylcholinesterase (AChE) and butyrylcholinesterase (BChE).More data for this Ligand-Target Pair
Affinity DataIC50: 5.10nMAssay Description:Inhibition of BuChE from equine serumMore data for this Ligand-Target Pair
Affinity DataIC50: 5.10nMAssay Description:Inhibition of equine BChE by Ellman's assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.20nMpH: 8.0Assay Description:The inhibitory activity of the enzyme acetylcholinesterase (AChE) was evaluated by the Ellman method (Biochem. Pharmacol. 1961, 7, 88) using an elect...More data for this Ligand-Target Pair
Affinity DataIC50: 5.20nMAssay Description:Inhibition of (BChE) Butyrylcholinesterase of horse serumMore data for this Ligand-Target Pair
Affinity DataIC50: 5.20nMAssay Description:Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate after 15 mins by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 5.90nMpH: 8.0 T: 2°CAssay Description:This spectrophotometric assay is based on the reaction of
5,5-dithio-bis(2-nitrobenzoic)acid (DTNB) with thiocholine to yield a
colored product. Sh...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Compound was evaluated for the in vitro inhibition of the Butyrylcholinesterase from horse serumMore data for this Ligand-Target Pair
Affinity DataIC50: 8.60nMpH: 8.0 T: 2°CAssay Description:Suitable agents like donepezil hydrochloride and tacrine hydrochloride hydrate were used as standards for this study. Buffer solution (50 mM Tris-HCl...More data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of rat plasma butyrylcholine esterase in presence of butyrylcholine substrate by chemiluminescent assayChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataIC50: 9.10nMpH: 8.0 T: 2°CAssay Description:The assay was carried out according to the Ellman method [Ellman et al., Biochem. Pharmacol., 7:88-95], optimized for 96-well microplates using a Tec...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of equine BChE preincubated for 15 mins by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of equine BChE incubated with compounf for 5 mins before addition of substrate S-butyrylthiocholine iodide by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 19.6nMpH: 7.4 T: 2°CAssay Description:The test was run as described in the following procedure: stock solution of the test compounds was diluted in phosphate buffer pH 7.4 to give final c...More data for this Ligand-Target Pair
Affinity DataIC50: 27.1nMAssay Description:Inhibition of equine BChE by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 30.0nMpH: 8.0Assay Description:All the assays were under 0.1 M KH2PO4/K2HPO4 buffer, pH 8.0, using a Shimadzu 2450 Spectrophotometer. Enzyme solutions were prepared to give 2 units...More data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:Inhibition of equine BChE after 15 mins by Ellman's method using acetylcholine as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 44nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
Affinity DataIC50: 44nMAssay Description:Inhibition of rat serum butyrylcholinesterase using butyrylthiocholine as substrate in presence of AChE inhibitor BW284C51 by spectrophotometric meth...More data for this Ligand-Target Pair
Affinity DataIC50: 55nMAssay Description:Compound was tested in vitro for inhibitory activity against ButyrylcholinesteraseMore data for this Ligand-Target Pair
Affinity DataIC50: 73nMAssay Description:In vitro inhibitory concentration of the compound against Butyrylcholinesterase obtained from rat plasmaMore data for this Ligand-Target Pair
Affinity DataIC50: 73nMAssay Description:Inhibitory concentration was determined in in vitro for Butyrylcholinesterase in rat plasmaMore data for this Ligand-Target Pair
Affinity DataIC50: 74nMAssay Description:Inhibition of rat cortex homogenate BuChE by spectrophotometric methodMore data for this Ligand-Target Pair
Affinity DataIC50: 80nMAssay Description:Inhibition of rat serum BChE using butyrylthiocholine iodide as substrate after 20 mins by by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 92nMAssay Description:Inhibition of rat serum BChEMore data for this Ligand-Target Pair
Affinity DataIC50: 92nMAssay Description:Inhibitory potency against rat serum Butyrylcholinesterase with BW284c51 as AChE inhibitorMore data for this Ligand-Target Pair
Affinity DataIC50: 92nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
Affinity DataIC50: 92nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The appearance of product was monitored at 412 nm for 5 min us...More data for this Ligand-Target Pair
Affinity DataIC50: 92nMpH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
Affinity DataIC50: 92nMAssay Description:Inhibition of rat serum BuChEMore data for this Ligand-Target Pair
Affinity DataIC50: 147nMAssay Description:Inhibition of rat serum BChE using butyrylthiocholine iodide as substrate by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 240nMAssay Description:Inhibitory concentration against rat brain butyrylcholinesterase (BuChE) was determined using Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 280nMpH: 8.0Assay Description:The target compounds were dissolved in a mixture of 1 mL DMSO and 9 mL methanol and diluted in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0) to obtain final co...More data for this Ligand-Target Pair
