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Report error Found 5920 of affinity data for UniProtKB/TrEMBL: Q9Y5N1
TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50138119(CHEMBL3753475)
Affinity DataKi:  0.0300nMAssay Description:Binding affinity to recombinant human H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50246381(2-(4-(1-cyclobutylpiperidin-4-yloxy)phenyl)-3,8-di...)
Affinity DataKi:  0.0313nMAssay Description:Displacement of [125I]Iodoproxyfan from human recombinant histamine H3 receptor by Competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50277100(4-(3-Piperidin-1-yl-propoxy)-benzoic acid 2-{4-[3-...)
Affinity DataKi:  0.0420nMAssay Description:Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in CHO/HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50492784(CHEMBL2413837)
Affinity DataKi:  0.0450nMAssay Description:Displacement of [125I]iodoproxyfan from histamine H3 receptor (unknown origin) expressed in CHO cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50319536((R)-2-(4-methylpiperidin-1-yl)-6-(2-(2-methylpyrro...)
Affinity DataKi:  0.0500nMAssay Description:Displacement of [125I]Iodoproxyfan from human recombinant histamine H3 receptor by Competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50174619(CHEMBL197747 | {2-[2-((R)-2-Methyl-pyrrolidin-1-yl...)
Affinity DataKi:  0.0500nMAssay Description:In vitro binding affinity for human histamine H3 receptor using [3H]-N-alpha-methylhistamineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50319536((R)-2-(4-methylpiperidin-1-yl)-6-(2-(2-methylpyrro...)
Affinity DataKi:  0.0500nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human cloned histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50492781(CHEMBL2413835)
Affinity DataKi:  0.0570nMAssay Description:Displacement of [125I]iodoproxyfan from histamine H3 receptor (unknown origin) expressed in CHO cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50159110(1-(3-(4-(piperidin-1-ylmethyl)phenoxy)propyl)piper...)
Affinity DataKi:  0.0603nMAssay Description:Binding affinity in Nluc-hH3R assessed in HEK293 cells by NanoBRET binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50246382(8-chloro-2-(4-(1-cyclobutylpiperidin-4-yloxy)pheny...)
Affinity DataKi:  0.0625nMAssay Description:Displacement of [125I]Iodoproxyfan from human recombinant histamine H3 receptor by Competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50278495(4-chloro-1-(4-(3-(piperidin-1-yl)propoxy)benzyl)pi...)
Affinity DataKi:  0.0680nMAssay Description:Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in HEL293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50246290(2-(4-(1-cyclobutylpiperidin-4-yloxy)phenyl)-3-meth...)
Affinity DataKi:  0.0688nMAssay Description:Displacement of [125I]Iodoproxyfan from human recombinant histamine H3 receptor by Competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50246434(2-(4-(1-cyclobutylpiperidin-4-yloxy)phenyl)-8-fluo...)
Affinity DataKi:  0.0781nMAssay Description:Displacement of [125I]Iodoproxyfan from human recombinant histamine H3 receptor by Competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50158590(1-(3-{2-[2-((R)-2-Methyl-pyrrolidin-1-yl)-ethyl]-b...)
Affinity DataKi:  0.0800nMAssay Description:In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50174627(CHEMBL199245 | {2-[2-((R)-2-Methyl-pyrrolidin-1-yl...)
Affinity DataKi:  0.0800nMAssay Description:In vitro binding affinity for human histamine H3 receptor using [3H]-N-alpha-methylhistamineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50110291((7-Chloro-quinolin-4-yl)-[4-(3-piperidin-1-yl-prop...)
Affinity DataKi:  0.0860nMAssay Description:Affinity for displacement of [125I]-iodoproxyfan from human histamine H3 receptors stably expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50158588((3,5-Difluoro-phenyl)-{2-[2-((R)-2-methyl-pyrrolid...)
Affinity DataKi:  0.0900nMAssay Description:In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50110288(CHEMBL15153 | N-(4-(3-(piperidin-1-yl)propoxy)phen...)
Affinity DataKi:  0.0910nMAssay Description:Affinity for displacement of [125I]-iodoproxyfan from human histamine H3 receptors stably expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50278350(4-fluoro-1-(4-(3-(piperidin-1-yl)propoxy)benzyl)pi...)
Affinity DataKi:  0.0933nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in HEK293 cells after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50246435(2-(4-(1-cyclobutylpiperidin-4-yloxy)phenyl)-8-meth...)
Affinity DataKi:  0.0938nMAssay Description:Displacement of [125I]Iodoproxyfan from human recombinant histamine H3 receptor by Competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50246334(2-(4-(1-cyclobutylpiperidin-4-yloxy)phenyl)-7-meth...)
Affinity DataKi:  0.0938nMAssay Description:Displacement of [125I]Iodoproxyfan from human recombinant histamine H3 receptor by Competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50246333(2-(4-(1-cyclobutylpiperidin-4-yloxy)phenyl)-6-meth...)
Affinity DataKi:  0.0938nMAssay Description:Displacement of [125I]Iodoproxyfan from human recombinant histamine H3 receptor by Competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50278350(4-fluoro-1-(4-(3-(piperidin-1-yl)propoxy)benzyl)pi...)
Affinity DataKi:  0.0940nMAssay Description:Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in HEL293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50278350(4-fluoro-1-(4-(3-(piperidin-1-yl)propoxy)benzyl)pi...)
Affinity DataKi:  0.0940nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 receptor expressed in HEK293 cells after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50246287(3-benzyl-2-(4-(3-(piperidin-1-yl)propoxy)phenyl)qu...)
Affinity DataKi:  0.0969nMAssay Description:Displacement of [125I]Iodoproxyfan from human recombinant histamine H3 receptor by Competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50492783(CHEMBL2413824)
Affinity DataKi:  0.100nMAssay Description:Displacement of [125I]iodoproxyfan from histamine H3 receptor (unknown origin) expressed in CHO cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50158596((3-Fluoro-phenyl)-{2-[2-((R)-2-methyl-pyrrolidin-1...)
Affinity DataKi:  0.100nMAssay Description:In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50319554((R)-2-(2-methylimidazo[1,2-a]pyridin-3-yl)-6-(2-(2...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [125I]Iodoproxyfan from human recombinant histamine H3 receptor by Competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50319552((R)-6-methyl-5-(6-(2-(2-methylpyrrolidin-1-yl)ethy...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [125I]Iodoproxyfan from human recombinant histamine H3 receptor by Competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50319549((R)-5-methyl-4-(6-(2-(2-methylpyrrolidin-1-yl)ethy...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [125I]Iodoproxyfan from human recombinant histamine H3 receptor by Competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM197114(US9216182, 1.60)
Affinity DataKi:  0.100nMAssay Description:The potency of compounds of the invention as H3 receptor antagonists can be assessed by measuring the blockade of (R)-alpha-methylhistamine-mediated ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50319509((R)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)-2-(pyridi...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [125I]Iodoproxyfan from human recombinant histamine H3 receptor by Competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50319549((R)-5-methyl-4-(6-(2-(2-methylpyrrolidin-1-yl)ethy...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human cloned histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50319552((R)-6-methyl-5-(6-(2-(2-methylpyrrolidin-1-yl)ethy...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human cloned histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50264895(5-fluoro-1-(4-(3-(piperidin-1-yl)propoxy)phenyl)-2...)
Affinity DataKi:  0.100nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in HEK293 cells assessed as reversal of N-alpha-methylhistamine-induced inhibition of fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50138124(CHEMBL3753901)
Affinity DataKi:  0.100nMAssay Description:Binding affinity to recombinant human H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50319538((R)-1-(4-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)quin...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [125I]Iodoproxyfan from human recombinant histamine H3 receptor by Competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50319517((R)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)-2-(pyrazi...)
Affinity DataKi:  0.110nMAssay Description:Displacement of [125I]Iodoproxyfan from human recombinant histamine H3 receptor by Competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50174621(CHEMBL196467 | {2-[2-((R)-2-Methyl-pyrrolidin-1-yl...)
Affinity DataKi:  0.110nMAssay Description:In vitro binding affinity for human histamine H3 receptor using [3H]-N-alpha-methylhistamineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50319509((R)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)-2-(pyridi...)
Affinity DataKi:  0.110nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human cloned histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50319517((R)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)-2-(pyrazi...)
Affinity DataKi:  0.110nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human cloned histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50319538((R)-1-(4-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)quin...)
Affinity DataKi:  0.120nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human cloned histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50319554((R)-2-(2-methylimidazo[1,2-a]pyridin-3-yl)-6-(2-(2...)
Affinity DataKi:  0.120nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human cloned histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50247054(6-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-benzo[d]azep...)
Affinity DataKi:  0.120nMAssay Description:Binding affinity to histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50200642((S)-4-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)naphtha...)
Affinity DataKi:  0.120nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in C6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50392759(CHEMBL2151157)
Affinity DataKi:  0.126nMAssay Description:Displacement of [3H]N-alpha-Methylhistamine from human recombinant H3 receptor expressed in HEK293 cells by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50247054(6-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-benzo[d]azep...)
Affinity DataKi:  0.126nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50174613(4-({2-[2-((R)-2-Methyl-pyrrolidin-1-yl)-ethyl]-ben...)
Affinity DataKi:  0.130nMAssay Description:In vitro binding affinity for human histamine H3 receptor using [3H]-N-alpha-methylhistamineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50492772(CHEMBL2413828)
Affinity DataKi:  0.130nMAssay Description:Displacement of [125I]iodoproxyfan from histamine H3 receptor (unknown origin) expressed in CHO cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetHistamine H3 receptor(Human)
Suven Life Sciences

Curated by ChEMBL
LigandPNGBDBM50174637(CHEMBL196294 | {2-[2-((R)-2-Methyl-pyrrolidin-1-yl...)
Affinity DataKi:  0.140nMAssay Description:In vitro binding affinity for human histamine H3 receptor using [3H]-N-alpha-methylhistamineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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