Binding Database

BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 2.9M data for 1.3M Compounds and 9.3K Targets. Of those, 1,388K data for 649K Compounds and 4.5K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

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10 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review

PMID

Data

Article Title

Organization

Ras inhibition via direct Ras binding--is there a path forward?

Genentech

Synthesis and antitumor activity of new benzoheterocyclic derivatives of distamycin A.

University of Ferrara

Design, synthesis and biological activity of a pyrrolo [2,1-c][1,4]benzodiazepine (PBD)-distamycin hybrid.

University of Ferrara

Synthesis and evaluation of pyrazolo[3,4-b]quinoline ribofuranosides and their derivatives as inhibitors of oncogenic Ras

TBA

Targeting mutated GTPase KRAS in tumor therapies.

Sun Yat-Sen University

Zinc enzymes in medicinal chemistry.

Hefei University of Technology

Targeting KRAS mutant cancers by preventing signaling transduction in the MAPK pathway.

Massachusetts College of Pharmacy and Health Sciences University

Fragment-to-Lead Medicinal Chemistry Publications in 2018.

Frontier Medicines

C-terminal modifications of histidyl-N-benzylglycinamides to give improved inhibition of Ras farnesyltransferase, cellular activity, and anticancer activity in mice.

Warner-Lambert

Ophirapstanol trisulfate, a new biologically active steroid sulfate from the deep water marine sponge Topsentia ophiraphidites.

Harbor Branch Oceanographic Institution