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Report error Found 24 Enz. Inhib. hit(s) with all data for entry = 50017349
TargetGTPase NRas(Human)
Massachusetts College of Pharmacy and Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50097071(4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]MET...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity to NRAS (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
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TargetGTPase HRas(Human)
Massachusetts College of Pharmacy and Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50097071(4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]MET...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity to HRAS (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
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TargetGTPase HRas(Human)
Massachusetts College of Pharmacy and Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50092365((R)-1-((1H-imidazol-5-yl)methyl)-3-benzyl-4-(thiop...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of HRAS (unknown origin) farnesylationMore data for this Ligand-Target Pair
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TargetProtein farnesyltransferase subunit beta(Human)
Massachusetts College of Pharmacy and Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50601397(CHEMBL5175962)
Affinity DataIC50:  1.80nMAssay Description:Displacement of M [3H] farnesyl diphosphate from human PFTase expressed in Escherichia coliMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetGTPase KRas(Human)
Massachusetts College of Pharmacy and Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50092365((R)-1-((1H-imidazol-5-yl)methyl)-3-benzyl-4-(thiop...)
Affinity DataIC50:  8.40nMAssay Description:Inhibition of K-Ras (unknown origin) farnesylationMore data for this Ligand-Target Pair
In DepthDetails PubMed

TargetGTPase HRas(Human)
Massachusetts College of Pharmacy and Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50601400(CHEMBL5171806)
Affinity DataIC50:  100nMAssay Description:Inhibition of HRAS (unknown origin) transfected in BALB/c nude mouse incubated for 3 days measured by immunoblot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetGTPase HRas(Human)
Massachusetts College of Pharmacy and Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50601398(CHEMBL5174384)
Affinity DataIC50:  100nMAssay Description:Inhibition of [35S]methionine labelled HRAS in rat Rat1 cells by immunoprecipitation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetGTPase KRas(Human)
Massachusetts College of Pharmacy and Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50459706(CHEMBL4214264)
Affinity DataIC50:  120nMAssay Description:Inhibition of recombinant full length FLAG tagged KRAS G12C mutant (1 to 169 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
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TargetGTPase KRas(Human)
Massachusetts College of Pharmacy and Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50601391(CHEMBL2086790 | SCH-53870)
Affinity DataIC50:  500nMAssay Description:Binding affinity to GDP-bound KRAS G12V RAS mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetGTPase KRas(Human)
Massachusetts College of Pharmacy and Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50601392(CHEMBL5176540)
Affinity DataIC50:  500nMAssay Description:Binding affinity to GDP-bound KRAS G12V RAS mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetGTPase KRas(Human)
Massachusetts College of Pharmacy and Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50421183(CHEMBL2086789)
Affinity DataIC50:  700nMAssay Description:Binding affinity to GDP-bound KRAS G12V RAS mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed

TargetGTPase KRas(Human)
Massachusetts College of Pharmacy and Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50601395(CHEMBL5178832)
Affinity DataIC50:  726nMAssay Description:Inhibition of KRAS G12C mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetGTPase KRas(Human)
Massachusetts College of Pharmacy and Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50503649(CHEMBL4476113)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of recombinant full length FLAG tagged KRAS G12C mutant (1 to 169 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
In DepthDetails PubMed

TargetGTPase KRas(Human)
Massachusetts College of Pharmacy and Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50092365((R)-1-((1H-imidazol-5-yl)methyl)-3-benzyl-4-(thiop...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of K-Ras (unknown origin) geranylgeranylationMore data for this Ligand-Target Pair
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TargetGTPase KRas(Human)
Massachusetts College of Pharmacy and Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50127227((R)-2,4,6-Trimethyl-deca-2,4-dienoic acid {(1S,5S,...)
Affinity DataIC50:  3.58E+3nMAssay Description:Antiproliferative activity against human COLO 320DM cells harboring wild type KRAS assessed as reduction in cell viability incubated for 24 hrs in pr...More data for this Ligand-Target Pair
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TargetGTPase KRas(Human)
Massachusetts College of Pharmacy and Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50601399(CHEMBL5191267)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of KRAS G12V mutant (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of post-translational modification processingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetGTPase HRas(Human)
Massachusetts College of Pharmacy and Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50601396(CHEMBL5197181)
Affinity DataIC50:  3.55E+4nMAssay Description:Inhibition of human p21 h-RAS assessed as reduction in C-Cdc25 stimulated nucleotide exchange by luminescence spectrometer based analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed

TargetGTPase HRas(Human)
Massachusetts College of Pharmacy and Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50601391(CHEMBL2086790 | SCH-53870)
Affinity DataIC50:  5.60E+4nMAssay Description:Inhibition of human p21 h-RAS assessed as reduction in C-Cdc25 stimulated nucleotide exchange by luminescence spectrometer based analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetGTPase KRas(Human)
Massachusetts College of Pharmacy and Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50539763(Adagrasib | Mrtx-849 | Mrtx849)
Affinity DataEC50:  10nMAssay Description:Inhibition of KRAS (unknown origin) dependent signal transductionMore data for this Ligand-Target Pair
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TargetGTPase KRas(Human)
Massachusetts College of Pharmacy and Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50601393(CHEMBL2086794)
Affinity DataKd:  1.30E+6nMAssay Description:Binding affinity to GDP-bound KRAS G12D mutant (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed

TargetGTPase KRas(Human)
Massachusetts College of Pharmacy and Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50088363(CHEMBL2086796)
Affinity DataKd:  3.40E+5nMAssay Description:Binding affinity to GDP-bound KRAS G12D mutant (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails PubMed

TargetGTPase KRas(Human)
Massachusetts College of Pharmacy and Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50436053(CHEMBL2396992)
Affinity DataKd:  1.10E+6nMAssay Description:Binding affinity to KRAS (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails PubMedPDB3D3D Structure (crystal)

TargetGTPase KRas(Human)
Massachusetts College of Pharmacy and Health Sciences University

Curated by ChEMBL
LigandPNGBDBM7939(1H-1,3-benzodiazole | Benzimidazole | Benzimidazol...)
Affinity DataKd:  1.50E+6nMAssay Description:Binding affinity to KRAS (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails PubMedPDB3D3D Structure (crystal)

TargetGTPase KRas(Human)
Massachusetts College of Pharmacy and Health Sciences University

Curated by ChEMBL
LigandPNGBDBM50601394(CHEMBL5176776)
Affinity DataKd:  1.90E+5nMAssay Description:Binding affinity to GDP-bound KRAS G12D mutant (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed