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Found 5 Enz. Inhib. hit(s) with Target = 'GTPase KRas' and Ligand = 'BDBM50436053'
TargetGTPase KRas(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50436053(CHEMBL2396992)
Affinity DataIC50:  1.55E+5nMAssay Description:Inhibition of KRas (unknown origin) by nucleotide release assayMore data for this Ligand-Target Pair
TargetGTPase KRas(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50436053(CHEMBL2396992)
Affinity DataIC50:  1.55E+5nMAssay Description:Inhibition of full-length human KRas4B (amino acids 1 to 188)-SOS interaction assessed as inhibition of SOS-mediated nucleotide release activityMore data for this Ligand-Target Pair
TargetGTPase KRas(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50436053(CHEMBL2396992)
Affinity DataIC50:  3.42E+5nMAssay Description:Inhibition of full-length human KRas4B (amino acids 1 to 188)-SOS interaction assessed as inhibition of nucleotide exchange activityMore data for this Ligand-Target Pair
TargetGTPase KRas(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50436053(CHEMBL2396992)
Affinity DataEC50:  1.58E+4nMAssay Description:Inhibition of KRas activation in HEK 293T-REx Flp-In cells harboring Venus-RBD-CRD/mCherry-CAAX assessed as reduction in Venus-RBD-CRD recruitment to...More data for this Ligand-Target Pair
TargetGTPase KRas(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50436053(CHEMBL2396992)
Affinity DataKd:  1.10E+6nMAssay Description:Binding affinity to KRAS (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair