Found 9 Enz. Inhib. hit(s) with Target = 'GTPase KRas' and Ligand = 'BDBM50459706' 
Affinity DataKi: 3.10E+4nMAssay Description:Binding affinity to KRAS (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: >6.40E+4nMAssay Description:Binding affinity to hexahistidine-tagged recombinant human KRas G12C mutant expressed in Escherichia coli BL21 (DE3) in presence of GDPMore data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 24 hrs by immunoblot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of KRas G12C mutant in human H358 cells assessed as reduction in ERK phosphorylation at T202/Y204 residue incubated for 24 hrs by immunobl...More data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of recombinant full length FLAG tagged KRAS G12C mutant (1 to 169 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
Affinity DataIC50: 831nMAssay Description:Inhibition of KRAS in human MIAPaca2 cells assessed as decrease in EGF-stimulated ERK1/2 phosphorylation preincubated for 2 hrs followed by EGF stimu...More data for this Ligand-Target Pair
Affinity DataIC50: 939nMAssay Description:Inhibition of GDP bound recombinant human His-tagged KRAS G12C/C118A mutant (1 to 169 residues) assessed as reduction in SOS1-mediated GDP/GTP nucleo...More data for this Ligand-Target Pair
Affinity DataIC50: 1.59E+3nMAssay Description:Covalent binding affinity to KRAS G12C mutant at Cys12 residue in human NCI-H358 cells assessed as reduction of log2 H/L ratio for tryptic peptide LV...More data for this Ligand-Target Pair
Affinity DataIC50: 1.80E+3nMAssay Description:Covalent binding affinity to KRAS G12C mutant at Cys12 residue in human NCI-H358 cells assessed as reduction of log2 H/L ratio for tryptic peptide LV...More data for this Ligand-Target Pair
