PMID

Data

Article Title

Organization

Discovery of 5-aryl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-ones as positive allosteric modulators of metabotropic glutamate subtype-2 (mGlu2) receptors with efficacy in a preclinical model of psychosis.

Merck Research Laboratories

Discovery of 2-[5-(4-Fluorophenylcarbamoyl)pyridin-2-ylsulfanylmethyl]phenylboronic Acid (SX-517): Noncompetitive Boronic Acid Antagonist of CXCR1 and CXCR2.

Syntrix Biosystems

Identification, biological characterization and pharmacophoric analysis of a new potent and selective NK1 receptor antagonist clinical candidate.

Glaxosmithkline

Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells.

Broad Institute of Mit and Harvard

Novel phomactin analogues as PAF receptor ligands.

The University of Nottingham

Designed multiple ligands. An emerging drug discovery paradigm.

Organon Laboratories

Development, synthesis, and biological evaluation of (-)-trans-(2S,5S)-2-[3-[(2-oxopropyl)sulfonyl]-4-n-propoxy-5-(3- hydroxypropoxy)-phenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran, a potent orally active platelet-activating factor (PAF) antagonist and its water-soluble prodrug phosphate ester.

Merck Research Laboratories

A 3D-QSAR study on ginkgolides and their analogues with comparative molecular field analysis.

Chinese Academy of Sciences

 

Cyclic ether acetal platelet activating factor (PAF) receptor antagonists II: imidazo[4,5-c]pyridyl derivatives

TBA

 

Cyclic ether acetal platelet activating factor (PAF) receptor antagonists I: 3-pyridyl derivatives

TBA

 

A partial pharmacophore for the platelet activating factor (PAF) receptor

TBA

 

Synthesis and biological activity of the platelet-activating factor antagonist ()-trans-2-(3-methoxy-4-phenylsulfonylethoxy-5-n-propylsulfonylphenyl)-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran (L-671,284) and its analogs

TBA

 

Synthesis and biological activity of MK 287 (L-680,573): a potent, specific and orally active paf receptor antagonist

TBA

 

Cmi-206: A potent dual platelet activating factor antagonist and 5-lipoxygenase inhibitor

TBA

 

Enantiodifferentiation of dihydropyridine PAF antagonists

TBA

Discovery of a novel, orally active, small molecule gonadotropin-releasing hormone (GnRH) receptor antagonist.

Pfizer

Chemistry, biosynthesis and biological activity of terpenoids and meroterpenoids in bacteria and fungi isolated from different marine habitats.

Iranian Fisheries Science Research Institute

(+/-)-trans-2-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-(N-methyl-N- hydroxyureidyl)methylphenyl]-5-(3,4, 5-trimethoxyphenyl)tetrahydrofuran (CMI-392), a potent dual 5-lipoxygenase inhibitor and platelet-activating factor receptor antagonist.

University of Virginia

Structural modification of 5-aryl-2,3-dihydroimidazo[2,1-a]isoquinoline platelet activating factor receptor antagonists.

Sandoz Research Institute

Antitumor activity of 5-aryl-2,3-dihydroimidazo[2,1-a]isoquinolines.

Sandoz Research Institute

Pyrido[2,1-b]quinazolinecarboxamide derivatives as platelet activating factor antagonists.

Hoffmann-La Roche

Pentadienyl carboxamide derivatives as antagonists of platelet-activating factor.

Roche Research Center

Biphenylcarboxamide derivatives as antagonists of platelet-activating factor.

Roche Research Center

Propenyl carboxamide derivatives as antagonists of platelet activating factor.

Hoffmann-La Roche

Thienotriazolodiazepines as platelet-activating factor antagonists. Steric limitations for the substituent in position 2.

Roche Research Center

Triazolobenzo- and triazolothienodiazepines as potent antagonists of platelet activating factor.

Roche Research Center

Dual antagonists of platelet activating factor and histamine. Identification of structural requirements for dual activity of N-Acyl-4-(5,6-dihydro-11H-benzo [5,6]cyclohepta-[1,2-b]pyridin-11-ylidene)piperidines.

Schering-Plough

Synthesis, Biological Evaluation, and Molecular Docking of 8-imino-2-oxo-2H,8H-pyrano[2,3-f]chromene Analogs: New Dual AChE Inhibitors as Potential Drugs for the Treatment of Alzheimer's Disease.

Yogi Vemana University

Phosphorylation of Capsaicinoid Derivatives Provides Highly Potent and Selective Inhibitors of the Transcription Factor STAT5b.

University of Leipzig