BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.2M data for 1.4M Compounds and 11.5K Targets. Of those, 1.6M data for 765K Compounds and 4.8K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

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To help with training and testing AI and other models, BindingDB downloads and search results now provide the publication date and BindingDB curation date of each measurement.

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8 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Cmpds
Data
Article Title
Organization
20
BMS-871: a novel orally active pan-Notch inhibitor as an anticancer agent.EBI
Bristol Myers Squibb
6
Discovery of Clinical Candidate PF-06648671: A Potent γ-Secretase Modulator for the Treatment of Alzheimer's Disease.EBI
Pfizer
21
Stepwise Design of γ-Secretase Modulators with an Advanced Profile by Judicious Coordinated Structural Replacements and an Unconventional Phenyl Ring Bioisostere.EBI
F. Hoffmann-La Roche
32
Discovery of RO7185876, a Highly Potent γ-Secretase Modulator (GSM) as a Potential Treatment for Alzheimer's Disease.EBI
F. Hoffmann-La Roche
24
b-Annulated 1,4-dihydropyridines as Notch inhibitors.EBI
Human Biomolecular Research Institute
5
The Notch Inhibitors Isolated from Nerium indicum.EBI
Chiba University
8
Notch Inhibitors from Calotropis gigantea That Induce Neuronal Differentiation of Neural Stem Cells.EBI
Chiba University