11 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
Data
Article Title
Organization
Discovery of a 1,2-bis(3-indolyl)ethane that selectively inhibits the pyruvate kinase of methicillin-resistant Staphylococcus aureus over human isoforms.
University of British Columbia
Use of adenine nucleotide derivatives to assess the potential of exo-active-site-directed reagents as species- or isozyme-specific enzyme inactivators. 2. Isozyme-specific inactivation of a mammalian enzyme and its significance in the possible design of fetal isozyme targeted antineoplastic agents.
TBA
Species- or isozyme-specific enzyme inhibitors. 9. Selective effects in inhibitions of rat pyruvate kinase isozymes by adenosine 5'-diphosphate derivatives.
TBA
Emerging and Re-emerging Warheads for Targeted Covalent Inhibitors: An Update.
Eberhard Karls University Tubingen
Sulfone-based human liver pyruvate kinase inhibitors - Design, synthesis and in vitro bioactivity.
University of Gothenburg
Tuning liver pyruvate kinase activity up or down with a new class of allosteric modulators.
University of Gothenburg
Anthraquinone derivatives as ADP-competitive inhibitors of liver pyruvate kinase.
University of Gothenburg
Tumor pyruvate kinase M2 modulators: a comprehensive account of activators and inhibitors as anticancer agents.
National Institute of Pharmaceutical Education and Research Ahmedabad
The search for pyruvate kinase-R activators; from a HTS screening hit via an impurity to the discovery of a lead series.
Pfizer Inc.
Discovery of novel naphthoquinone derivatives as inhibitors of the tumor cell specific M2 isoform of pyruvate kinase.
Peking University Health Science Center
WEE1 kinase inhibitors and methods of treating cancer using the same
University of Colorado