BDBM7497 1-Azakenpaullone::14-bromo-3,8,18-triazatetracyclo[9.7.0.0^{2,7}.0^{12,17}]octadeca-1(11),2,4,6,12(17),13,15-heptaen-9-one::US11759530, Compound Table1.11

SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4cccnc-34)c2c1

InChI Key InChIKey=NTSBZVCEIVPKBJ-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 7497   

TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Marthasterias glacialis (starfish))
Technische Universitat Braunschweig

LigandPNGBDBM7497(1-Azakenpaullone | 14-bromo-3,8,18-triazatetracycl...)
Affinity DataIC50:  2.00E+3nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Technische Universitat Braunschweig

LigandPNGBDBM7497(1-Azakenpaullone | 14-bromo-3,8,18-triazatetracycl...)
Affinity DataIC50:  4.20E+3nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Technische Universitat Braunschweig

LigandPNGBDBM7497(1-Azakenpaullone | 14-bromo-3,8,18-triazatetracycl...)
Affinity DataIC50:  18nMpH: 7.5 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Technische Universit£T Braunschweig

Curated by ChEMBL
LigandPNGBDBM7497(1-Azakenpaullone | 14-bromo-3,8,18-triazatetracycl...)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of recombinant CDK5/p25 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
City Of Hope

US Patent
LigandPNGBDBM7497(1-Azakenpaullone | 14-bromo-3,8,18-triazatetracycl...)
Affinity DataIC50:  18nMAssay Description:No assay is defined.More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM7497(1-Azakenpaullone | 14-bromo-3,8,18-triazatetracycl...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of CDK1/cyclinBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Technische Universitat Braunschweig

LigandPNGBDBM7497(1-Azakenpaullone | 14-bromo-3,8,18-triazatetracycl...)
Affinity DataIC50:  18nMAssay Description:Inhibition of rat GSK3beta expressed in Sf9 cells incubated for 30 mins using GS-1 peptide substrate and [gamma-32P]ATP by scintillation counting met...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Babasaheb Bhimrao Ambedkar University

Curated by ChEMBL
LigandPNGBDBM7497(1-Azakenpaullone | 14-bromo-3,8,18-triazatetracycl...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of GST-tagged CDK1/cyclin B (unknown origin) expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
City Of Hope

US Patent
LigandPNGBDBM7497(1-Azakenpaullone | 14-bromo-3,8,18-triazatetracycl...)
Affinity DataIC50:  18nMAssay Description:Inhibition of GSK3-betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed