BDBM50069989 (R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butylboronic acid::(R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-6-carboxamido)propanamido)butylboronic acid::BORTEZOMIB::CHEMBL325041::Dipeptidyl boronic acid derivative::LDP-341::N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE::PS-341::Peptidyl boronic acid derivative::US11542283, Compound Velcade::Velcade::cid_387447
SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O
InChI Key InChIKey=GXJABQQUPOEUTA-RDJZCZTQSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 122 hits for monomerid = 50069989
Affinity DataKi: 0.600nMAssay Description:Inhibition of human 20S proteasome chymotrypsin like activity using Suc-Leu-Leu-Val-Tyr-AMC as substrate measured over 10 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataKi: 9.80nMAssay Description:Inhibition of chymotrypsin-like activity of human 20S proteasome beta 5 subunit assessed as Suc-Leu-Leu-Val-Tyr-AMC substrate hydrolysis after 10 min...More data for this Ligand-Target Pair
Affinity DataKi: 9.80nMAssay Description:Inhibition of chymotrypsin-like activity of 20S proteasome in human erythrocytes using Suc-Leu-Leu-Val-Tyr-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataKi: 320nMAssay Description:Inhibitory activity against human ChymotrypsinogenMore data for this Ligand-Target Pair
Affinity DataKi: 630nMAssay Description:Inhibitory activity against human cathepsin GMore data for this Ligand-Target Pair
Affinity DataKi: 1.16E+3nMAssay Description:Inhibition of human CA2 by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.16E+3nMAssay Description:Inhibition of human carbonic anhydrase-2 preincubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.29E+3nMAssay Description:Inhibition of human carbonic anhydrase-1 preincubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.29E+3nMAssay Description:Inhibition of human CA1 by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 2.30E+3nMAssay Description:Inhibitory activity against human leukocyte elastaseMore data for this Ligand-Target Pair
Affinity DataKi: 2.40E+3nMAssay Description:Inhibition of bovine pancreatic alpha-chymotrypsin using Suc-Leu-Leu-Val-Tyr-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataKi: 2.68E+3nMAssay Description:Inhibition of mouse CA15 by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.28E+3nMAssay Description:Inhibition of human CA14 by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.38E+3nMAssay Description:Inhibition of human CA9 by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 4.38E+3nMAssay Description:Inhibition of human CA6 by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 4.57E+3nMAssay Description:Inhibition of human CA3 by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 5.87E+3nMAssay Description:Inhibition of human CA12 by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 6.51E+3nMAssay Description:Inhibition of human CA4 by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 6.83E+3nMAssay Description:Inhibition of human CA5B by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 6.92E+3nMAssay Description:Inhibition of human CA5A by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 6.94E+3nMAssay Description:Inhibition of human CA7 by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 8.45E+3nMAssay Description:Inhibition of human CA13 by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.30E+4nMAssay Description:Inhibitory activity against thrombinMore data for this Ligand-Target Pair
Affinity DataIC50: 8.96nMAssay Description:The assay was carried out in 50 uL volume, where 1 uL compound was added to 10 uL purified human proteasome (25 ug/mL) and incubated for 15 min and t...More data for this Ligand-Target Pair
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Southern Research Institute
Curated by PubChem BioAssay
Southern Research Institute
Curated by PubChem BioAssay
Affinity DataIC50: 78nMAssay Description:Inhibition of beta5i subunit of immunoproteasome (unknown origin) by active-site ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of caspase-like activity of human 20S proteasome using Ac-nLPnLD-AMC as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibition of beta5 subunit of immunoproteasome (unknown origin) by active-site ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of trypsin-like activity of human 20S proteasome using Ac-RLR-AMC as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of recombinant cathepsin B (unknown origin) using Z-Leu-Arg-AMC as substrate by spectrofluorometer analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of recombinant cathepsin G (unknown origin) using Suc-Ala-Ala-Pro-Phe-AMC as substrate by spectrofluorometer analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-LLVY-AMC as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 9.20E+3nMAssay Description:Inhibition of recombinant cathepsin A (unknown origin) using Mca-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys(Dnp)-OH as substrate incubated with enzyme for 5...More data for this Ligand-Target Pair
Affinity DataIC50: 7.10nMAssay Description:Inhibition of chymotrypsin-like enzyme activity of purified human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate by fluorescence methodMore data for this Ligand-Target Pair
Affinity DataIC50: 8.10nMAssay Description:Inhibition of chymotrypsin-like activity of LMP7 immunoproteasome by proteasome active site ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMAssay Description:Inhibition of chymotrypsin like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate preincubated for 10 mins followed by subs...More data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMAssay Description:Inhibition of chymotrypsin like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate preincubated for 10 mins followed by subs...More data for this Ligand-Target Pair
Affinity DataIC50: 6.20nMAssay Description:Inhibition of human 20S proteasome chymotryptic-like activity using Suc-LLVY-AMC as substrate measured for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7.10nMAssay Description:Inhibition of chymotrypsin like activity of human erythrocyte-derived 20S proteasome preincubated for 10 mins using Suc-LLVY-AMC as substrate after 6...More data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMAssay Description:Inhibition of chymotrypsin like activity of human 20S proteasome using ZGlyGlyLeuAMC/SucLeuLeuValTyrAMC as substrate measured every minute for 25 min...More data for this Ligand-Target Pair
Affinity DataIC50: 520nMAssay Description:Inhibition of human cathepsin GMore data for this Ligand-Target Pair
Affinity DataIC50: 1.19E+3nMAssay Description:Inhibition of human chymaseMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of chymotrypsin like activity of mouse spleen 20S proteasome beta5i subunit using Suc-Leu-Leu-Val-Tyr-AMC as substrate preincubated for 15...More data for this Ligand-Target Pair
Affinity DataIC50: 4.5nMAssay Description:Inhibition of chymotrypsin-like activity of human 20S proteasome beta 5 subunit using Suc-LLVY-AMC as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.88E+3nMAssay Description:Inhibition of trypsin-like activity of human 20S proteasome beta 2 subunit using Ac-RLR-AMC as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Inhibition of caspase-like activity of human 20S proteasome beta 1 subunit using Ac-nLPnLD-AMC as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 53nMAssay Description:Reversible inhibition of human erythrocyte derived 20S proteasome subunit beta1 after 30 mins by fluorogenic assayMore data for this Ligand-Target Pair
Affinity DataIC50: 590nMAssay Description:Reversible inhibition of human erythrocyte derived 20S proteasome subunit beta2 after 30 mins by fluorogenic assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7.90nMAssay Description:Reversible inhibition of human erythrocyte derived 20S proteasome subunit beta5 after 30 mins by fluorogenic assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.70nMAssay Description:Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair