Found 100 of ic50 for monomerid = 50069989 TargetProteasome subunit beta type-5(Homo sapiens (Human))
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-LLVY-MCA as substrate measured for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 1.30nMAssay Description:Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and me...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Affinity DataIC50: 1.90nMAssay Description:Inhibition of chymotrypsin like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate preincubated for 10 mins followed by subs...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Affinity DataIC50: 1.90nMAssay Description:Inhibition of chymotrypsin like activity of human 20S proteasome using ZGlyGlyLeuAMC/SucLeuLeuValTyrAMC as substrate measured every minute for 25 min...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Affinity DataIC50: 1.90nMAssay Description:Inhibition of chymotrypsin like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate preincubated for 10 mins followed by subs...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of human 20S immunoproteasome beta 5 subunit chymotrypsin-like activity using fluorogenic peptide Ac-WLA-AMC as substrate in presence of P...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Affinity DataIC50: 2.40nMAssay Description:In vitro inhibition of dihydropteroate synthase from Escherichia coli.More data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Affinity DataIC50: 2.80nMAssay Description:Inhibition of 20S proteasome beta5 subunit (unknown origin) using Suc-LLVY-AMC as flurogenic substrate measured after 1 hr by fluorescence based anal...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Affinity DataIC50: 2.80nMAssay Description:Inhibition of 20S proteasome beta5 subunit (unknown origin) using Suc-LLVY-AMC as flurogenic substrate measured after 1 hr by fluorescence based anal...More data for this Ligand-Target Pair
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human 20S immunoproteasome beta-1i subunit using (Ac-PAL)2R110 as substrate preincubated for 2 hrs followed by substrate addition and m...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of human peripheral blood derived 20s immunoproteasome beta1 caspase-like activity using Suc-PAL-AMC as substrate preincubated for 15 mins...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of human peripheral blood derived 20s immunoproteasome beta1 caspase-like activity using Suc-PAL-AMC as substrate preincubated for 15 mins...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human 20S proteasome beta5 subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and measured a...More data for this Ligand-Target Pair
Affinity DataIC50: 3.30nMAssay Description:Inhibition of 20S proteasome beta 5i (unknown origin) after 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of chymotrypsin-like activity of 26S proteasome beta 5 subunit in human U266 cells using Suc-LLVY-aminoluciferin as substrate after 1 hr b...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of chymotrypsin-like activity of 20S proteasome in human HL60 cells using Suc-LLVYaminoluciferin as substrate after 2 hrs by fluorescence ...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of human peripheral blood derived 20s immunoproteasome beta5 chymotrypsin-like activity using Suc-PAL-AMC as substrate preincubated for 15...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of chymotrypsin-like activity of 20S proteasome in human HL60 cells using Suc-LLVYaminoluciferin as substrate pretreated for 2 hrs followe...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of human peripheral blood derived 20s immunoproteasome beta5 chymotrypsin-like activity using Suc-PAL-AMC as substrate preincubated for 15...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Affinity DataIC50: 4.40nMAssay Description:Inhibition of chymotrypsin-like activity of 20S proteasome in human SEM cells using Suc-LLVY aminoluciferin as substrate after 2 hrs by proteasome-Gl...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Affinity DataIC50: 4.5nMAssay Description:Inhibition of chymotrypsin-like activity of human 20S proteasome beta 5 subunit using Suc-LLVY-AMC as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Affinity DataIC50: 4.70nMAssay Description:Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of human 20S immunoproteasome beta 1 subunit caspase-like activity using fluorogenic peptide Ac-nLPnLD-AMC as substrate in presence of PA2...More data for this Ligand-Target Pair
Affinity DataIC50: 5.5nMAssay Description:Inhibition of 20S proteasome beta 1i (unknown origin) after 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of human 20S constitutive proteasome beta 5 subunit chymotrypsin-like activity using fluorogenic peptide Ac-WLA-AMC as substrate in presen...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Affinity DataIC50: 6.20nMAssay Description:Inhibition of human 20S proteasome chymotryptic-like activity using Suc-LLVY-AMC as substrate measured for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Affinity DataIC50: 6.70nMAssay Description:Inhibition of chymotrypsin-like activity of 20S proteasome in human HL60 cells using Suc-LLVY aminoluciferin as substrate after 2 hrs by proteasome-G...More data for this Ligand-Target Pair
TargetA5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436(Homo sapiens (Human))
Zhejiang University
Curated by ChEMBL
Zhejiang University
Curated by ChEMBL
Affinity DataIC50: 6.90nMAssay Description:Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu Leu-Val-Tyr-AMC as substrate preincubated for 15 mins followed by subs...More data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-LLVY-AMC as substrateMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate incubated for 10 mins followed by substra...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of 20S proteasome beta 5c (unknown origin) after 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Affinity DataIC50: 7.10nMAssay Description:Inhibition of chymotrypsin like activity of human erythrocyte-derived 20S proteasome preincubated for 10 mins using Suc-LLVY-AMC as substrate after 6...More data for this Ligand-Target Pair
Affinity DataIC50: 7.10nMAssay Description:Inhibition of chymotrypsin-like enzyme activity of purified human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate by fluorescence methodMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Affinity DataIC50: 7.90nMAssay Description:Reversible inhibition of human erythrocyte derived 20S proteasome subunit beta5 after 30 mins by fluorogenic assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of human 20s immunoproteasome beta5i activity using Suc-LLVY-AMC as substrate preincubated for 15 mins followed by substrate additionMore data for this Ligand-Target Pair
Affinity DataIC50: 8.10nMAssay Description:Inhibition of chymotrypsin-like activity of LMP7 immunoproteasome by proteasome active site ELISAMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Affinity DataIC50: 8.30nMAssay Description:Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate after 1 hr by fluorescence analysisMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Affinity DataIC50: 8.96nMAssay Description:The assay was carried out in 50 uL volume, where 1 uL compound was added to 10 uL purified human proteasome (25 ug/mL) and incubated for 15 min and t...More data for this Ligand-Target Pair
TargetProteasome subunit alpha type-6(Homo sapiens (Human))
Jiangsu Chia Tai Fenghai Pharmaceutical
US Patent
Jiangsu Chia Tai Fenghai Pharmaceutical
US Patent
Affinity DataIC50: 9.92nMAssay Description:The proteasome used in the present invention is human erythrocyte 20S proteasome, and the enzyme, fluorescent substrate and test buffer are all purch...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of human 20s constitutive proteasome beta5 chymotrypsin-like activity using Suc-LLVY-AMC as substrate preincubated for 15 mins followed by...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of human hepatic cell derived 20s constitutive proteasome beta5 chymotrypsin-like activity using Suc-WLA-AMC as substrate preincubated for...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of human hepatic cell derived 20s constitutive proteasome beta5 chymotrypsin-like activity using Suc-WLA-AMC as substrate preincubated for...More data for this Ligand-Target Pair
TargetA5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436(Homo sapiens (Human))
Zhejiang University
Curated by ChEMBL
Zhejiang University
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate additionMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of chymotrypsin like activity of mouse spleen 20S proteasome beta5i subunit using Suc-Leu-Leu-Val-Tyr-AMC as substrate preincubated for 15...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-1(Homo sapiens (Human))
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Inhibition of PGPH activity of human 26S proteasome using Z-LLE-MCA as substrate measured for 1 hr by fluorescence assayMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-1(Homo sapiens (Human))
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Evaluated for norepinephrine as agonist.More data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of human 20S immunoproteasome beta1 subunit using Ac-nLPnLD-AMC as substrate preincubated for 2 hrs followed by substrate addition and mea...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Affinity DataIC50: 28nMAssay Description:Inhibition of chymotrypsin-like activity of 20S proteasome in imatinib-resistant human SUP-B15 cells using Suc-LLVY aminoluciferin as substrate after...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-1(Homo sapiens (Human))
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of caspase-like activity of 20S proteasome in human HL60 cells using Z-nLPnLDaminoluciferin as substrate after 2 hrs by fluorescence analy...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-1(Homo sapiens (Human))
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Nagahama Institute Of Bio-Science And Technology
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of PGPH-like activity of 20S proteasome in human HL60 cells using Z-nLPnLDaminoluciferin as substrate pretreated for 2 hrs followed by sub...More data for this Ligand-Target Pair
