BDBM50134315 7-hydroxy-11-hydroxymethyl-12-methyl-14,15-dithia-9,12-diazatetracyclo[9.2.2.01,9.03,8]pentadeca-3,5-diene-10,13-dione::CHEMBL331627::GLIOTOXIN
SMILES CN1C(=O)[C@]23CC4=CC=C[C@H](O)[C@H]4N2C(=O)[C@@]1(CO)SS3
InChI Key InChIKey=FIVPIPIDMRVLAY-RBJBARPLSA-N
Data 10 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 50134315
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Imperial College
Curated by ChEMBL
Imperial College
Curated by ChEMBL
Affinity DataIC50: 8.00E+4nMAssay Description:Inhibition of [3H]-FPP incorporation into recombinant human Ha-Ras-CVLS by farnesyl transferaseMore data for this Ligand-Target Pair
TargetAcetolactate synthase catalytic subunit, mitochondrial(Saccharomyces cerevisiae)
University Of California Santa Cruz
Curated by ChEMBL
University Of California Santa Cruz
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of Saccharomyces cerevisiae acetolactate synthaseMore data for this Ligand-Target Pair
TargetMycothiol S-conjugate amidase(Mycobacterium tuberculosis)
University Of California Santa Cruz
Curated by ChEMBL
University Of California Santa Cruz
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis mycothiol-S-conjugate amidaseMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
The University Of Tokyo
Curated by ChEMBL
The University Of Tokyo
Curated by ChEMBL
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibition of HMT-G9a using S-adenosylmethionine and biotinylated H3 peptide after 1 hrMore data for this Ligand-Target Pair
Affinity DataIC50: 2.26E+4nMAssay Description:Inhibition of PKM2 (unknown origin) Hie78, Arg73, Thr328 residues by coloroimetric/fluorometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 260nMAssay Description:Inhibition of SUV39H1More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
The University Of Tokyo
Curated by ChEMBL
The University Of Tokyo
Curated by ChEMBL
TargetGeranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Imperial College
Curated by ChEMBL
Imperial College
Curated by ChEMBL
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of [3H]-GGPP incorporation into recombinant human Ha-Ras-CVLL by Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase RNF31/RanBP-type and C3HC4-type zinc finger-containing protein 1/Sharpin(Homo sapiens)
Temple University
Curated by ChEMBL
Temple University
Curated by ChEMBL
Affinity DataIC50: 510nMAssay Description:Inhibition of petit-LUBAC (unknown origin)-mediated ubiquitylation expressed in Escherichia coli BL21 after 2 hrs in presence of E1, UbcH5c, E3 and u...More data for this Ligand-Target Pair
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Imperial College
Curated by ChEMBL
Imperial College
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Activity against FarnesyltransferaseMore data for this Ligand-Target Pair