BDBM50199404 1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-2,2-dimethyl-1,2,3,4-tetrahydro-isoquinolinium iodide::1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-2,2-dimethyl-1,2,3,4-tetrahydro-isoquinolinium; iodide::CHEMBL215370::N-Me-laudanosine::N-methyl-laudanosine

SMILES COc1ccc(C[C@H]2c3cc(OC)c(OC)cc3CC[N+]2(C)C)cc1OC

InChI Key InChIKey=RVBHVIRGZXRPRX-SFHVURJKSA-N

Data  4 KI  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50199404   

TargetSmall conductance calcium-activated potassium channel protein 1/2/3(Rattus norvegicus)
University Of Li£Ge

Curated by ChEMBL
LigandPNGBDBM50199404(1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-2,2-dimethy...)
Affinity DataKi:  1.30E+3nMAssay Description:Displacement of [125I]apamin from SK channel in Wistar rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmall conductance calcium-activated potassium channel protein 1/2/3(Rattus norvegicus)
University Of Li£Ge

Curated by ChEMBL
LigandPNGBDBM50199404(1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-2,2-dimethy...)
Affinity DataKi:  1.30E+3nMAssay Description:Displacement of [125I]apamin from Wistar rat cortical apamin-sensitive siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Rattus norvegicus)
Neurosearch

Curated by ChEMBL
LigandPNGBDBM50199404(1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-2,2-dimethy...)
Affinity DataKi:  1.50E+3nMAssay Description:Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmall conductance calcium-activated potassium channel protein 1/2/3(Rattus norvegicus)
University Of Li£Ge

Curated by ChEMBL
LigandPNGBDBM50199404(1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-2,2-dimethy...)
Affinity DataKi:  1.60E+3nMAssay Description:Inhibition of [125I]apamin binding to calcium-activated potassium (SK) channel of rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmall conductance calcium-activated potassium channel protein 1/2/3(Rattus norvegicus)
University Of Li£Ge

Curated by ChEMBL
LigandPNGBDBM50199404(1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-2,2-dimethy...)
Affinity DataIC50:  1.50E+4nMAssay Description:Blockade of SK channel in Wistar rat brain assessed as inhibition of apamin-sensitive after-hyperpolarisationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmall conductance calcium-activated potassium channel protein 3(Rattus norvegicus)
Neurosearch

Curated by ChEMBL
LigandPNGBDBM50199404(1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-2,2-dimethy...)
Affinity DataKd:  2.60E+3nMAssay Description:Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmall conductance calcium-activated potassium channel protein 1/2/3(Rattus norvegicus)
University Of Li£Ge

Curated by ChEMBL
LigandPNGBDBM50199404(1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-2,2-dimethy...)
Affinity DataIC50:  8.70E+3nMAssay Description:Inhibition of [125I]apamin binding to calcium-activated potassium (SK) channel of rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed