BDBM50598717 CHEMBL5193702::US20230348487, Example LS 6-45

SMILES [H][C@]12OC[C@@H](Oc3nc(Nc4ccc(N(C)CCN(C)C)c(NC(=O)C=C)c4)ncc3Cl)[C@@]1([H])OC[C@H]2OC

InChI Key InChIKey=MXXJXRACSRJBKS-OHUMZHCVSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50598717   

TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Guangzhou Salustier Biosciences

US Patent
LigandPNGBDBM50598717(CHEMBL5193702 | US20230348487, Example LS 6-45)
Affinity DataIC50:  1.53nMAssay Description:Test method: Firstly, test compounds were prepared into 10 mM stock solution with DMSO, and continuously diluted into 10 concentrations at a 3-fold g...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Guangzhou Salustier Biosciences

US Patent
LigandPNGBDBM50598717(CHEMBL5193702 | US20230348487, Example LS 6-45)
Affinity DataIC50:  1.30E+4nMAssay Description:Test method: Firstly, test compounds were prepared into 10 mM stock solution with DMSO, and continuously diluted into 10 concentrations at a 3-fold g...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Guangzhou Salustier Biosciences

US Patent
LigandPNGBDBM50598717(CHEMBL5193702 | US20230348487, Example LS 6-45)
Affinity DataIC50:  2.04E+3nMAssay Description:Test method: Firstly, test compounds were prepared into 10 mM stock solution with DMSO, and continuously diluted into 10 concentrations at a 3-fold g...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Guangzhou Salustier Biosciences

US Patent
LigandPNGBDBM50598717(CHEMBL5193702 | US20230348487, Example LS 6-45)
Affinity DataIC50:  1.25nMAssay Description:Test method: Firstly, test compounds were prepared into 10 mM stock solution with DMSO, and continuously diluted into 10 concentrations at a 3-fold g...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Guangzhou Salustier Biosciences

US Patent
LigandPNGBDBM50598717(CHEMBL5193702 | US20230348487, Example LS 6-45)
Affinity DataIC50:  1.09E+3nMAssay Description:Test method: Firstly, test compounds were prepared into 10 mM stock solution with DMSO, and continuously diluted into 10 concentrations at a 3-fold g...More data for this Ligand-Target Pair
In DepthDetails US Patent