BDBM50598717 CHEMBL5193702::US20230348487, Example LS 6-45

SMILES [H][C@]12OC[C@@H](Oc3nc(Nc4ccc(N(C)CCN(C)C)c(NC(=O)C=C)c4)ncc3Cl)[C@@]1([H])OC[C@H]2OC

InChI Key InChIKey=MXXJXRACSRJBKS-OHUMZHCVSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50598717   

TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50598717(CHEMBL5193702 | US20230348487, Example LS 6-45)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of GST tagged recombinant human JAK3 expressed in baculovirus infection system by FRET assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNUAK family SNF1-like kinase 1(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50598717(CHEMBL5193702 | US20230348487, Example LS 6-45)
Affinity DataIC50:  25nMAssay Description:Inhibition of human ARK5More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-Y/Cyclin-dependent kinase 16(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50598717(CHEMBL5193702 | US20230348487, Example LS 6-45)
Affinity DataIC50:  135nMAssay Description:Inhibition of human CDK16/cyclin-Y protein-protein complexMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50598717(CHEMBL5193702 | US20230348487, Example LS 6-45)
Affinity DataIC50:  132nMAssay Description:Inhibition of human FLT3More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50598717(CHEMBL5193702 | US20230348487, Example LS 6-45)
Affinity DataIC50:  4.73E+3nMAssay Description:Inhibition of human JAK1More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50598717(CHEMBL5193702 | US20230348487, Example LS 6-45)
Affinity DataIC50:  2.03E+3nMAssay Description:Inhibition of human JAK2More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50598717(CHEMBL5193702 | US20230348487, Example LS 6-45)
Affinity DataIC50:  1.53nMAssay Description:Test method: Firstly, test compounds were prepared into 10 mM stock solution with DMSO, and continuously diluted into 10 concentrations at a 3-fold g...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50598717(CHEMBL5193702 | US20230348487, Example LS 6-45)
Affinity DataIC50:  365nMAssay Description:Inhibition of human TYK2More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50598717(CHEMBL5193702 | US20230348487, Example LS 6-45)
Affinity DataIC50:  1.30E+4nMAssay Description:Test method: Firstly, test compounds were prepared into 10 mM stock solution with DMSO, and continuously diluted into 10 concentrations at a 3-fold g...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50598717(CHEMBL5193702 | US20230348487, Example LS 6-45)
Affinity DataIC50:  2.04E+3nMAssay Description:Test method: Firstly, test compounds were prepared into 10 mM stock solution with DMSO, and continuously diluted into 10 concentrations at a 3-fold g...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50598717(CHEMBL5193702 | US20230348487, Example LS 6-45)
Affinity DataIC50:  1.25nMAssay Description:Test method: Firstly, test compounds were prepared into 10 mM stock solution with DMSO, and continuously diluted into 10 concentrations at a 3-fold g...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50598717(CHEMBL5193702 | US20230348487, Example LS 6-45)
Affinity DataIC50:  1.09E+3nMAssay Description:Test method: Firstly, test compounds were prepared into 10 mM stock solution with DMSO, and continuously diluted into 10 concentrations at a 3-fold g...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50598717(CHEMBL5193702 | US20230348487, Example LS 6-45)
Affinity DataIC50:  8nMAssay Description:Inhibition of human JAK3More data for this Ligand-Target Pair
In DepthDetails PubMed