BDBM246872 US10053465, 11::US10065963, Compound 11::US10125150, Example 11::US10336759, # 11::US10479803, Example 11::US10519163, Example 11::US10675284, Example 11::US11084822, Example 11::US11130767, # 11::US11136326, Example 11::US11304949, Compound 11::US11324749, Comp. No. 11::US11406640, Comp. No. 11::US11596632, Comp. No. 11::US11918581, Compound 11::US20240058343, Compound 11::US9732097, Example 11::{trans-3-(4-{[4-[(3- hydroxyazetidin-1- yl)methyl]-6- (trifluoromethyl) pyridin-2- yl]oxy}piperidin-1- yl)-1-[4-(7H- pyrrolo[2,3- d]pyrimidin-4-yl)- 1H-pyrazol-1- yl]cydobutyl} acetonitrile

SMILES OC1CN(Cc2cc(OC3CCN(CC3)[C@H]3C[C@@](CC#N)(C3)n3cc(cn3)-c3ncnc4[nH]ccc34)nc(c2)C(F)(F)F)C1

InChI Key

Data  34 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 246872   

TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246872(US10053465, 11 | US10065963, Compound 11 | US10125...)
Affinity DataIC50:  300nMT: 2°CAssay Description:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246872(US10053465, 11 | US10065963, Compound 11 | US10125...)
Affinity DataIC50: >1.00E+3nMT: 2°CAssay Description:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246872(US10053465, 11 | US10065963, Compound 11 | US10125...)
Affinity DataIC50: >1.00E+3nMT: 2°CAssay Description:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246872(US10053465, 11 | US10065963, Compound 11 | US10125...)
Affinity DataIC50: <100nMT: 2°CAssay Description:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246872(US10053465, 11 | US10065963, Compound 11 | US10125...)
Affinity DataIC50:  300nMT: 2°CAssay Description:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246872(US10053465, 11 | US10065963, Compound 11 | US10125...)
Affinity DataIC50:  750nMT: 2°CAssay Description:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246872(US10053465, 11 | US10065963, Compound 11 | US10125...)
Affinity DataIC50: <10nMAssay Description:As used herein, a selective JAK1 inhibitor is an inhibitor of JAK1 which is selective for JAK1 over JAK2, JAK3 and TYK2. In some embodiments, the com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent