BDBM246872 US10053465, 11::US10065963, Compound 11::US10125150, Example 11::US10336759, # 11::US10479803, Example 11::US10519163, Example 11::US10675284, Example 11::US11084822, Example 11::US11130767, # 11::US11136326, Example 11::US11304949, Compound 11::US11324749, Comp. No. 11::US11406640, Comp. No. 11::US11596632, Comp. No. 11::US20240058343, Compound 11::US9732097, Example 11::{trans-3-(4-{[4-[(3- hydroxyazetidin-1- yl)methyl]-6- (trifluoromethyl) pyridin-2- yl]oxy}piperidin-1- yl)-1-[4-(7H- pyrrolo[2,3- d]pyrimidin-4-yl)- 1H-pyrazol-1- yl]cydobutyl} acetonitrile

SMILES OC1CN(Cc2cc(OC3CCN(CC3)[C@H]3C[C@@](CC#N)(C3)n3cc(cn3)-c3ncnc4[nH]ccc34)nc(c2)C(F)(F)F)C1

InChI Key

Data  33 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 246872   

TargetTyrosine-protein kinase JAK1 [837-1142](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246872(US10053465, 11 | US10065963, Compound 11 | US10125...)
Affinity DataIC50: <10nMAssay Description:Selective JAK1 inhibitors that can be used in combination with an immunomodulatory agent and steroid for the treatment of hematological diseases or d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent