BDBM253941 US9464092, GG::US9527857, GG

SMILES CC(C)N1CCN(CC1)c1ccc(Nc2ncc3cc4C(=O)NCC5(CCCCC5)n4c3n2)nc1

InChI Key InChIKey=YPJRHEKCFKOVRT-UHFFFAOYSA-N

Data  18 IC50  6 Kd  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 253941   

TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM253941(US9464092, GG | US9527857, GG)
Affinity DataKd:  22nMAssay Description:Binding affinity to human FLT3 D385V mutantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Nek10(Homo sapiens)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM253941(US9464092, GG | US9527857, GG)
Affinity DataKd:  0.200nMAssay Description:Binding affinity to NEK10 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM253941(US9464092, GG | US9527857, GG)
Affinity DataKd:  4.20nMAssay Description:Binding affinity to TTK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase ULK2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM253941(US9464092, GG | US9527857, GG)
Affinity DataKd:  5.5nMAssay Description:Binding affinity to ULK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM253941(US9464092, GG | US9527857, GG)
Affinity DataEC50: <100nMAssay Description:Inhibition of human CDK2/cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-H/Cyclin-dependent kinase 9(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM253941(US9464092, GG | US9527857, GG)
Affinity DataIC50:  280nMAssay Description:Inhibition of CDK9/cyclin H (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNUAK family SNF1-like kinase 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM253941(US9464092, GG | US9527857, GG)
Affinity DataKd:  0.700nMAssay Description:Binding affinity to SNARK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM253941(US9464092, GG | US9527857, GG)
Affinity DataKd:  6.5nMAssay Description:Binding affinity to human FLT3 ITD mutantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM253941(US9464092, GG | US9527857, GG)
Affinity DataEC50: <100nMAssay Description:Inhibition of human CDK4/cyclinD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed