BDBM253941 US9464092, GG::US9527857, GG

SMILES CC(C)N1CCN(CC1)c1ccc(Nc2ncc3cc4C(=O)NCC5(CCCCC5)n4c3n2)nc1

InChI Key InChIKey=YPJRHEKCFKOVRT-UHFFFAOYSA-N

Data  18 IC50  6 Kd  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 26 hits for monomerid = 253941   

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
G1 Therapeutics

US Patent
LigandPNGBDBM253941(US9464092, GG | US9527857, GG)
Affinity DataIC50:  1nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK6/CycD3 CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif....More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Mizoram University

Curated by ChEMBL
LigandPNGBDBM253941(US9464092, GG | US9527857, GG)
Affinity DataIC50:  28nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
G1 Therapeutics

US Patent
LigandPNGBDBM253941(US9464092, GG | US9527857, GG)
Affinity DataIC50:  1.51E+3nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK6/CycD3 CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif....More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
G1 Therapeutics

US Patent
LigandPNGBDBM253941(US9464092, GG | US9527857, GG)
Affinity DataIC50:  1.06nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK6/CycD3 CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif....More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
G1 Therapeutics

US Patent
LigandPNGBDBM253941(US9464092, GG | US9527857, GG)
Affinity DataIC50:  3.58nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK6/CycD3 CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif....More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
G1 Therapeutics

US Patent
LigandPNGBDBM253941(US9464092, GG | US9527857, GG)
Affinity DataIC50:  1.51nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK6/CycD3 CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif....More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
G1 Therapeutics

US Patent
LigandPNGBDBM253941(US9464092, GG | US9527857, GG)
Affinity DataIC50:  4.70nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK6/CycD3 CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif....More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
G1 Therapeutics

US Patent
LigandPNGBDBM253941(US9464092, GG | US9527857, GG)
Affinity DataIC50:  3.58E+3nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-A1/Cyclin-dependent kinase 2(Homo sapiens (Human))
Gi Therapeutics

US Patent
LigandPNGBDBM253941(US9464092, GG | US9527857, GG)
Affinity DataIC50:  1.51E+3nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
G1 Therapeutics

US Patent
LigandPNGBDBM253941(US9464092, GG | US9527857, GG)
Affinity DataIC50:  1nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
G1 Therapeutics

US Patent
LigandPNGBDBM253941(US9464092, GG | US9527857, GG)
Affinity DataIC50:  1.06nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
G1 Therapeutics

US Patent
LigandPNGBDBM253941(US9464092, GG | US9527857, GG)
Affinity DataIC50:  3.58E+3nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
G1 Therapeutics

US Patent
LigandPNGBDBM253941(US9464092, GG | US9527857, GG)
Affinity DataIC50:  1nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
G1 Therapeutics

US Patent
LigandPNGBDBM253941(US9464092, GG | US9527857, GG)
Affinity DataIC50:  1.51E+3nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM253941(US9464092, GG | US9527857, GG)
Affinity DataKd:  22nMAssay Description:Binding affinity to human FLT3 D385V mutantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Nek10(Homo sapiens)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM253941(US9464092, GG | US9527857, GG)
Affinity DataKd:  0.200nMAssay Description:Binding affinity to NEK10 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM253941(US9464092, GG | US9527857, GG)
Affinity DataKd:  4.20nMAssay Description:Binding affinity to TTK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase ULK2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM253941(US9464092, GG | US9527857, GG)
Affinity DataKd:  5.5nMAssay Description:Binding affinity to ULK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
G1 Therapeutics

US Patent
LigandPNGBDBM253941(US9464092, GG | US9527857, GG)
Affinity DataEC50: <100nMAssay Description:Inhibition of human CDK2/cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-H/Cyclin-dependent kinase 9(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM253941(US9464092, GG | US9527857, GG)
Affinity DataIC50:  280nMAssay Description:Inhibition of CDK9/cyclin H (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNUAK family SNF1-like kinase 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM253941(US9464092, GG | US9527857, GG)
Affinity DataKd:  0.700nMAssay Description:Binding affinity to SNARK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM253941(US9464092, GG | US9527857, GG)
Affinity DataKd:  6.5nMAssay Description:Binding affinity to human FLT3 ITD mutantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
G1 Therapeutics

US Patent
LigandPNGBDBM253941(US9464092, GG | US9527857, GG)
Affinity DataEC50: <100nMAssay Description:Inhibition of human CDK4/cyclinD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Mizoram University

Curated by ChEMBL
LigandPNGBDBM253941(US9464092, GG | US9527857, GG)
Affinity DataIC50:  1nMAssay Description:Inhibition of CDK4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 6(Homo sapiens (Human))
Mizoram University

Curated by ChEMBL
LigandPNGBDBM253941(US9464092, GG | US9527857, GG)
Affinity DataIC50:  2nMAssay Description:Inhibition of CDK6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
G1 Therapeutics

US Patent
LigandPNGBDBM253941(US9464092, GG | US9527857, GG)
Affinity DataIC50:  3.58E+3nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK6/CycD3 CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif....More data for this Ligand-Target Pair
In DepthDetails US Patent