BDBM5445 CHEMBL554::GW572016::LAPATINIB DITOSYLATE::Lapatinib::N-{3-chloro-4-[(3-fluoro-benzyl)oxy]phenyl}-6-[5-({2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine::N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(5-{[(2-methanesulfonylethyl)amino]methyl}furan-2-yl)quinazolin-4-amine::Tykerb::US10507209, Compound Lapatinib::US10822334, Compound Lapatinib::US9730934, Lapatinib ditosylate::cid_208908
SMILES CS(=O)(=O)CCNCc1ccc(o1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1
InChI Key InChIKey=BCFGMOOMADDAQU-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 5445
Affinity DataIC50: 7.90nMAssay Description:Inhibition of HER1 (unknown origin) assessed as reduction in autophosphorylation by ELISA methodMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Southeast University
Curated by ChEMBL
Southeast University
Curated by ChEMBL
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of PDGFRbeta (unknown origin) by ELISA methodMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Southeast University
Curated by ChEMBL
Southeast University
Curated by ChEMBL
Affinity DataIC50: 2.70nMAssay Description:Inhibition of HER2 (unknown origin) assessed as reduction in autophosphorylation by ELISA methodMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Southeast University
Curated by ChEMBL
Southeast University
Curated by ChEMBL
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of c-KIT (unknown origin) by ELISA methodMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Southeast University
Curated by ChEMBL
Southeast University
Curated by ChEMBL
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of KDR (unknown origin) by ELISA methodMore data for this Ligand-Target Pair