BDBM488392 2-[4-Amino-1-(1-methylsulfonyl-4- piperidyl)pyrazolo[3,4-d]pyrimidin-3-yl]-3-chloro- N-methyl-1H-indole-6-carboxamide::US10954241, Example 32::US11548896, Example 32
SMILES CNC(=O)c1ccc2c(Cl)c([nH]c2c1)-c1nn(C2CCN(CC2)S(C)(=O)=O)c2ncnc(N)c12
InChI Key InChIKey=HDRICYBPUIHGFB-UHFFFAOYSA-N
Data 6 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 488392
Affinity DataIC50: 7.93nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
Affinity DataIC50: 4.58E+3nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Cancer Research Technology
US Patent
Cancer Research Technology
US Patent
Affinity DataIC50: 45.6nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair