BDBM488392 2-[4-Amino-1-(1-methylsulfonyl-4- piperidyl)pyrazolo[3,4-d]pyrimidin-3-yl]-3-chloro- N-methyl-1H-indole-6-carboxamide::US10954241, Example 32::US11548896, Example 32

SMILES CNC(=O)c1ccc2c(Cl)c([nH]c2c1)-c1nn(C2CCN(CC2)S(C)(=O)=O)c2ncnc(N)c12

InChI Key InChIKey=HDRICYBPUIHGFB-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 488392   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM488392(2-[4-Amino-1-(1-methylsulfonyl-4- piperidyl)pyrazo...)
Affinity DataIC50:  7.93nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM488392(2-[4-Amino-1-(1-methylsulfonyl-4- piperidyl)pyrazo...)
Affinity DataIC50:  4.58E+3nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM488392(2-[4-Amino-1-(1-methylsulfonyl-4- piperidyl)pyrazo...)
Affinity DataIC50:  45.6nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM488392(2-[4-Amino-1-(1-methylsulfonyl-4- piperidyl)pyrazo...)
Affinity DataIC50:  7.93nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM488392(2-[4-Amino-1-(1-methylsulfonyl-4- piperidyl)pyrazo...)
Affinity DataIC50:  4.58E+3nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM488392(2-[4-Amino-1-(1-methylsulfonyl-4- piperidyl)pyrazo...)
Affinity DataIC50:  45.6nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent