BDBM567744 US11420968, Example F106

SMILES C[C@]1(O)CC[C@H](CNc2ccc(cc2[N+]([O-])=O)S(=O)(=O)NC(=O)c2ccc(cc2Oc2cnc3[nH]ccc3c2)N2CC3(CC(C3)N3CCC[C@H]3c3ccccc3C3CC3)C2)CC1

InChI Key

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 567744   

TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM567744(US11420968, Example F106)
Affinity DataIC50:  0.0210nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2/Bcl-X protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM567744(US11420968, Example F106)
Affinity DataIC50:  0.0210nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2/Bcl-X protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM567744(US11420968, Example F106)
Affinity DataIC50:  0.720nMAssay Description:Selected compounds disclosed herein were tested for blocking of Bcl-2-G101 protein with its ligand in an assay based on time-resolved fluorescence re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent