BDBM50051293 (S)-(-)-N-(R-ethylbenzyl)-3-hydroxy-2-phenylquinoline-4-carboxamide::3-Hydroxy-2-phenyl-quinoline-4-carboxylic acid ((S)-1-phenyl-propyl)-amide::3-Hydroxy-2-phenyl-quinoline-4-carboxylic acid (1-phenyl-propyl)-amide::CHEMBL10188::SB 223412::SB-2234::SB-223412::Talnetant

SMILES CC[C@H](NC(=O)c1c(O)c(nc2ccccc12)-c1ccccc1)c1ccccc1

InChI Key InChIKey=BIAVGWDGIJKWRM-FQEVSTJZSA-N

Data  28 KI  10 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50051293   

TargetSubstance-K receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051293((S)-(-)-N-(R-ethylbenzyl)-3-hydroxy-2-phenylquinol...)
Affinity DataKi:  144nMAssay Description:Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051293((S)-(-)-N-(R-ethylbenzyl)-3-hydroxy-2-phenylquinol...)
Affinity DataKi:  144nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSubstance-K receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051293((S)-(-)-N-(R-ethylbenzyl)-3-hydroxy-2-phenylquinol...)
Affinity DataKi:  144nMAssay Description:Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051293((S)-(-)-N-(R-ethylbenzyl)-3-hydroxy-2-phenylquinol...)
Affinity DataKi:  3.70E+3nMAssay Description:Binding affinity to human NK2 receptor by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051293((S)-(-)-N-(R-ethylbenzyl)-3-hydroxy-2-phenylquinol...)
Affinity DataKi:  3.98E+3nMAssay Description:Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051293((S)-(-)-N-(R-ethylbenzyl)-3-hydroxy-2-phenylquinol...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed