BDBM50507645 CHEMBL4473820
SMILES CN1CCC(CC1)Nc1ccc(cc1)C(=O)Nc1cc(n[nH]1)-c1cc(cs1)C#N
InChI Key InChIKey=HGLWPJISHDLCTE-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 20 hits for monomerid = 50507645
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataKd: 87nMAssay Description:Binding affinity to human partial length FLT3 ITD/F691L double mutant expressed in bacterial expression system after 60 mins by Kinomescan methodMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataKd: 300nMAssay Description:Binding affinity to human phosphorylated ABL1 Q252H mutant expressed in mammalian expression system after 60 mins by Kinomescan methodMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataKd: 6.90E+3nMAssay Description:Binding affinity to human non-phosphorylated ABL1 F317L mutant (S229 to K512 residues) expressed in mammalian expression system after 60 mins by Kino...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataKd: 460nMAssay Description:Binding affinity to human phosphorylated ABL1 F317L mutant (S229 to K512 residues) expressed in mammalian expression system after 60 mins by Kinomesc...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataKd: 280nMAssay Description:Binding affinity to human non-phosphorylated ABL1 H396P mutant (S229 to K512 residues) expressed in mammalian expression system after 60 mins by Kino...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataKd: 350nMAssay Description:Binding affinity to human non-phosphorylated ABL1 Q252H mutant (S229 to K512 residues) expressed in mammalian expression system after 60 mins by Kino...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataKd: 500nMAssay Description:Binding affinity to human phosphorylated ABL1 T315I mutant (S229 to K512 residues) expressed in mammalian expression system after 60 mins by Kinomesc...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataKd: 520nMAssay Description:Binding affinity to wild-type human phosphorylated ABL1 (S229 to K512 residues) expressed in mammalian expression system after 60 mins by Kinomescan ...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataKd: 84nMAssay Description:Binding affinity to wild-type human partial length autoinhibited CSF1R (Y538 to S939 residues) expressed in mammalian expression system after 60 mins...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataKd: 5.60nMAssay Description:Binding affinity to wild-type human partial length autoinhibited FLT3 (H564 to Y969 residues) expressed in mammalian expression system after 60 mins ...More data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataKd: 72nMAssay Description:Binding affinity to wild-type human partial length autoinhibited KIT (Y545 to D952 residues) expressed in mammalian expression system after 60 mins b...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataKd: 53nMAssay Description:Binding affinity to human partial length FLT3 ITD/D835V double mutant expressed in bacterial expression system after 60 mins by Kinomescan methodMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to human phosphorylated ABL1 F317I mutant (S229 to K512 residues) expressed in mammalian expression system after 60 mins by Kinomesc...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataKd: 390nMAssay Description:Binding affinity to human phosphorylated ABL1 H396P mutant (S229 to K512 residues) expressed in mammalian expression system after 60 mins by Kinomesc...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataKd: 370nMAssay Description:Binding affinity to wild-type human non-phosphorylated ABL1 (S229 to K512 residues) expressed in mammalian expression system after 60 mins by Kinomes...More data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataKd: 2.20nMAssay Description:Binding affinity to wild-type human partial length KIT (I571 to D952 residues) expressed in bacterial expression system after 60 mins by Kinomescan m...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to human non-phosphorylated ABL1 F317I mutant (S229 to K512 residues) expressed in mammalian expression system after 60 mins by Kino...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataKd: 47nMAssay Description:Binding affinity to wild-type human partial length CSF1R (I564 to S939 residues) expressed in bacterial expression system after 60 mins by Kinomescan...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataKd: 580nMAssay Description:Binding affinity to human non-phosphorylated ABL1 T315I mutant (S229 to K512 residues) expressed in mammalian expression system after 60 mins by Kino...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataKd: 2.80nMAssay Description:Binding affinity to wild-type human partial length FLT3 (H564 to Y969 residues) expressed in mammalian expression system after 60 mins by Kinomescan ...More data for this Ligand-Target Pair