BDBM50360601 CHEMBL1933349::MK-0893

SMILES COc1ccc2cc(ccc2c1)-c1cc(nn1[C@@H](C)c1ccc(cc1)C(=O)NCCC(O)=O)-c1cc(Cl)cc(Cl)c1

InChI Key InChIKey=DNTVJEMGHBIUMW-IBGZPJMESA-N

Data  1 KI  22 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50360601   

TargetGlucagon receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50360601(CHEMBL1933349 | MK-0893)
Affinity DataKi:  70nMAssay Description:Displacement of [125I]Glucagon-Cex from human GCGRMore data for this Ligand-Target Pair
TargetGlucagon receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50360601(CHEMBL1933349 | MK-0893)
Affinity DataIC50:  6.60nMAssay Description:Displacement of [125I]glucagon from human GCGR expressed in CHO cells after 3 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
TargetGlucagon receptor [1-477](Macaca mulatta)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50360601(CHEMBL1933349 | MK-0893)
Affinity DataIC50:  56nMAssay Description:Antagonist activity at rhesus monkey GCGR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 min...More data for this Ligand-Target Pair
TargetUncharacterized protein [173-650](Canis familiaris)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50360601(CHEMBL1933349 | MK-0893)
Affinity DataIC50:  105nMAssay Description:Antagonist activity at dog GCGR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior to...More data for this Ligand-Target Pair
TargetGlucagon receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50360601(CHEMBL1933349 | MK-0893)
Affinity DataIC50:  80nMAssay Description:Antagonist activity at human glucagon receptor expressed in HEK293T cells assessed as inhibition of glucagon-induced cAMP accumulation after 30 mins ...More data for this Ligand-Target Pair
TargetGlucagon receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50360601(CHEMBL1933349 | MK-0893)
Affinity DataIC50:  20nMAssay Description:Displacement of [125I]-glucagon from wild type human glucagon receptor expressed in CHOK1 cells after 3 hrs by micro beta scintillation counting anal...More data for this Ligand-Target Pair
TargetGlucagon receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50360601(CHEMBL1933349 | MK-0893)
Affinity DataIC50:  16nMAssay Description:Antagonist activity at human GCGR expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior ...More data for this Ligand-Target Pair