BDBM50242733 AT-13148

SMILES NC[C@@](O)(c1ccc(Cl)cc1)c1ccc(cc1)-c1cn[nH]c1

InChI Key InChIKey=IIRWNGPLJQXWFJ-UHFFFAOYSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50242733   

TargetRho-associated protein kinase 1(Human)
Amakem Therapeutics

Curated by ChEMBL
LigandPNGBDBM50242733(AT-13148)
Affinity DataIC50: 10nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
LigandPNGBDBM50242733(AT-13148)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human His-tagged PKA catalytic domain (1 to 351 residues) expressed in Escherichia coli using Ser/Thr 7 as substrate after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2019
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Amakem Therapeutics

Curated by ChEMBL
LigandPNGBDBM50242733(AT-13148)
Affinity DataIC50: 10nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetcAMP-dependent protein kinase catalytic subunit gamma(Human)
Amakem Therapeutics

Curated by ChEMBL
LigandPNGBDBM50242733(AT-13148)
Affinity DataIC50: 10nMAssay Description:Inhibition of PKA (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50242733(AT-13148)
Affinity DataIC50: 38nMAssay Description:Inhibition of PKBalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50242733(AT-13148)
Affinity DataIC50: 38nMAssay Description:Inhibition of recombinant full length human His-tagged AKT1 expressed in baculovirus expression system using ser/thr 6 as substrate after 1 hr by FRE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2019
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50242733(AT-13148)
Affinity DataIC50: 38nMAssay Description:Inhibition of AKT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
LigandPNGBDBM50242733(AT-13148)
Affinity DataIC50: 50nMAssay Description:Inhibition of recombinant human full length His-tagged AKT3 expressed in baculovirus expression system using ser/thr 6 as substrate after 1 hr by FRE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2019
Entry Details Article
PubMed
LigandPNGBDBM50242733(AT-13148)
Affinity DataIC50: 50nMAssay Description:Inhibition of AKT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase Sgk3(Human)
Amakem Therapeutics

Curated by ChEMBL
LigandPNGBDBM50242733(AT-13148)
Affinity DataIC50: 50nMAssay Description:Inhibition of SGK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
LigandPNGBDBM50242733(AT-13148)
Affinity DataIC50: 50nMAssay Description:Inhibition of PKBgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetRibosomal protein S6 kinase alpha-1(Human)
Amakem Therapeutics

Curated by ChEMBL
LigandPNGBDBM50242733(AT-13148)
Affinity DataIC50: 85nMAssay Description:Inhibition of RSK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
LigandPNGBDBM50242733(AT-13148)
Affinity DataIC50: 402nMAssay Description:Inhibition of recombinant human full length His-tagged AKT2 expressed in baculovirus expression system using ser/thr 6 as substrate after 1 hr by FRE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2019
Entry Details Article
PubMed
LigandPNGBDBM50242733(AT-13148)
Affinity DataIC50: 402nMAssay Description:Inhibition of PKBbeta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50242733(AT-13148)
Affinity DataIC50: 402nMAssay Description:Inhibition of AKT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed