BDBM50632668 BAY-294

SMILES CNCc1ccccc1-c1csc(c1)[C@H](C)Nc1nc(C)nc2cc(OC)c(OC)cc12

InChI Key InChIKey=WEGLOYDTDILXDA-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50632668   

TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50632668(BAY-294)
Affinity DataIC50: 1.89E+3nMAssay Description:Inhibition of N-terminal His10-tagged wild-type recombinant human SOS1 catalytic domain (564 to 1049 residues) expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632668(BAY-294)
Affinity DataIC50: 2.34E+3nMAssay Description:Inhibition of human recombinant SOS1/KRAS G12D mutant protein-protein interaction expressed in Escherichia coli BL21 (DE3) cells incubated for 3 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632668(BAY-294)
Affinity DataIC50: 2.34E+3nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human KRAS G12C mutant (1 to 169 residues) expressed in Escherichia coli/N-terminal His10-tagged wild...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632668(BAY-294)
Affinity DataIC50: 2.34E+3nMAssay Description:Inhibition of SOS1/KRAS (unknown origin) protein-protein interactionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50632668(BAY-294)
Affinity DataIC50: 2.34E+3nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human KRAS G12C mutant (1 to 169 residues) expressed in Escherichia coli/N-terminal His10-tagged wild...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50632668(BAY-294)
Affinity DataIC50: 3.91E+3nMAssay Description:Inhibition of N-terminal His10-tagged wild-type recombinant human SOS1 catalytic domain (564 to 1049 residues) expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50632668(BAY-294)
Affinity DataIC50: 4.04E+3nMAssay Description:Inhibition of N-terminal His10-tagged wild-type recombinant human SOS1 catalytic domain (564 to 1049 residues) expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50632668(BAY-294)
Affinity DataIC50: 4.12E+3nMAssay Description:Inhibition of SOS1 in human Calu-1 cells assessed as reduction in RAS activation pretreated for 30 mins followed by EGF stimulation for 3 mins by G-L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50632668(BAY-294)
Affinity DataIC50: 4.57E+3nMAssay Description:Inhibition of SOS1 in human K562 cells assessed as reduction in pERK level incubated for 60 mins by HTRF analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50632668(BAY-294)
Affinity DataIC50: 1.86E+4nMAssay Description:Inhibition of SOS1 in human HeLa cells assessed as reduction in RAS activation pretreated for 30 mins followed by EGF stimulation for 3 mins by G-LIS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetGTPase KRas(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50632668(BAY-294)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human KRAS G12C mutant (1 to 169 residues) expressed in Escherichia coli assessed as reduction in int...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetGuanine nucleotide exchange factor DBS(Homo sapiens)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50632668(BAY-294)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human DBS assessed as reduction in CDC42 activation preincubated for 1 min with CDC42 followed by DBS addition measured after 20 mins i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 2(Homo sapiens)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50632668(BAY-294)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of N-terminal His10-tagged wild-type recombinant human SOS2 catalytic domain (564 to 1043 residues) expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50632668(BAY-294)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human EGFR using biotin-aminohexyl-AEEEEYFELVAKKK as substrate preincubated for 15 mins followed by substrate/ATP addition measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Bayer AG

Curated by ChEMBL
LigandPNGBDBM50632668(BAY-294)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of SOS1 in human Calu-1 cells assessed as reduction in pERK level incubated for 24 hrs by HTRF analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed