BDBM14365 8-(1-Benzyloxy-1-methyl-ethyl)-3-(3-cyclopentyloxy-4-methoxy-benzyl)-3H-purin-6-ylamine Hydrochloride::8-[2-(benzyloxy)propan-2-yl]-3-{[3-(cyclopentyloxy)-4-methoxyphenyl]methyl}-3H-purin-6-amine hydrochloride::V11294 Analogue 5a

SMILES COc1ccc(Cn2cnc(N)c3nc(nc23)C(C)(C)OCc2ccccc2)cc1OC1CCCC1

InChI Key InChIKey=SCAQJDLHHQAAFF-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 14365   

LigandPNGBDBM14365(8-(1-Benzyloxy-1-methyl-ethyl)-3-(3-cyclopentyloxy...)
Affinity DataKi:  4.10nMAssay Description:PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM14365(8-(1-Benzyloxy-1-methyl-ethyl)-3-(3-cyclopentyloxy...)
Affinity DataKi:  5.70nMAssay Description:PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM14365(8-(1-Benzyloxy-1-methyl-ethyl)-3-(3-cyclopentyloxy...)
Affinity DataKi:  8.90nMAssay Description:PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM14365(8-(1-Benzyloxy-1-methyl-ethyl)-3-(3-cyclopentyloxy...)
Affinity DataKi:  179nM ΔG°:  -9.11kcal/molepH: 8.0 T: 22°CAssay Description:PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM14365(8-(1-Benzyloxy-1-methyl-ethyl)-3-(3-cyclopentyloxy...)
Affinity DataKi:  413nMAssay Description:PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed