BDBM150811 US8981106, 1 (SX-517)::USRE47267, Compound 1
SMILES OB(O)c1ccccc1CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1
InChI Key InChIKey=VZRIHFZJVIOJBE-UHFFFAOYSA-N
Data 14 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 14 hits for monomerid = 150811
Affinity DataIC50: 38nMT: 37°CAssay Description:An in vitro assay showed inhibition of CXCR2-mediated intracellular calcium release. Briefly, human neutrophils were suspended in HBSS- (without Ca2+...More data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...More data for this Ligand-Target Pair
Affinity DataIC50: 210nMAssay Description:Antagonist activity at human CXCR2 expressed in HEK293 cells assessed as inhibition of CXCL8-induced intracellular Ca2+ release by fluorescence based...More data for this Ligand-Target Pair
Affinity DataIC50: 880nMAssay Description:Antagonist activity at human CXCR1 expressed in HEK293 cells assessed as inhibition of CXCL8-induced intracellular Ca2+ release by fluorescence based...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+3nMAssay Description:Antagonist activity at fMLF receptor in human PMNs assessed as inhibition of fMLF-induced intracellular Ca2+ release by fluorescence based calcium fl...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+3nMAssay Description:Antagonist activity at platelet-activating factor receptor in human PMNs assessed as inhibition of PAF-induced intracellular Ca2+ release by fluoresc...More data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...More data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Antagonist activity at human CXCR2 expressed in HEK293 cells assessed as inhibition of CVCL8-induced [35S]GTPgammaS binding after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 730nMAssay Description:Inhibition of CXCR2 (unknown origin) expressed in PathHunter celline by beta-arrestin assayMore data for this Ligand-Target Pair
Affinity DataIC50: 356nMAssay Description:Inhibition of CXCR2 (unknown origin) transfected with RBL cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 903nMAssay Description:Inhibition of CXCR1 (unknown origin) transfected with RBL cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...More data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+3nMAssay Description:Antagonist activity at C5a receptor in human PMNs assessed as inhibition of C5a-induced intracellular Ca2+ release by fluorescence based calcium flux...More data for this Ligand-Target Pair