BDBM17335 1-[(2R)-2-{[(4-cyanophenyl)methyl](methyl)amino}-3-(1-methyl-1H-imidazol-5-yl)propanoyl]-5-(naphthalen-1-yl)-1,2,3,6-tetrahydropyridine-4-carbonitrile::CHEMBL29980::histidine derivative, 37

SMILES CN(Cc1ccc(cc1)C#N)[C@H](Cc1cncn1C)C(=O)N1CCC(C#N)=C(C1)c1cccc2ccccc12

InChI Key InChIKey=JHFMJRWJSSLDJT-UHFFFAOYSA-N

Data  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 17335   

LigandPNGBDBM17335(1-[(2R)-2-{[(4-cyanophenyl)methyl](methyl)amino}-3...)
Affinity DataIC50: 0.920nMAssay Description:In vitro inhibition of farnesyltransferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM17335(1-[(2R)-2-{[(4-cyanophenyl)methyl](methyl)amino}-3...)
Affinity DataIC50: 0.920nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2007
Entry Details Article
PubMed
LigandPNGBDBM17335(1-[(2R)-2-{[(4-cyanophenyl)methyl](methyl)amino}-3...)
Affinity DataEC50: >100nMAssay Description:Inhibition of Ras farnesylation in Human Ha-Ras oncogene-transformed BALB/c 3T3 cells (EJ3 cells)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM17335(1-[(2R)-2-{[(4-cyanophenyl)methyl](methyl)amino}-3...)
Affinity DataIC50: 1.60E+3nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting GGTase-1 was determined by measuring the transfer of [3H]-geranylgeranylpyrophosphate to substrate Ha-R...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2007
Entry Details Article
PubMed
LigandPNGBDBM17335(1-[(2R)-2-{[(4-cyanophenyl)methyl](methyl)amino}-3...)
Affinity DataIC50: 1.60E+3nMAssay Description:In vitro inhibition of geranylgeranyltransferase-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed