BDBM195556 (2E)-2-(Pyridin-3-ylmethylidene)-2,3-dihydro-1H-inden-1-one (11a)

SMILES O=C1\C(Cc2ccccc12)=C\c1cccnc1

InChI Key InChIKey=UCAONOPVOXJPQZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 195556   

TargetAmine oxidase [flavin-containing] A(Human)
North-West University

LigandPNGBDBM195556((2E)-2-(Pyridin-3-ylmethylidene)-2,3-dihydro-1H-in...)
Affinity DataIC50: 61nMpH: 7.4Assay Description:Recombinant human MAO-A and MAO-B were used for these studies and kynuramine served as enzyme substrate. Kynuramine is oxidised by both MAO isoforms ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM195556((2E)-2-(Pyridin-3-ylmethylidene)-2,3-dihydro-1H-in...)
Affinity DataIC50: 500nMAssay Description:Inhibition of human MAO-B using kynuramine as substrate incubated for 20 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM195556((2E)-2-(Pyridin-3-ylmethylidene)-2,3-dihydro-1H-in...)
Affinity DataIC50: 1.27E+3nMpH: 7.4Assay Description:Recombinant human MAO-A and MAO-B were used for these studies and kynuramine served as enzyme substrate. Kynuramine is oxidised by both MAO isoforms ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed