BDBM195557 (2E)-5-Methoxy-2-(pyridin-3-ylmethylidene)-2,3-dihydro-1Hinden-1-one (11b)

SMILES COc1ccc2C(=O)\C(Cc2c1)=C\c1cccnc1

InChI Key InChIKey=UOMGEIJNVUHHAL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 195557   

TargetAmine oxidase [flavin-containing] B(Human)
North-West University

LigandPNGBDBM195557((2E)-5-Methoxy-2-(pyridin-3-ylmethylidene)-2,3-dih...)
Affinity DataIC50: 338nMpH: 7.4Assay Description:Recombinant human MAO-A and MAO-B were used for these studies and kynuramine served as enzyme substrate. Kynuramine is oxidised by both MAO isoforms ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
North-West University

LigandPNGBDBM195557((2E)-5-Methoxy-2-(pyridin-3-ylmethylidene)-2,3-dih...)
Affinity DataIC50: 500nMAssay Description:Inhibition of human MAO-B using kynuramine as substrate incubated for 20 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
North-West University

LigandPNGBDBM195557((2E)-5-Methoxy-2-(pyridin-3-ylmethylidene)-2,3-dih...)
Affinity DataIC50: 8.55E+3nMpH: 7.4Assay Description:Recombinant human MAO-A and MAO-B were used for these studies and kynuramine served as enzyme substrate. Kynuramine is oxidised by both MAO isoforms ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed