BDBM195569 (2E)-2-[(5-Bromofuran-2-yl)methylidene]-5-methoxy-2,3-dihydro-1H-inden-1-one (11o)

SMILES COc1ccc2C(=O)\C(Cc2c1)=C\c1ccc(Br)o1

InChI Key InChIKey=UJKXUNOFSDTDGU-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 195569   

TargetAmine oxidase [flavin-containing] B(Human)
North-West University

LigandPNGBDBM195569((2E)-2-[(5-Bromofuran-2-yl)methylidene]-5-methoxy-...)
Affinity DataIC50: 4.40nMpH: 7.4Assay Description:Recombinant human MAO-A and MAO-B were used for these studies and kynuramine served as enzyme substrate. Kynuramine is oxidised by both MAO isoforms ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
North-West University

LigandPNGBDBM195569((2E)-2-[(5-Bromofuran-2-yl)methylidene]-5-methoxy-...)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of human MAO-B using kynuramine as substrate incubated for 20 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
North-West University

LigandPNGBDBM195569((2E)-2-[(5-Bromofuran-2-yl)methylidene]-5-methoxy-...)
Affinity DataIC50: 40nMAssay Description:Inhibition of recombinant human MAO-B assessed as inhibition of 4-hydroxyquinoline formation using kynuramine as substrate incubated for 20 mins by f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM195569((2E)-2-[(5-Bromofuran-2-yl)methylidene]-5-methoxy-...)
Affinity DataIC50: 180nMAssay Description:Inhibition of recombinant human MAO-A assessed as inhibition of 4-hydroxyquinoline formation using kynuramine as substrate incubated for 20 mins by f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Universite Grenoble Alpes

Curated by ChEMBL
LigandPNGBDBM195569((2E)-2-[(5-Bromofuran-2-yl)methylidene]-5-methoxy-...)
Affinity DataIC50: 183nMpH: 7.4Assay Description:Recombinant human MAO-A and MAO-B were used for these studies and kynuramine served as enzyme substrate. Kynuramine is oxidised by both MAO isoforms ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2016
Entry Details Article
PubMed