BDBM258112 US9493448, 14::US9493448, 31::US9597330, Example 7::US9845313, Example 31

SMILES Cn1nccc1[C@H]1CCC[C@@H]1Oc1cc(F)c(cc1F)S(=O)(=O)Nc1ccncn1

InChI Key InChIKey=GHOSFOBBUGQTRM-WBMJQRKESA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 258112   

TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Daiichi Sankyo

US Patent
LigandPNGBDBM258112(US9493448, 14 | US9493448, 31 | US9597330, Example...)
Affinity DataIC50:  150nMpH: 7.3 T: 2°CAssay Description:Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Daiichi Sankyo

US Patent
LigandPNGBDBM258112(US9493448, 14 | US9493448, 31 | US9597330, Example...)
Affinity DataIC50:  58nMpH: 7.3 T: 2°CAssay Description:Current record was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. The o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Daiichi Sankyo

US Patent
LigandPNGBDBM258112(US9493448, 14 | US9493448, 31 | US9597330, Example...)
Affinity DataIC50:  150nMAssay Description:Current recording was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Daiichi Sankyo

US Patent
LigandPNGBDBM258112(US9493448, 14 | US9493448, 31 | US9597330, Example...)
Affinity DataIC50:  58nMAssay Description:Current recording was obtained by an automated patch clamp system IonWorks Quattro (Molecular Devices Corporation) in Population Patch Clamp mode. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Daiichi Sankyo

US Patent
LigandPNGBDBM258112(US9493448, 14 | US9493448, 31 | US9597330, Example...)
Affinity DataIC50:  150nMAssay Description:Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM258112(US9493448, 14 | US9493448, 31 | US9597330, Example...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human ERG by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 1 subunit alpha/subunit beta-1/subunit beta-2(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM258112(US9493448, 14 | US9493448, 31 | US9597330, Example...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human NaV1.1/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha/subunit beta-1/subunit beta-2(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM258112(US9493448, 14 | US9493448, 31 | US9597330, Example...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human NaV1.5/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel subunit beta-2(Homo sapiens)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM258112(US9493448, 14 | US9493448, 31 | US9597330, Example...)
Affinity DataIC50:  180nMAssay Description:Inhibition of human NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel subunit beta-2(Mus musculus)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM258112(US9493448, 14 | US9493448, 31 | US9597330, Example...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of mouse NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Daiichi Sankyo

US Patent
LigandPNGBDBM258112(US9493448, 14 | US9493448, 31 | US9597330, Example...)
Affinity DataIC50:  58nMAssay Description:Current record was obtained by an automated patch clamp system “IonWorks Quattro (Molecular Devices Corporation)” in Population Patch Clamp mode. The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent