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Found 88 Enz. Inhib. hit(s) with Target = 'Sodium channel subunit beta-2'
TargetSodium channel subunit beta-2(Homo sapiens)TBA
LigandPNGBDBM145285(US8952169, 64 | US9771376, Example 64)
Affinity DataIC50:  0.400nMMore data for this Ligand-Target Pair
In DepthDetails
TargetSodium channel subunit beta-2(Homo sapiens)TBA
LigandPNGBDBM70937(US9546164, 100 | US9694002, 100)
Affinity DataIC50:  0.600nMMore data for this Ligand-Target Pair
In DepthDetails
TargetSodium channel subunit beta-2(Homo sapiens)TBA
LigandPNGBDBM50257179(CHEMBL2325622)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel subunit beta-2(Mus musculus)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50240267(CHEMBL2325014)
Affinity DataIC50:  4.90nMAssay Description:Inhibition of mouse NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
TargetSodium channel subunit beta-2(Homo sapiens)TBA
LigandPNGBDBM258102(US9493448, 4 | US9845313, Example 4)
Affinity DataIC50:  12nMAssay Description:Inhibition of human NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel subunit beta-2(Homo sapiens)TBA
LigandPNGBDBM50240267(CHEMBL2325014)
Affinity DataIC50:  13nMAssay Description:Inhibition of human NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
TargetSodium channel subunit beta-2(Homo sapiens)TBA
LigandPNGBDBM50613335(CHEMBL5288162)
Affinity DataIC50:  14nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetSodium channel subunit beta-2(Mus musculus)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM258162(US9493448, 64 | US9597330, Example 21 | US9845313,...)
Affinity DataIC50:  15nMAssay Description:Inhibition of mouse NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel subunit beta-2(Homo sapiens)TBA
LigandPNGBDBM50613342(CHEMBL5286433)
Affinity DataIC50:  15nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetSodium channel subunit beta-2(Mus musculus)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50613344(CHEMBL5284082)
Affinity DataIC50:  15nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetSodium channel subunit beta-2(Mus musculus)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50613336(CHEMBL5276801)
Affinity DataIC50:  16nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetSodium channel subunit beta-2(Homo sapiens)TBA
LigandPNGBDBM258106(US9493448, 8 | US9845313, Example 8)
Affinity DataIC50:  17nMAssay Description:Inhibition of human NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel subunit beta-2(Mus musculus)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM258102(US9493448, 4 | US9845313, Example 4)
Affinity DataIC50:  17nMAssay Description:Inhibition of mouse NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel subunit beta-2(Homo sapiens)TBA
LigandPNGBDBM50613336(CHEMBL5276801)
Affinity DataIC50:  19nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetSodium channel subunit beta-2(Homo sapiens)TBA
LigandPNGBDBM258141(US9493448, 43 | US9597330, Example 10 | US9845313,...)
Affinity DataIC50:  24nMAssay Description:Inhibition of human NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel subunit beta-2(Homo sapiens)TBA
LigandPNGBDBM258146(US9493448, 122 | US9493448, 154 | US9493448, 48 | ...)
Affinity DataIC50:  24.5nMAssay Description:Inhibition of human NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel subunit beta-2(Homo sapiens)TBA
LigandPNGBDBM258146(US9493448, 122 | US9493448, 154 | US9493448, 48 | ...)
Affinity DataIC50:  25nMAssay Description:Inhibition of human NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel subunit beta-2(Mus musculus)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM258146(US9493448, 122 | US9493448, 154 | US9493448, 48 | ...)
Affinity DataIC50:  26.5nMAssay Description:Inhibition of mouse NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel subunit beta-2(Mus musculus)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM258146(US9493448, 122 | US9493448, 154 | US9493448, 48 | ...)
Affinity DataIC50:  27nMAssay Description:Inhibition of mouse NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel subunit beta-2(Homo sapiens)TBA
LigandPNGBDBM301817(5-Chloro-2-fluoro-4-{[(1S*,2R*)-2-(1-methyl-1H-pyr...)
Affinity DataIC50:  28nMAssay Description:Inhibition of human NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel subunit beta-2(Homo sapiens)TBA
LigandPNGBDBM258113(US9493448, 15 | US9845313, Example 15)
Affinity DataIC50:  28nMAssay Description:Inhibition of human NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel subunit beta-2(Mus musculus)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM258141(US9493448, 43 | US9597330, Example 10 | US9845313,...)
Affinity DataIC50:  28nMAssay Description:Inhibition of mouse NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel subunit beta-2(Mus musculus)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM258118(US9493448, 20 | US9597330, Example 2 | US9845313, ...)
Affinity DataIC50:  28nMAssay Description:Inhibition of mouse NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel subunit beta-2(Homo sapiens)TBA
LigandPNGBDBM258144(US9493448, 46 | US9597330, Example 11 | US9845313,...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel subunit beta-2(Homo sapiens)TBA
LigandPNGBDBM258162(US9493448, 64 | US9597330, Example 21 | US9845313,...)
Affinity DataIC50:  31nMAssay Description:Inhibition of human NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel subunit beta-2(Homo sapiens)TBA
LigandPNGBDBM50613337(CHEMBL5286829)
Affinity DataIC50:  32nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetSodium channel subunit beta-2(Homo sapiens)TBA
LigandPNGBDBM50613334(CHEMBL5270366)
Affinity DataIC50:  34nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetSodium channel subunit beta-2(Homo sapiens)TBA
LigandPNGBDBM50613328(CHEMBL5280425)
Affinity DataIC50:  38nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetSodium channel subunit beta-2(Homo sapiens)TBA
LigandPNGBDBM50613344(CHEMBL5284082)
Affinity DataIC50:  40nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetSodium channel subunit beta-2(Mus musculus)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM301817(5-Chloro-2-fluoro-4-{[(1S*,2R*)-2-(1-methyl-1H-pyr...)
Affinity DataIC50:  41nMAssay Description:Inhibition of mouse NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel subunit beta-2(Homo sapiens)TBA
LigandPNGBDBM258118(US9493448, 20 | US9597330, Example 2 | US9845313, ...)
Affinity DataIC50:  45nMAssay Description:Inhibition of human NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel subunit beta-2(Homo sapiens)TBA
LigandPNGBDBM50405441(CHEMBL5286125)
Affinity DataIC50:  52nMMore data for this Ligand-Target Pair
In DepthDetails
TargetSodium channel subunit beta-2(Mus musculus)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM258144(US9493448, 46 | US9597330, Example 11 | US9845313,...)
Affinity DataIC50:  56nMAssay Description:Inhibition of mouse NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel subunit beta-2(Homo sapiens)TBA
LigandPNGBDBM50613332(CHEMBL5285313)
Affinity DataIC50:  58nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetSodium channel subunit beta-2(Mus musculus)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM258146(US9493448, 122 | US9493448, 154 | US9493448, 48 | ...)
Affinity DataIC50:  59nMAssay Description:Inhibition of mouse Nav1.7/beta1/beta2 expressed in HEK293A cells with -120 mV holding potential by whole cell manual patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel subunit beta-2(Homo sapiens)TBA
LigandPNGBDBM50613343(CHEMBL5287784)
Affinity DataIC50:  59nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetSodium channel subunit beta-2(Homo sapiens)TBA
LigandPNGBDBM258125(US9493448, 27 | US9597330, Example 4 | US9845313, ...)
Affinity DataIC50:  60nMAssay Description:Inhibition of human NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel subunit beta-2(Mus musculus)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50613342(CHEMBL5286433)
Affinity DataIC50:  61nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetSodium channel subunit beta-2(Homo sapiens)TBA
LigandPNGBDBM50613341(CHEMBL5267728)
Affinity DataIC50:  85nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetSodium channel subunit beta-2(Homo sapiens)TBA
LigandPNGBDBM50613330(CHEMBL5269981)
Affinity DataIC50:  87nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetSodium channel subunit beta-2(Mus musculus)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM258125(US9493448, 27 | US9597330, Example 4 | US9845313, ...)
Affinity DataIC50:  96nMAssay Description:Inhibition of mouse NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel subunit beta-2(Mus musculus)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM258113(US9493448, 15 | US9845313, Example 15)
Affinity DataIC50:  100nMAssay Description:Inhibition of mouse NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel subunit beta-2(Homo sapiens)TBA
LigandPNGBDBM258123(US9493448, 25 | US9597330, Example 3 | US9845313, ...)
Affinity DataIC50:  113nMAssay Description:Inhibition of human NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel subunit beta-2(Homo sapiens)TBA
LigandPNGBDBM258112(US9493448, 14 | US9493448, 31 | US9597330, Example...)
Affinity DataIC50:  180nMAssay Description:Inhibition of human NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel subunit beta-2(Homo sapiens)TBA
LigandPNGBDBM50613333(CHEMBL5276666)
Affinity DataIC50:  190nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetSodium channel subunit beta-2(Homo sapiens)TBA
LigandPNGBDBM50613329(CHEMBL5270710)
Affinity DataIC50:  190nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetSodium channel subunit beta-2(Mus musculus)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM258106(US9493448, 8 | US9845313, Example 8)
Affinity DataIC50:  240nMAssay Description:Inhibition of mouse NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel subunit beta-2(Homo sapiens)TBA
LigandPNGBDBM50613331(CHEMBL5283939)
Affinity DataIC50:  260nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
TargetSodium channel subunit beta-2(Homo sapiens)TBA
LigandPNGBDBM258103(US9493448, 10 | US9493448, 5)
Affinity DataIC50:  290nMAssay Description:Inhibition of human NaV1.7/beta1/beta2 expressed in HEK293A cells by Ionworks high-throughput electrophysiology methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel subunit beta-2(Homo sapiens)TBA
LigandPNGBDBM50613325(CHEMBL5273849)
Affinity DataIC50:  330nMMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails
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