BDBM26281 2-{3-[(7-{3-[4-(hydroxymethyl)piperidin-1-yl]propoxy}-6-methoxyquinazolin-4-yl)amino]-1H-pyrazol-5-yl}-N-(3-hydroxyphenyl)acetamide::pyrazoloquinazoline deriv., 15

SMILES COc1cc2c(Nc3cc(CC(=O)Nc4cccc(O)c4)n[nH]3)ncnc2cc1OCCCN1CCC(CO)CC1

InChI Key InChIKey=NYKVYBKVQOVZIQ-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 26281   

TargetAurora kinase B(Human)
Astrazeneca

LigandPNGBDBM26281(2-{3-[(7-{3-[4-(hydroxymethyl)piperidin-1-yl]propo...)
Affinity DataKi:  140nM ΔG°:  -9.25kcal/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2009
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Astrazeneca

LigandPNGBDBM26281(2-{3-[(7-{3-[4-(hydroxymethyl)piperidin-1-yl]propo...)
Affinity DataKi:  4.00E+3nM ΔG°:  -7.36kcal/moleT: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2009
Entry Details Article
PubMed